EGFR Transactivation by Gastrin

Stable Identifier
R-HSA-2179392
DOI
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Gastrin, through the action of diacylglycerol produced from downstream G alpha (q) events, transactivates EGFR via a PKC-mediated pathway by activation of MMP3 (Matrix Metalloproteinase 3) which allows formation of mature HBEGF (heparin-binding epidermal growth factor) by cleaving pro-HBEGF. Mature HBEGF is then free to bind the EGFR, resulting in EGFR activation (Dufresne et al. 2006, Liebmann 2011).
Literature References
PubMed ID Title Journal Year
20398727 EGF receptor activation by GPCRs: an universal pathway reveals different versions

Liebmann, C

Mol Cell Endocrinol 2011
16816139 Cholecystokinin and gastrin receptors

Fourmy, D, Dufresne, M, Seva, C

Physiol Rev 2006
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