Reactome | RNF111 [nucleoplasm]

RNF111 [nucleoplasm]

Stable Identifier

R-HSA-2186765

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

E3 ubiquitin-protein ligase Arkadia, RN111_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q6ZNA4 RNF111

Gene Names

RNF111

Chain

chain:1-994

Reference Genes

BioGPS Gene:54778 RNF111

COSMIC (genes):RNF111 RNF111

CTD Gene:54778 RNF111

dbSNP Gene:54778 RNF111

ENSEMBL:ENSG00000157450 RNF111

HGNC:17384 RNF111

KEGG Gene (Homo sapiens):54778 RNF111

Monarch:54778 RNF111

NCBI Gene:54778 RNF111

OMIM:605840 RNF111

UCSC:Q6ZNA4 RNF111

Reference Transcript

Other Identifiers

0000460193

11719768_at

11719769_a_at

11757911_s_at

16801529

218761_at

3595910

3595912

3595913

3595914

3595915

3595926

3595930

3595931

3595932

3595933

3595939

3595940

3595941

3595942

3595944

3595946

3595951

3595952

3595955

3595957

3595959

3595962

3595965

3595966

3595967

3595968

3595969

3595970

3595971

3595972

3595973

3595974

53754_at

54778

7983953

A_14_P103966

A_14_P133695

A_23_P77160

GE56832

GO:0000209

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006259

GO:0006281

GO:0006464

GO:0006511

GO:0006950

GO:0006974

GO:0007165

GO:0007275

GO:0007389

GO:0008150

GO:0009056

GO:0009058

GO:0016567

GO:0016605

GO:0016740

GO:0030511

GO:0030579

GO:0031398

GO:0032182

GO:0032184

GO:0032991

GO:0034641

GO:0043167

GO:0043226

GO:0045893

GO:0045944

GO:0046332

GO:0046872

GO:0048856

GO:0061630

GO:0070911

HMNXSV003049500

ILMN_1760209

ILMN_1767454

PH_hs_0028765

TC15000448.hg

g8922164_3p_at

Participates

as a candidate of

RNF111/SMURF2 [nucleoplasm] (Homo sapiens)

as an input of

RNF111 binds SMAD7 (Homo sapiens)

as an output of

RNF111 ubiquitinates SMAD7 (Homo sapiens)

as a component of

SMAD7:RNF111 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

RNF111 [cytosol]

Inferred To

rnf111 [nucleoplasm] (Danio rerio)

rnf111 [nucleoplasm] (Xenopus tropicalis)

RNF111 [nucleoplasm] (Bos taurus)

RNF111 [nucleoplasm] (Canis familiaris)

RNF111 [nucleoplasm] (Gallus gallus)

RNF111 [nucleoplasm] (Sus scrofa)

Rnf111 [nucleoplasm] (Mus musculus)

Rnf111 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001257458.1, NP_001317260.1, XP_006720642.1, NP_001257459.1, NP_001257457.1, NP_060080.6, XP_016877827.1

OpenTargets

ENSG00000157450

HPA

ENSG00000157450-RNF111

GeneCards

Q6ZNA4

Ensembl

ENST00000348370, ENSP00000452732, ENSP00000453015, ENST00000561186, ENSP00000453872, ENSG00000157450, ENST00000559209, ENSP00000288199, ENST00000557998

PRO

Q6ZNA4

PDB

5LG7, 5LG0, 2KIZ

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61077 UBE2D3	3	Ub-C85-UBE2D3 [cytosol] (R-HSA-8864191) UBE2D3 [nucleoplasm] (R-HSA-205341) UBE2D3 [cytosol] (R-HSA-934630)	0.742	5
UniProt:P63279 UBE2I	8	UBE2I [nuclear envelope] (R-HSA-4655408) SUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [cytosol] (R-HSA-4655342) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) UBE2I [nucleoplasm] (R-HSA-912481) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617)	0.742	5
UniProt:P51668 UBE2D1	3	UBE2D1 [nucleoplasm] (R-HSA-174197) Ub-C85-UBE2D1 [cytosol] (R-HSA-8864160) UBE2D1 [cytosol] (R-HSA-174236)	0.742	5
UniProt:P68400 CSNK2A1	2	CSNK2A1 [cytosol] (R-HSA-201713) CSNK2A1 [nucleoplasm] (R-HSA-6805057)	0.742	5
UniProt:P26371 KRTAP5-9	1	KRTAP5-9 [cytosol] (R-HSA-6810265)	0.742	5
UniProt:Q13404 UBE2V1	1	UBE2V1 [cytosol] (R-HSA-205753)	0.592	2
UniProt:B2R8Y4 B2R8Y4			0.556	3
UniProt:Q8WWZ3 EDARADD	1	EDARADD [cytosol] (R-HSA-5675659)	0.556	3
UniProt:Q5TA78 LCE4A	1	LCE4A [cytosol] (R-HSA-6814272)	0.556	3
UniProt:Q969T4 UBE2E3	4	Ub-C145-UBE2E3 [nucleoplasm] (R-HSA-8864208) Ub-C145-UBE2E3 [cytosol] (R-HSA-8864162) UBE2E3 [nucleoplasm] (R-HSA-8852108) UBE2E3 [cytosol] (R-HSA-947633)	0.553	2
UniProt:P51965 UBE2E1	5	UBE2E1 [nucleoplasm] (R-HSA-8852073) Ub-C131-UBE2E1 [nucleoplasm] (R-HSA-8864185) Ub-C131-UBE2E1 [cytosol] (R-HSA-8864219) UBE2E1 [nucleoplasm] (R-HSA-174063) UBE2E1 [cytosol] (R-HSA-174100)	0.553	2
UniProt:Q96B02 UBE2W	3	UBE2W [nucleoplasm] (R-HSA-8852057) Ub-C91-UBE2W [nucleoplasm] (R-HSA-8864205) UBE2W [cytosol] (R-HSA-947639)	0.553	2
UniProt:P62837 UBE2D2	4	Ub-C85-UBE2D2 [cytosol] (R-HSA-8864214) Ub-C85-UBE2D2 [nucleoplasm] (R-HSA-8864153) UBE2D2 [nucleoplasm] (R-HSA-8852067) UBE2D2 [cytosol] (R-HSA-934628)	0.553	2
UniProt:Q9Y2X8 UBE2D4	1	UBE2D4 [cytosol] (R-HSA-947623)	0.553	2
UniProt:Q6ZNA4 RNF111	2	RNF111 [cytosol] (R-HSA-975981) RNF111 [nucleoplasm] (R-HSA-2186765)	0.553	2

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