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RNF111 [nucleoplasm]
Stable Identifier
R-HSA-2186765
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
E3 ubiquitin-protein ligase Arkadia, RN111_HUMAN
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
Formation of Incision Complex in GG-NER (Homo sapiens)
RNF111 ubiquitinates SUMOylated XPC (Homo sapiens)
RNF111 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL (Homo sapiens)
RNF111/SMURF2 [nucleoplasm] (Homo sapiens)
RNF111 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCOR:RNF111/SMURF2 [nucleoplasm] (Homo sapiens)
RNF111/SMURF2 [nucleoplasm] (Homo sapiens)
RNF111 [nucleoplasm] (Homo sapiens)
Ubiquitination of SKI/SKIL by RNF111/SMURF2 (Homo sapiens)
RNF111/SMURF2 [nucleoplasm] (Homo sapiens)
RNF111 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCOR:RNF111/SMURF2 [nucleoplasm] (Homo sapiens)
RNF111/SMURF2 [nucleoplasm] (Homo sapiens)
RNF111 [nucleoplasm] (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
RNF111 binds SMAD7 (Homo sapiens)
RNF111 [nucleoplasm] (Homo sapiens)
SMAD7:RNF111 [nucleoplasm] (Homo sapiens)
RNF111 [nucleoplasm] (Homo sapiens)
RNF111 ubiquitinates SMAD7 (Homo sapiens)
RNF111 [nucleoplasm] (Homo sapiens)
SMAD7:RNF111 [nucleoplasm] (Homo sapiens)
RNF111 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL (Homo sapiens)
RNF111/SMURF2 [nucleoplasm] (Homo sapiens)
RNF111 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCOR:RNF111/SMURF2 [nucleoplasm] (Homo sapiens)
RNF111/SMURF2 [nucleoplasm] (Homo sapiens)
RNF111 [nucleoplasm] (Homo sapiens)
Ubiquitination of SKI/SKIL by RNF111/SMURF2 (Homo sapiens)
RNF111/SMURF2 [nucleoplasm] (Homo sapiens)
RNF111 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCOR:RNF111/SMURF2 [nucleoplasm] (Homo sapiens)
RNF111/SMURF2 [nucleoplasm] (Homo sapiens)
RNF111 [nucleoplasm] (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
RNF111 binds SMAD7 (Homo sapiens)
RNF111 [nucleoplasm] (Homo sapiens)
SMAD7:RNF111 [nucleoplasm] (Homo sapiens)
RNF111 [nucleoplasm] (Homo sapiens)
RNF111 ubiquitinates SMAD7 (Homo sapiens)
RNF111 [nucleoplasm] (Homo sapiens)
SMAD7:RNF111 [nucleoplasm] (Homo sapiens)
RNF111 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6ZNA4 RNF111
Gene Names
RNF111
Chain
chain:1-994
Reference Genes
BioGPS Gene:54778 RNF111
COSMIC (genes):RNF111 RNF111
CTD Gene:54778 RNF111
dbSNP Gene:54778 RNF111
ENSEMBL:ENSG00000157450 RNF111
HGNC:17384 RNF111
KEGG Gene (Homo sapiens):54778 RNF111
Monarch:54778 RNF111
NCBI Gene:54778 RNF111
OMIM:605840 RNF111
UCSC:Q6ZNA4 RNF111
Reference Transcript
RefSeq:NM_001270530.1 RNF111
RefSeq:XM_017022338.1 RNF111
RefSeq:XM_006720579.3 RNF111
RefSeq:NM_017610.7 RNF111
RefSeq:NM_001270529.1 RNF111
RefSeq:NM_001270528.1 RNF111
RefSeq:NM_001330331.1 RNF111
Other Identifiers
0000460193
11719768_at
11719769_a_at
11757911_s_at
16801529
218761_at
3595910
3595912
3595913
3595914
3595915
3595926
3595930
3595931
3595932
3595933
3595939
3595940
3595941
3595942
3595944
3595946
3595951
3595952
3595955
3595957
3595959
3595962
3595965
3595966
3595967
3595968
3595969
3595970
3595971
3595972
3595973
3595974
53754_at
54778
7983953
A_14_P103966
A_14_P133695
A_23_P77160
GE56832
GO:0000209
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006259
GO:0006281
GO:0006464
GO:0006511
GO:0006950
GO:0006974
GO:0007165
GO:0007275
GO:0007389
GO:0008150
GO:0009056
GO:0009058
GO:0016567
GO:0016605
GO:0016740
GO:0030511
GO:0030579
GO:0031398
GO:0032182
GO:0032184
GO:0032991
GO:0034641
GO:0043167
GO:0043226
GO:0045893
GO:0045944
GO:0046332
GO:0046872
GO:0048856
GO:0061630
GO:0070911
HMNXSV003049500
ILMN_1760209
ILMN_1767454
PH_hs_0028765
TC15000448.hg
g8922164_3p_at
Participates
as a candidate of
RNF111/SMURF2 [nucleoplasm] (Homo sapiens)
as an input of
RNF111 binds SMAD7 (Homo sapiens)
as an output of
RNF111 ubiquitinates SMAD7 (Homo sapiens)
as a component of
SMAD7:RNF111 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
RNF111 [cytosol]
Inferred To
rnf111 [nucleoplasm]
(Danio rerio)
rnf111 [nucleoplasm]
(Xenopus tropicalis)
RNF111 [nucleoplasm]
(Bos taurus)
RNF111 [nucleoplasm]
(Canis familiaris)
RNF111 [nucleoplasm]
(Gallus gallus)
RNF111 [nucleoplasm]
(Sus scrofa)
Rnf111 [nucleoplasm]
(Mus musculus)
Rnf111 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_001257458.1
,
NP_001317260.1
,
XP_006720642.1
,
NP_001257459.1
,
NP_001257457.1
,
NP_060080.6
,
XP_016877827.1
OpenTargets
ENSG00000157450
HPA
ENSG00000157450-RNF111
GeneCards
Q6ZNA4
Ensembl
ENST00000348370
,
ENSP00000452732
,
ENSP00000453015
,
ENST00000561186
,
ENSP00000453872
,
ENSG00000157450
,
ENST00000559209
,
ENSP00000288199
,
ENST00000557998
PRO
Q6ZNA4
PDB
5LG7
,
5LG0
,
2KIZ
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61077 UBE2D3
3
Ub-C85-UBE2D3 [cytosol]
(R-HSA-8864191)
UBE2D3 [nucleoplasm]
(R-HSA-205341)
UBE2D3 [cytosol]
(R-HSA-934630)
0.742
5
UniProt:P63279 UBE2I
8
UBE2I [nuclear envelope]
(R-HSA-4655408)
SUMO1-K14-UBE2I [nucleoplasm]
(R-HSA-4085358)
UBE2I [cytosol]
(R-HSA-4655342)
SUMO1-C93-UBE2I [cytosol]
(R-HSA-4656909)
SUMO3-C93-UBE2I [nucleoplasm]
(R-HSA-3730629)
SUMO2-C93-UBE2I [nucleoplasm]
(R-HSA-3730619)
UBE2I [nucleoplasm]
(R-HSA-912481)
SUMO1-C93-UBE2I [nucleoplasm]
(R-HSA-3730617)
0.742
5
UniProt:P51668 UBE2D1
3
UBE2D1 [nucleoplasm]
(R-HSA-174197)
Ub-C85-UBE2D1 [cytosol]
(R-HSA-8864160)
UBE2D1 [cytosol]
(R-HSA-174236)
0.742
5
UniProt:P68400 CSNK2A1
2
CSNK2A1 [cytosol]
(R-HSA-201713)
CSNK2A1 [nucleoplasm]
(R-HSA-6805057)
0.742
5
UniProt:P26371 KRTAP5-9
1
KRTAP5-9 [cytosol]
(R-HSA-6810265)
0.742
5
UniProt:Q13404 UBE2V1
1
UBE2V1 [cytosol]
(R-HSA-205753)
0.592
2
UniProt:B2R8Y4 B2R8Y4
0.556
3
UniProt:Q8WWZ3 EDARADD
1
EDARADD [cytosol]
(R-HSA-5675659)
0.556
3
UniProt:Q5TA78 LCE4A
1
LCE4A [cytosol]
(R-HSA-6814272)
0.556
3
UniProt:Q969T4 UBE2E3
4
Ub-C145-UBE2E3 [nucleoplasm]
(R-HSA-8864208)
Ub-C145-UBE2E3 [cytosol]
(R-HSA-8864162)
UBE2E3 [nucleoplasm]
(R-HSA-8852108)
UBE2E3 [cytosol]
(R-HSA-947633)
0.553
2
UniProt:P51965 UBE2E1
5
UBE2E1 [nucleoplasm]
(R-HSA-8852073)
Ub-C131-UBE2E1 [nucleoplasm]
(R-HSA-8864185)
Ub-C131-UBE2E1 [cytosol]
(R-HSA-8864219)
UBE2E1 [nucleoplasm]
(R-HSA-174063)
UBE2E1 [cytosol]
(R-HSA-174100)
0.553
2
UniProt:Q96B02 UBE2W
3
UBE2W [nucleoplasm]
(R-HSA-8852057)
Ub-C91-UBE2W [nucleoplasm]
(R-HSA-8864205)
UBE2W [cytosol]
(R-HSA-947639)
0.553
2
UniProt:P62837 UBE2D2
4
Ub-C85-UBE2D2 [cytosol]
(R-HSA-8864214)
Ub-C85-UBE2D2 [nucleoplasm]
(R-HSA-8864153)
UBE2D2 [nucleoplasm]
(R-HSA-8852067)
UBE2D2 [cytosol]
(R-HSA-934628)
0.553
2
UniProt:Q9Y2X8 UBE2D4
1
UBE2D4 [cytosol]
(R-HSA-947623)
0.553
2
UniProt:Q6ZNA4 RNF111
2
RNF111 [cytosol]
(R-HSA-975981)
RNF111 [nucleoplasm]
(R-HSA-2186765)
0.553
2
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