Reactome | RibC-SMAD4 [nucleoplasm]

RibC-SMAD4 [nucleoplasm]

Stable Identifier

R-HSA-2187323

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

PAR-SMAD4, ADP-D-ribosyl-SMAD4, PARylated SMAD4

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Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
      - Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
        
        PARP1 ADP-ribosylates SMAD3 and SMAD4 (Homo sapiens)
        
        PAR-SMAD2/3:PAR-SMAD4 [nucleoplasm] (Homo sapiens)
        
        RibC-SMAD4 [nucleoplasm] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by TGF-beta family members (Homo sapiens)
  - Signaling by TGF-beta Receptor Complex (Homo sapiens)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
      - Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
        
        PARP1 ADP-ribosylates SMAD3 and SMAD4 (Homo sapiens)
        
        PAR-SMAD2/3:PAR-SMAD4 [nucleoplasm] (Homo sapiens)
        
        RibC-SMAD4 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13485 SMAD4

Gene Names

SMAD4, DPC4, MADH4

Chain

chain:1-552

Reference Genes

BioGPS Gene:4089 SMAD4

COSMIC (genes):SMAD4 SMAD4

CTD Gene:4089 SMAD4

dbSNP Gene:4089 SMAD4

ENSEMBL:ENSG00000141646 SMAD4

HGNC:6770 SMAD4

KEGG Gene (Homo sapiens):4089 SMAD4

Monarch:4089 SMAD4

NCBI Gene:4089 SMAD4

OMIM:600993 SMAD4

UCSC:Q13485 SMAD4

Reference Transcript

RefSeq:NM_005359.5 SMAD4

Other Identifiers

0000540341

11725360_a_at

11725361_s_at

11725362_x_at

11725363_s_at

11744679_a_at

11750827_a_at

11753117_a_at

16852354

19154

1DD1

1G88

1MR1

1U7F

1U7V

1YGS

202526_at

202527_s_at

235725_at

36953_at

3788304

3788305

3788306

3788307

3788308

3788315

3788316

3788318

3788320

3788324

3788327

3788328

3788330

3788335

3788337

3788344

3788346

3788347

3788348

3788349

3788350

3788351

3788353

3788355

3788357

3788358

3788359

4089

46885_at

509_at

510_g_at

57902_at

58962_at

5C4V

5MEY

5MEZ

5MF0

5UWU

74813_at

8021228

A0A024R274

A_14_P134632

A_19_P00323665

A_19_P00804817

A_19_P00812250

A_23_P27346

AAA91041

AAC03051

AAH02379

AF045438

AF045439

AF045440

AF045441

AF045442

AF045443

AF045444

AF045445

AF045446

AF045447

AK290770

ALQ33626

BAF83459

BC002379

CCDS11950

CH471096

EAW62985

EAW62986

EAW62987

ENSG00000141646

ENSP00000341551

ENSP00000381452

ENST00000342988

ENST00000342988.7

ENST00000398417

ENST00000398417.6

EntrezGene:4089

EntrezGene:SMAD4

g4885456_3p_a_at

GE59174

GE887174

GO:0000003

GO:0000122

GO:0000228

GO:0000790

GO:0000902

GO:0000977

GO:0000978

GO:0000981

GO:0000987

GO:0001085

GO:0001228

GO:0001541

GO:0001658

GO:0001666

GO:0001701

GO:0001702

GO:0001822

GO:0003148

GO:0003190

GO:0003198

GO:0003220

GO:0003251

GO:0003279

GO:0003360

GO:0003674

GO:0003677

GO:0003682

GO:0003700

GO:0003712

GO:0005515

GO:0005518

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006355

GO:0006357

GO:0006464

GO:0006810

GO:0006879

GO:0006950

GO:0007010

GO:0007165

GO:0007179

GO:0007183

GO:0007267

GO:0007283

GO:0007338

GO:0007369

GO:0007411

GO:0007492

GO:0007498

GO:0008134

GO:0008150

GO:0008219

GO:0008283

GO:0008285

GO:0008584

GO:0008585

GO:0009058

GO:0009653

GO:0009790

GO:0009952

GO:0010614

GO:0010718

GO:0010862

GO:0014033

GO:0016579

GO:0017015

GO:0022607

GO:0030154

GO:0030308

GO:0030509

GO:0030511

GO:0030513

GO:0030616

GO:0032444

GO:0032525

GO:0032909

GO:0032991

GO:0033686

GO:0034641

GO:0035019

GO:0035556

GO:0036302

GO:0040007

GO:0040011

GO:0042118

GO:0042127

GO:0042592

GO:0042733

GO:0042802

GO:0042803

GO:0043167

GO:0043199

GO:0043226

GO:0043565

GO:0044212

GO:0045892

GO:0045893

GO:0045944

GO:0046872

GO:0046881

GO:0046982

GO:0048382

GO:0048589

GO:0048646

GO:0048663

GO:0048729

GO:0048733

GO:0048856

GO:0048859

GO:0051098

GO:0051276

GO:0051571

GO:0051797

GO:0060065

GO:0060391

GO:0060395

GO:0060412

GO:0060548

GO:0060956

GO:0061040

GO:0061614

GO:0062009

GO:0065003

GO:0070102

GO:0070207

GO:0070373

GO:0070411

GO:0070412

GO:0071141

GO:0071559

GO:0071773

GO:0072133

GO:0072134

GO:0072520

GO:0090575

GO:0098772

GO:1901522

GO:1905305

GO:2000617

HGNC:6770

HPA019154

Hs.50438.0.A1_3p_at

Hs.75862.0.S2_3p_at

ILMN_1741477

ILMN_1842785

IPR001132

IPR003619

IPR008984

IPR013019

IPR013790

IPR017855

IPR036578

K7EIJ2

K7EIU8

K7EL15

K7EL18

K7ELK2

K7ENG1

K7ENG8

K7ES96

KU178168

LRG_318

LRG_318t1

MIM:139210

MIM:174900

MIM:175050

MIM:260350

MIM:600993

NM_005359

NP_005350

PF03165

PF03166

PH_hs_0004380

SM00523

SM00524

SMAD4

SMAD4-201

SMAD4-202

TC18000998.hg

U44378

U44378_at

UPI0000053431

Participant Of

hasComponent

PAR-SMAD2/3:PAR-SMAD4 [nucleoplasm]

Other forms of this molecule

SMAD4 P356R [cytosol]

SMAD4 K428T [cytosol]

SMAD4 D351del [cytosol]

SMAD4 R361H [cytosol]

SMAD4 P356L [cytosol]

SMAD4 A406T [cytosol]

SMAD4 D351Y [cytosol]

SMAD4 D351H [cytosol]

SMAD4 [nucleoplasm]

SMAD4 [cytosol]

SMAD4 R361S [cytosol]

SMAD4 R361G [cytosol]

SMAD4 R515* [cytosol]

SMAD4 K428R [cytosol]

SMAD4 R515T [cytosol]

SMAD4 D351G [cytosol]

SMAD4 R361C [cytosol]

Inferred To

phospho-RibC-SMAD4 [nucleoplasm] (Canis familiaris)

phospho-RibC-SMAD4 [nucleoplasm] (Danio rerio)

phospho-RibC-SMAD4 [nucleoplasm] (Drosophila melanogaster)

phospho-RibC-SMAD4 [nucleoplasm] (Gallus gallus)

phospho-RibC-SMAD4 [nucleoplasm] (Mus musculus)

phospho-RibC-SMAD4 [nucleoplasm] (Rattus norvegicus)

phospho-RibC-SMAD4 [nucleoplasm] (Sus scrofa)

phospho-RibC-SMAD4 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

adenosine diphosphoribosyl (ADP-ribosyl) modified residue at unknown position

PsiMod Name

adenosine diphosphoribosyl (ADP-ribosyl) modified residue

PsiMod Definition

A protein modification that effectively results from forming an adduct with ADP-ribose through formation of a glycosidic bond.

Cross References

RefSeq

NP_005350.1

OpenTargets

ENSG00000141646

GeneCards

Q13485

PRO

Q13485

Orphanet

15524

PDB

1YGS, 5MEZ, 1U7F, 1U7V, 5MF0, 5MEY, 5C4V, 1DD1, 5UWU, 1G88, 1MR1

Interactors (32)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P84022 SMAD3	12	p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 S425F [cytosol] (R-HSA-8944158) p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855) SMAD3 [nucleoplasm] (R-HSA-206150) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) SMAD3 S425C [cytosol] (R-HSA-3308499)	0.972	25
UniProt:Q15796 SMAD2	15	p-S465,S467-SMAD2 P305L [cytosol] (R-HSA-3315471) Ub-SMAD2 [cytosol] (R-HSA-6782774) p-S465,S467-SMAD2 D300A [cytosol] (R-HSA-3315064) p-S465,S467-SMAD2 D300N [cytosol] (R-HSA-3315066) p-S465,S467-SMAD2 A354T [cytosol] (R-HSA-3315474) p-S465,S467-SMAD2 P305Q [cytosol] (R-HSA-3315070) p-S465,S467-SMAD2 D300V [cytosol] (R-HSA-3315067) SMAD2 S464* [cytosol] (R-HSA-3304362) p-S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009185) p-S465,S467-SMAD2 [cytosol] (R-HSA-3009186) SMAD2 [cytosol] (R-HSA-3006353) SMAD2 [nucleoplasm] (R-HSA-3006352) p-T220,S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009189) SMAD2 S467P [cytosol] (R-HSA-3304375) SMAD2 S464L [cytosol] (R-HSA-3304383)	0.957	21
UniProt:Q15797 SMAD1	4	p-S463,S465-SMAD1 [cytosol] (R-HSA-201464) p-S463,S465-SMAD1 [nucleoplasm] (R-HSA-201483) SMAD1 [cytosol] (R-HSA-201468) Ub-SMAD1 [cytosol] (R-HSA-6782768)	0.942	11
UniProt:P12755 SKI	1	SKI [nucleoplasm] (R-HSA-173473)	0.91	13
UniProt:Q9NPI6 DCP1A	1	DCP1A [cytosol] (R-HSA-430043)	0.779	5
UniProt:Q9UPN9 TRIM33	1	TRIM33 [nucleoplasm] (R-HSA-870522)	0.748	6
UniProt:O43524 FOXO3	9	p-S215 FOXO3 [cytosol] (R-HSA-5687014) p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010) FOXO3 [nucleoplasm] (R-HSA-199305) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) FOXO3 [cytosol] (R-HSA-5687032)	0.743	9
UniProt:P63279 UBE2I	8	SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) UBE2I [cytosol] (R-HSA-4655342) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) UBE2I [nucleoplasm] (R-HSA-912481) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617)	0.721	4
UniProt:Q9UBE8 NLK	3	p-T298-NLK [cytosol] (R-HSA-4411398) NLK [cytosol] (R-HSA-4411330) p-T298-NLK [nucleoplasm] (R-HSA-4411376)	0.719	6
UniProt:P61968 LMO4			0.696	5
UniProt:P17676 CEBPB	3	p-T235-CEBPB [nucleoplasm] (R-HSA-3857343) p-T235, S321-CEBPB [nucleoplasm] (R-HSA-3857339) CEBPB [nucleoplasm] (R-HSA-381378)	0.609	2
UniProt:Q92988 DLX4			0.602	5
UniProt:P70398	1	USP9X [cytosol] (R-MMU-870499)	0.602	4
UniProt:P24468 NR2F2	1	NR2F2 [nucleoplasm] (R-HSA-1183002)	0.591	4
UniProt:Q8WWW0 RASF5			0.556	3
UniProt:O75925 PIAS1	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.553	2
UniProt:Q6VMQ6 ATF7IP	1	ATF7IP [nucleoplasm] (R-HSA-3301918)	0.553	2
UniProt:P12757 SKIL	1	SKIL [nucleoplasm] (R-HSA-2186596)	0.547	3
UniProt:O15198 SMAD9	3	p-S465,S467-SMAD9 [nucleoplasm] (R-HSA-201474) SMAD9 [cytosol] (R-HSA-201478) p-S465,S467-SMAD9 [cytosol] (R-HSA-201441)	0.547	2
UniProt:Q13485 SMAD4	18	SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 [nucleoplasm] (R-HSA-177103) SMAD4 [cytosol] (R-HSA-170862) RibC-SMAD4 [nucleoplasm] (R-HSA-2187323) SMAD4 R361S [cytosol] (R-HSA-3310994) SMAD4 R361G [cytosol] (R-HSA-3310993) SMAD4 R515* [cytosol] (R-HSA-3311012) SMAD4 K428R [cytosol] (R-HSA-3311001) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R361C [cytosol] (R-HSA-3310983)	0.547	3
UniProt:SMAD7 ENSG00000101665			0.527	3
UniProt:Q9UI36 DACH1			0.524	3
UniProt:P98177 FOXO4	8	Ac-K-FOXO4 [nucleoplasm] (R-HSA-9617761) PolyUb-FOXO4 [nucleoplasm] (R-HSA-6782501) EP300-S-S-FOXO4 [nucleoplasm] (R-HSA-9617681) CREBBP-S-S-FOXO4 [nucleoplasm] (R-HSA-9617679) SOH-C481-FOXO4 [nucleoplasm] (R-HSA-9617655) p-T32,S197,S262-FOXO4 [cytosol] (R-HSA-9614415) p-T32,S197,S262-FOXO4 [nucleoplasm] (R-HSA-199314) FOXO4 [nucleoplasm] (R-HSA-5690183)	0.524	2
UniProt:P23769 GATA2	1	GATA2 [nucleoplasm] (R-HSA-996735)	0.508	2
IntAct:EBI-11165649 P21			0.499	2
UniProt:P70056 FOXH1			0.499	2
UniProt:Q15915 ZIC1			0.488	2
UniProt:O15198-2 SMAD9			0.488	2
UniProt:P43268-3 ETV4			0.488	2
UniProt:Q8NI38 IKBD			0.488	2
UniProt:Q96F07 CYFIP2	1	CYFIP2 [cytosol] (R-HSA-1671642)	0.488	2
UniProt:Q08117-2 TLE5			0.488	2