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MEN1 [nucleoplasm]
Stable Identifier
R-HSA-2186626
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Menin, SCG2
Locations in the PathwayBrowser for interactor UniProt:Q03164%20KMT2A
Expand all
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Formation of WDR5-containing histone-modifying complexes (Homo sapiens)
MEN1 binds MLL1 complex (Homo sapiens)
MEN1 [nucleoplasm] (Homo sapiens)
MEN1 binds MLL2 complex (Homo sapiens)
MEN1 [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
MEN1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)
MEN1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
MEN1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)
MEN1 [nucleoplasm] (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Deactivation of the beta-catenin transactivating complex (Homo sapiens)
APC promotes disassembly of beta-catenin transactivation complex (Homo sapiens)
MEN1 [nucleoplasm] (Homo sapiens)
Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
Recruitment of SET1 methyltransferase complex (Homo sapiens)
MEN1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00255 MEN1
Gene Names
MEN1, SCG2
Chain
chain:1-610
Reference Genes
BioGPS Gene:4221 MEN1
COSMIC (genes):MEN1 MEN1
CTD Gene:4221 MEN1
dbSNP Gene:4221 MEN1
ENSEMBL:ENSG00000133895 MEN1
ENSEMBL_homo_sapiens_GENE:ENSG00000133895.19 MEN1
HGNC:7010 MEN1
Monarch:4221 MEN1
NCBI Gene:4221 MEN1
OMIM:613733 MEN1
UCSC:O00255 MEN1
Reference Transcript
RefSeq:NM_130803.2 MEN1
RefSeq:NM_130802.2 MEN1
RefSeq:NM_130799.2 MEN1
RefSeq:XM_017017769.1 MEN1
RefSeq:NM_000244.3 MEN1
RefSeq:XM_005274001.4 MEN1
RefSeq:NM_130801.2 MEN1
RefSeq:XM_017017770.1 MEN1
RefSeq:NM_130800.2 MEN1
RefSeq:NM_130804.2 MEN1
Other Identifiers
11717609_a_at
16740074
202645_PM_s_at
202645_s_at
3377144
3377145
3377146
3377147
3377148
3377150
3377151
3377152
3377153
3377154
3377155
3377158
3377160
3377161
3377162
3377163
3377164
3377165
3377166
3377167
3377168
3377169
3377170
3377171
3377172
3377173
3377174
4221
448_s_at
7949206
A_23_P75453
A_24_P153898
A_33_P3414058
GE80542
GO:0000122
GO:0000165
GO:0000400
GO:0000403
GO:0000781
GO:0000785
GO:0000976
GO:0001933
GO:0002076
GO:0002376
GO:0003677
GO:0003682
GO:0003690
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005783
GO:0005788
GO:0005829
GO:0005886
GO:0006281
GO:0006325
GO:0006351
GO:0006355
GO:0006357
GO:0006974
GO:0008285
GO:0009411
GO:0010332
GO:0016363
GO:0017053
GO:0023052
GO:0030154
GO:0030511
GO:0030674
GO:0032154
GO:0032991
GO:0035097
GO:0036211
GO:0043226
GO:0043433
GO:0044665
GO:0045064
GO:0045668
GO:0045736
GO:0045786
GO:0045815
GO:0045892
GO:0045944
GO:0046329
GO:0048856
GO:0051219
GO:0051974
GO:0060090
GO:0070412
GO:0071339
HMNXSV003032890
ILMN_1683298
ILMN_1721963
ILMN_2277877
ILMN_2340877
TC11001913.hg
U93237_rna2_at
g4557744_3p_a_at
Participates
as an input of
MEN1 binds MLL1 complex (Homo sapiens)
MEN1 binds MLL2 complex (Homo sapiens)
Recruitment of SET1 methyltransferase complex (Homo sapiens)
MEN1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)
as a component of
MLL1 complex:MEN1 [nucleoplasm] (Homo sapiens)
MLL2 complex:MEN1 [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:SMAD4:MEN1 [nucleoplasm] (Homo sapiens)
as an output of
APC promotes disassembly of beta-catenin transactivation complex (Homo sapiens)
Other forms of this molecule
p-MEN1 [endoplasmic reticulum lumen]
MEN1 [endoplasmic reticulum lumen]
MEN1 [cytosol]
Inferred To
Ghost homologue of MEN1 [nucleoplasm]
(Caenorhabditis elegans)
Ghost homologue of MEN1 [nucleoplasm]
(Gallus gallus)
Men1 [nucleoplasm]
(Mus musculus)
Men1 [nucleoplasm]
(Rattus norvegicus)
Mnn1 [nucleoplasm]
(Drosophila melanogaster)
zgc:110510 [nucleoplasm]
(Danio rerio)
MEN1 [nucleoplasm]
(Bos taurus)
MEN1 [nucleoplasm]
(Canis familiaris)
MEN1 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_570714.1
,
XP_005274058.1
,
XP_016873258.1
,
NP_570715.1
,
NP_570712.1
,
NP_000235.2
,
NP_570713.1
,
NP_570716.1
,
XP_016873259.1
,
NP_570711.1
OpenTargets
ENSG00000133895
ZINC - Substances
MEN1_HUMAN
GeneCards
O00255
HPA
ENSG00000133895-MEN1
ZINC target
O00255
Ensembl
ENSP00000366538
,
ENSP00000308975
,
ENST00000377313
,
ENST00000377326
,
ENSP00000413944
,
ENST00000440873
,
ENST00000450708
,
ENSP00000366543
,
ENSP00000366530
,
ENST00000315422
,
ENSG00000133895
,
ENST00000312049
,
ENST00000377321
,
ENSP00000323747
,
ENSP00000394933
PRO
O00255
Pharos - Targets
O00255
Orphanet
16390
ZINC - Predictions - Purchasable
MEN1_HUMAN
PDB
5DB3
,
5DDE
,
6PKC
,
4OG4
,
5DDD
,
5DB2
,
6O5I
,
3U88
,
4OG3
,
6S2K
,
7O9Z
,
8IG0
,
7UJ4
,
5DD9
,
4OG6
,
6E1A
,
7M4T
,
5DDF
,
4GPQ
,
6BY8
,
6WNH
,
4GQ3
,
6BXY
,
4OG5
,
4X5Y
,
6BXH
,
3U85
,
5DDA
,
4OG8
,
7O9X
,
6B41
,
4GQ6
,
4GQ4
,
4OG7
,
3U84
,
8E90
,
4I80
,
7OA9
,
3U86
,
5DDC
,
5DB1
,
4X5Z
,
7O9T
,
6OPJ
,
5DDB
,
8GPN
,
5DB0
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.708
4
UniProt:Q03164 KMT2A
6
KMT2A [cytosol]
(R-HSA-9818584)
KMT2A(2719-3969) [cytosol]
(R-HSA-9818590)
KMT2A(1-2718) [cytosol]
(R-HSA-9818597)
KMT2A [nucleoplasm]
(R-HSA-1183223)
KMT2A(1-2718) [nucleoplasm]
(R-HSA-9818591)
KMT2A(2719-3969) [nucleoplasm]
(R-HSA-9818593)
0.643
3
UniProt:P35579 MYH9
3
MYH9 [cytosol]
(R-HSA-419173)
MYH9(2-1644)-ALK(1067-1620) fusion [cytosol]
(R-HSA-9715280)
MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol]
(R-HSA-9715279)
0.556
3
UniProt:Q9BXW9 FANCD2
3
p-T691,S717-FANCD2 [nucleoplasm]
(R-HSA-6788481)
MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm]
(R-HSA-6785318)
FANCD2 [nucleoplasm]
(R-HSA-419522)
0.524
4
UniProt:P19838-PRO_0000030311 NFKB1
0.524
2
UniProt:Q9UMN6 KMT2B
5
KMT2B [cytosol]
(R-HSA-9818624)
KMT2B(2-2062) [cytosol]
(R-HSA-9818621)
KMT2B(2063-2715) [cytosol]
(R-HSA-9818626)
KMT2B(2063-2715) [nucleoplasm]
(R-HSA-9818623)
KMT2B(2-2062) [nucleoplasm]
(R-HSA-9818620)
0.462
2
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