Reactome | RNF111 [nucleoplasm]

RNF111 [nucleoplasm]

Stable Identifier

R-HSA-2186765

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

E3 ubiquitin-protein ligase Arkadia, RN111_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9Y2X8 UBE2D4

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External Reference Information

External Reference

UniProt:Q6ZNA4 RNF111

Gene Names

RNF111

Chain

chain:1-994

Reference Genes

BioGPS Gene:54778 Q6ZNA42

COSMIC (genes):RNF111 RNF111

CTD Gene:54778 Q6ZNA42

dbSNP Gene:54778 Q6ZNA42

ENSEMBL:ENSG00000157450 RNF111

HGNC:17384 Q6ZNA42

KEGG:hsa:54778 Q6ZNA42

Monarch:54778 Q6ZNA42

NCBI Gene:54778 Q6ZNA42

OMIM:605840 Q6ZNA42

UCSC:Q6ZNA4 Q6ZNA42

Reference Transcript

Participates

as an input of

RNF111 binds SMAD7 (Homo sapiens)

as an output of

RNF111 ubiquitinates SMAD7 (Homo sapiens)

as a component of

SMAD7:RNF111 [nucleoplasm] (Homo sapiens)

as a candidate of

RNF111/SMURF2 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

RNF111 [cytosol]

Inferred To

RNF111 [nucleoplasm] (Bos taurus)

RNF111 [nucleoplasm] (Canis familiaris)

RNF111 [nucleoplasm] (Gallus gallus)

RNF111 [nucleoplasm] (Mus musculus)

RNF111 [nucleoplasm] (Sus scrofa)

RNF111 [nucleoplasm] (Xenopus tropicalis)

Rnf111 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

XP_016877831.1, XP_006720642.1, NP_001257459.1, NP_001257458.1, NP_001257457.1, XP_016877827.1, NP_001317260.1, NP_060080.6

OpenTargets

ENSG00000157450

ENSEMBL

ENSP00000453872, ENSG00000157450, ENST00000557998, ENST00000559209, ENSP00000288199, ENST00000561186, ENSP00000453015, ENST00000348370, ENSP00000452732

HPA

ENSG00000157450-RNF111

GeneCards

RNF111

PRO

Q6ZNA4

Pharos - Targets

Q6ZNA4

GlyGen

Q6ZNA4

HMDB Protein

HMDBP14477

PDB

2KIZ, 5LG7, 7P2K, 5LG0

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P68400 CSNK2A1	2	CSNK2A1 [cytosol] (R-HSA-201713) CSNK2A1 [nucleoplasm] (R-HSA-6805057)	0.848	7
UniProt:P51668 UBE2D1	4	UBE2D1 [cytosol] (R-HSA-174236) UBE2D1 [nucleoplasm] (R-HSA-174197) Ub-C85-UBE2D1 [cytosol] (R-HSA-8864160) Ub-C85-UBE2D1 [nucleoplasm] (R-HSA-8937534)	0.742	5
UniProt:P26371 KRTAP5-9	1	KRTAP5-9 [cytosol] (R-HSA-6810265)	0.742	5
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [nucleoplasm] (R-HSA-912481) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) UBE2I [cytosol] (R-HSA-4655342) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944)	0.742	5
UniProt:P61077 UBE2D3	3	Ub-C85-UBE2D3 [cytosol] (R-HSA-8864191) UBE2D3 [cytosol] (R-HSA-934630) UBE2D3 [nucleoplasm] (R-HSA-205341)	0.742	5
UniProt:Q13404 UBE2V1	1	UBE2V1 [cytosol] (R-HSA-205753)	0.592	2
UniProt:Q8WWZ3 EDARADD	1	EDARADD [cytosol] (R-HSA-5675659)	0.556	3
UniProt:Q5TA78 LCE4A	1	LCE4A [cytosol] (R-HSA-6814272)	0.556	3
UniProt:B2R8Y4 B2R8Y4			0.556	3
UniProt:Q6ZNA4 RNF111	2	RNF111 [nucleoplasm] (R-HSA-2186765) RNF111 [cytosol] (R-HSA-975981)	0.553	2
UniProt:P62837 UBE2D2	4	Ub-C85-UBE2D2 [cytosol] (R-HSA-8864214) UBE2D2 [cytosol] (R-HSA-934628) UBE2D2 [nucleoplasm] (R-HSA-8852067) Ub-C85-UBE2D2 [nucleoplasm] (R-HSA-8864153)	0.553	2
UniProt:Q9Y2X8 UBE2D4	1	UBE2D4 [cytosol] (R-HSA-947623)	0.553	2
UniProt:Q96B02 UBE2W	3	Ub-C91-UBE2W [nucleoplasm] (R-HSA-8864205) UBE2W [nucleoplasm] (R-HSA-8852057) UBE2W [cytosol] (R-HSA-947639)	0.553	2
UniProt:P51965 UBE2E1	4	Ub-C131-UBE2E1 [nucleoplasm] (R-HSA-8864185) Ub-C131-UBE2E1 [cytosol] (R-HSA-8864219) UBE2E1 [nucleoplasm] (R-HSA-174063) UBE2E1 [cytosol] (R-HSA-174100)	0.553	2
UniProt:Q969T4 UBE2E3	4	Ub-C145-UBE2E3 [cytosol] (R-HSA-8864162) Ub-C145-UBE2E3 [nucleoplasm] (R-HSA-8864208) UBE2E3 [nucleoplasm] (R-HSA-8852108) UBE2E3 [cytosol] (R-HSA-947633)	0.553	2
UniProt:P67870 CSNK2B	5	CSNK2B [cytosol] (R-HSA-201693) CSNK2B [nucleoplasm] (R-HSA-6805067) CSNK2B [ficolin-1-rich granule lumen] (R-HSA-6801290) CSNK2B [extracellular region] (R-HSA-6806508) CSNK2B [secretory granule lumen] (R-HSA-6801319)	0.527	3
UniProt:P19784 CSNK2A2	2	CSNK2A2 [cytosol] (R-HSA-201721) CSNK2A2 [nucleoplasm] (R-HSA-6805065)	0.527	2

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