SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)

Stable Identifier
R-HSA-2179407
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SOS1 is the guanine nucleotide exchange factor (GEF) for RAS. SOS1 activates RAS nucleotide exchange from the inactive form (bound to GDP) to an active form (bound to GTP) (Chardin et al. 1993).

Literature References
PubMed ID Title Journal Year
8493579 Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

Chardin, P, Camonis, JH, Gale, NW, Van Aelst, L, Schlessinger, J, Wigler, MH, Bar-Sagi, D

Science 1993
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Ras guanyl-nucleotide exchange factor activity of GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created