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EGFR Transactivation by Gastrin
Stable Identifier
R-HSA-2179392
DOI
10.3180/R-HSA-2179392.4
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Gastrin-CREB signalling pathway via PKC and MAPK (Homo sapiens)
EGFR Transactivation by Gastrin (Homo sapiens)
General
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Gastrin, through the action of diacylglycerol produced from downstream G alpha (q) events, transactivates EGFR via a PKC-mediated pathway by activation of MMP3 (Matrix Metalloproteinase 3) which allows formation of mature HBEGF (heparin-binding epidermal growth factor) by cleaving pro-HBEGF. Mature HBEGF is then free to bind the EGFR, resulting in EGFR activation (Dufresne et al. 2006, Liebmann 2011).
Literature References
PubMed ID
Title
Journal
Year
20398727
EGF receptor activation by GPCRs: an universal pathway reveals different versions
Liebmann, C
Mol Cell Endocrinol
2011
16816139
Cholecystokinin and gastrin receptors
Fourmy, D
,
Dufresne, M
,
Seva, C
Physiol Rev
2006
Participants
Events
Diacylgycerol activates Protein kinase C, alpha type
(Homo sapiens)
Activated PKC-alpha activate MMP3
(Homo sapiens)
Active MMP3 can cleave pro-HBEGF to form active HBEGF
(Homo sapiens)
Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor
(Homo sapiens)
GRB2:SOS1 binds to HBEGF:p-Y-EGFR
(Homo sapiens)
SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
(Homo sapiens)
Participates
as an event of
Gastrin-CREB signalling pathway via PKC and MAPK (Homo sapiens)
Orthologous Events
EGFR Transactivation by Gastrin (Bos taurus)
EGFR Transactivation by Gastrin (Caenorhabditis elegans)
EGFR Transactivation by Gastrin (Canis familiaris)
EGFR Transactivation by Gastrin (Danio rerio)
EGFR Transactivation by Gastrin (Dictyostelium discoideum)
EGFR Transactivation by Gastrin (Drosophila melanogaster)
EGFR Transactivation by Gastrin (Gallus gallus)
EGFR Transactivation by Gastrin (Mus musculus)
EGFR Transactivation by Gastrin (Rattus norvegicus)
EGFR Transactivation by Gastrin (Saccharomyces cerevisiae)
EGFR Transactivation by Gastrin (Schizosaccharomyces pombe)
EGFR Transactivation by Gastrin (Sus scrofa)
EGFR Transactivation by Gastrin (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000477
Authored
Tripathi, S (2012-04-04)
Jassal, B (2012-04-04)
Reviewed
D'Eustachio, P (2012-04-23)
Created
Jassal, B (2012-04-04)
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