Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
RibC-SMAD4 [nucleoplasm]
Stable Identifier
R-HSA-2187323
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
PAR-SMAD4, ADP-D-ribosyl-SMAD4, PARylated SMAD4
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Homo sapiens)
PAR-SMAD2/3:PAR-SMAD4 [nucleoplasm] (Homo sapiens)
RibC-SMAD4 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGF-beta family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Homo sapiens)
PAR-SMAD2/3:PAR-SMAD4 [nucleoplasm] (Homo sapiens)
RibC-SMAD4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13485 SMAD4
Gene Names
SMAD4, DPC4, MADH4
Chain
chain:1-552
Reference Genes
BioGPS Gene:4089 SMAD4
COSMIC (genes):SMAD4 SMAD4
CTD Gene:4089 SMAD4
dbSNP Gene:4089 SMAD4
ENSEMBL:ENSG00000141646 SMAD4
HGNC:6770 SMAD4
KEGG Gene (Homo sapiens):4089 SMAD4
Monarch:4089 SMAD4
NCBI Gene:4089 SMAD4
OMIM:600993 SMAD4
UCSC:Q13485 SMAD4
Reference Transcript
RefSeq:NM_005359.5 SMAD4
Other Identifiers
0000540341
11725360_a_at
11725361_s_at
11725362_x_at
11725363_s_at
11744679_a_at
11750827_a_at
11753117_a_at
16852354
19154
1DD1
1G88
1MR1
1U7F
1U7V
1YGS
202526_at
202527_s_at
235725_at
36953_at
3788304
3788305
3788306
3788307
3788308
3788315
3788316
3788318
3788320
3788324
3788327
3788328
3788330
3788335
3788337
3788344
3788346
3788347
3788348
3788349
3788350
3788351
3788353
3788355
3788357
3788358
3788359
4089
46885_at
509_at
510_g_at
57902_at
58962_at
5C4V
5MEY
5MEZ
5MF0
5UWU
74813_at
8021228
A0A024R274
A_14_P134632
A_19_P00323665
A_19_P00804817
A_19_P00812250
A_23_P27346
AAA91041
AAC03051
AAH02379
AF045438
AF045439
AF045440
AF045441
AF045442
AF045443
AF045444
AF045445
AF045446
AF045447
AK290770
ALQ33626
BAF83459
BC002379
CCDS11950
CH471096
EAW62985
EAW62986
EAW62987
ENSG00000141646
ENSP00000341551
ENSP00000381452
ENST00000342988
ENST00000342988.7
ENST00000398417
ENST00000398417.6
EntrezGene:4089
EntrezGene:SMAD4
g4885456_3p_a_at
GE59174
GE887174
GO:0000003
GO:0000122
GO:0000228
GO:0000790
GO:0000902
GO:0000977
GO:0000978
GO:0000981
GO:0000987
GO:0001085
GO:0001228
GO:0001541
GO:0001658
GO:0001666
GO:0001701
GO:0001702
GO:0001822
GO:0003148
GO:0003190
GO:0003198
GO:0003220
GO:0003251
GO:0003279
GO:0003360
GO:0003674
GO:0003677
GO:0003682
GO:0003700
GO:0003712
GO:0005515
GO:0005518
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006355
GO:0006357
GO:0006464
GO:0006810
GO:0006879
GO:0006950
GO:0007010
GO:0007165
GO:0007179
GO:0007183
GO:0007267
GO:0007283
GO:0007338
GO:0007369
GO:0007411
GO:0007492
GO:0007498
GO:0008134
GO:0008150
GO:0008219
GO:0008283
GO:0008285
GO:0008584
GO:0008585
GO:0009058
GO:0009653
GO:0009790
GO:0009952
GO:0010614
GO:0010718
GO:0010862
GO:0014033
GO:0016579
GO:0017015
GO:0022607
GO:0030154
GO:0030308
GO:0030509
GO:0030511
GO:0030513
GO:0030616
GO:0032444
GO:0032525
GO:0032909
GO:0032991
GO:0033686
GO:0034641
GO:0035019
GO:0035556
GO:0036302
GO:0040007
GO:0040011
GO:0042118
GO:0042127
GO:0042592
GO:0042733
GO:0042802
GO:0042803
GO:0043167
GO:0043199
GO:0043226
GO:0043565
GO:0044212
GO:0045892
GO:0045893
GO:0045944
GO:0046872
GO:0046881
GO:0048382
GO:0048589
GO:0048646
GO:0048663
GO:0048729
GO:0048733
GO:0048856
GO:0048859
GO:0051098
GO:0051276
GO:0051571
GO:0051797
GO:0060065
GO:0060391
GO:0060395
GO:0060412
GO:0060548
GO:0060956
GO:0061040
GO:0061614
GO:0062009
GO:0065003
GO:0070102
GO:0070207
GO:0070373
GO:0070411
GO:0070412
GO:0071141
GO:0071559
GO:0071773
GO:0072133
GO:0072134
GO:0072520
GO:0090575
GO:0098772
GO:1901522
GO:1905305
GO:2000617
HGNC:6770
HPA019154
Hs.50438.0.A1_3p_at
Hs.75862.0.S2_3p_at
ILMN_1741477
ILMN_1842785
IPR001132
IPR003619
IPR008984
IPR013019
IPR013790
IPR017855
IPR036578
K7EIJ2
K7EIU8
K7EL15
K7EL18
K7ELK2
K7ENG1
K7ENG8
K7ES96
KU178168
LRG_318
LRG_318t1
MIM:139210
MIM:174900
MIM:175050
MIM:260350
MIM:600993
NM_005359
NP_005350
PF03165
PF03166
PH_hs_0004380
SM00523
SM00524
SMAD4
SMAD4-201
SMAD4-202
TC18000998.hg
U44378
U44378_at
UPI0000053431
Participant Of
hasComponent
PAR-SMAD2/3:PAR-SMAD4 [nucleoplasm]
Other forms of this molecule
SMAD4 P356R [cytosol]
SMAD4 K428T [cytosol]
SMAD4 D351del [cytosol]
SMAD4 R361H [cytosol]
SMAD4 P356L [cytosol]
SMAD4 A406T [cytosol]
SMAD4 D351Y [cytosol]
SMAD4 D351H [cytosol]
SMAD4 [nucleoplasm]
SMAD4 [cytosol]
SMAD4 R361S [cytosol]
SMAD4 R361G [cytosol]
SMAD4 R515* [cytosol]
SMAD4 K428R [cytosol]
SMAD4 R515T [cytosol]
SMAD4 D351G [cytosol]
SMAD4 R361C [cytosol]
Inferred To
phospho-RibC-SMAD4 [nucleoplasm] (Canis familiaris)
phospho-RibC-SMAD4 [nucleoplasm] (Danio rerio)
phospho-RibC-SMAD4 [nucleoplasm] (Drosophila melanogaster)
phospho-RibC-SMAD4 [nucleoplasm] (Gallus gallus)
phospho-RibC-SMAD4 [nucleoplasm] (Mus musculus)
phospho-RibC-SMAD4 [nucleoplasm] (Rattus norvegicus)
phospho-RibC-SMAD4 [nucleoplasm] (Sus scrofa)
phospho-RibC-SMAD4 [nucleoplasm] (Xenopus tropicalis)
Modified Residues
Name
adenosine diphosphoribosyl (ADP-ribosyl) modified residue at unknown position
PsiMod Name
adenosine diphosphoribosyl (ADP-ribosyl) modified residue
PsiMod Definition
A protein modification that effectively results from forming an adduct with ADP-ribose through formation of a glycosidic bond.
Cross References
RefSeq
NP_005350.1
OpenTargets
ENSG00000141646
GeneCards
Q13485
PRO
Q13485
Orphanet
15524
PDB
1DD1
,
5UWU
,
5MF0
,
1YGS
,
1MR1
,
1U7F
,
5C4V
,
5MEZ
,
1G88
,
1U7V
,
5MEY
Interactors (33)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P84022 SMAD3
12
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-177104)
p-S423,S425-SMAD3 [cytosol]
(R-HSA-171184)
SMAD3 [cytosol]
(R-HSA-170855)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
SMAD3 [nucleoplasm]
(R-HSA-206150)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
0.975
29
UniProt:Q15796 SMAD2
15
p-S465,S467-SMAD2 P305L [cytosol]
(R-HSA-3315471)
Ub-SMAD2 [cytosol]
(R-HSA-6782774)
p-S465,S467-SMAD2 D300A [cytosol]
(R-HSA-3315064)
p-S465,S467-SMAD2 D300N [cytosol]
(R-HSA-3315066)
p-S465,S467-SMAD2 A354T [cytosol]
(R-HSA-3315474)
p-S465,S467-SMAD2 P305Q [cytosol]
(R-HSA-3315070)
p-S465,S467-SMAD2 D300V [cytosol]
(R-HSA-3315067)
SMAD2 S464* [cytosol]
(R-HSA-3304362)
p-S465,S467-SMAD2 [nucleoplasm]
(R-HSA-3009185)
p-S465,S467-SMAD2 [cytosol]
(R-HSA-3009186)
SMAD2 [cytosol]
(R-HSA-3006353)
p-T220,S465,S467-SMAD2 [nucleoplasm]
(R-HSA-3009189)
SMAD2 [nucleoplasm]
(R-HSA-3006352)
SMAD2 S467P [cytosol]
(R-HSA-3304375)
SMAD2 S464L [cytosol]
(R-HSA-3304383)
0.957
21
UniProt:Q15797 SMAD1
4
p-S463,S465-SMAD1 [cytosol]
(R-HSA-201464)
p-S463,S465-SMAD1 [nucleoplasm]
(R-HSA-201483)
SMAD1 [cytosol]
(R-HSA-201468)
Ub-SMAD1 [cytosol]
(R-HSA-6782768)
0.942
11
UniProt:P12755 SKI
1
SKI [nucleoplasm]
(R-HSA-173473)
0.91
13
UniProt:P61968 LMO4
0.817
7
UniProt:P63279 UBE2I
8
SUMO1-C93-UBE2I [cytosol]
(R-HSA-4656909)
SUMO1-K14-UBE2I [nucleoplasm]
(R-HSA-4085358)
UBE2I [nuclear envelope]
(R-HSA-4655408)
UBE2I [cytosol]
(R-HSA-4655342)
SUMO3-C93-UBE2I [nucleoplasm]
(R-HSA-3730629)
SUMO2-C93-UBE2I [nucleoplasm]
(R-HSA-3730619)
UBE2I [nucleoplasm]
(R-HSA-912481)
SUMO1-C93-UBE2I [nucleoplasm]
(R-HSA-3730617)
0.785
5
UniProt:Q9NPI6 DCP1A
1
DCP1A [cytosol]
(R-HSA-430043)
0.779
5
UniProt:Q9UPN9 TRIM33
1
TRIM33 [nucleoplasm]
(R-HSA-870522)
0.748
6
UniProt:O15198 SMAD9
3
p-S465,S467-SMAD9 [nucleoplasm]
(R-HSA-201474)
SMAD9 [cytosol]
(R-HSA-201478)
p-S465,S467-SMAD9 [cytosol]
(R-HSA-201441)
0.748
4
UniProt:O43524 FOXO3
9
p-S215 FOXO3 [cytosol]
(R-HSA-5687014)
p-S215 FOXO3 [nucleoplasm]
(R-HSA-5687010)
FOXO3 [nucleoplasm]
(R-HSA-199305)
p-T32,S253,S315-FOXO3 [nucleoplasm]
(R-HSA-199289)
p-T32,S253,S315-FOXO3 [cytosol]
(R-HSA-9614413)
Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm]
(R-HSA-9620514)
p-S43,S173,S294,S325-FOXO3 [cytosol]
(R-HSA-8870560)
p-S43,S173,S294,S325-FOXO3 [nucleoplasm]
(R-HSA-8870627)
FOXO3 [cytosol]
(R-HSA-5687032)
0.743
9
UniProt:Q8WWW0 RASF5
0.742
5
UniProt:Q9UBE8 NLK
3
p-T298-NLK [cytosol]
(R-HSA-4411398)
p-T298-NLK [nucleoplasm]
(R-HSA-4411376)
NLK [cytosol]
(R-HSA-4411330)
0.719
6
UniProt:P17676 CEBPB
3
p-T235-CEBPB [nucleoplasm]
(R-HSA-3857343)
p-T235, S321-CEBPB [nucleoplasm]
(R-HSA-3857339)
CEBPB [nucleoplasm]
(R-HSA-381378)
0.609
2
UniProt:Q92988 DLX4
0.602
5
UniProt:P70398
1
USP9X [cytosol]
(R-MMU-870499)
0.602
4
UniProt:P24468 NR2F2
1
NR2F2 [nucleoplasm]
(R-HSA-1183002)
0.591
4
UniProt:Q01844 EWS
0.553
2
UniProt:O75925 PIAS1
1
PIAS1 [nucleoplasm]
(R-HSA-877307)
0.553
2
UniProt:Q6VMQ6 ATF7IP
1
ATF7IP [nucleoplasm]
(R-HSA-3301918)
0.553
2
UniProt:P12757 SKIL
1
SKIL [nucleoplasm]
(R-HSA-2186596)
0.547
3
UniProt:Q13485 SMAD4
18
SMAD4 K428T [cytosol]
(R-HSA-3311004)
SMAD4 P356R [cytosol]
(R-HSA-3310988)
SMAD4 D351del [cytosol]
(R-HSA-3310974)
SMAD4 R361H [cytosol]
(R-HSA-3310984)
SMAD4 P356L [cytosol]
(R-HSA-3310987)
SMAD4 A406T [cytosol]
(R-HSA-3311003)
SMAD4 D351Y [cytosol]
(R-HSA-3310970)
SMAD4 D351H [cytosol]
(R-HSA-3310965)
SMAD4 [nucleoplasm]
(R-HSA-177103)
SMAD4 [cytosol]
(R-HSA-170862)
RibC-SMAD4 [nucleoplasm]
(R-HSA-2187323)
SMAD4 R361S [cytosol]
(R-HSA-3310994)
SMAD4 R361G [cytosol]
(R-HSA-3310993)
SMAD4 R515* [cytosol]
(R-HSA-3311012)
SMAD4 K428R [cytosol]
(R-HSA-3311001)
SMAD4 R515T [cytosol]
(R-HSA-3311008)
SMAD4 D351G [cytosol]
(R-HSA-3310967)
SMAD4 R361C [cytosol]
(R-HSA-3310983)
0.547
3
UniProt:SMAD7 ENSG00000101665
0.527
3
UniProt:Q9UI36 DACH1
0.524
3
UniProt:P98177 FOXO4
8
Ac-K-FOXO4 [nucleoplasm]
(R-HSA-9617761)
PolyUb-FOXO4 [nucleoplasm]
(R-HSA-6782501)
EP300-S-S-FOXO4 [nucleoplasm]
(R-HSA-9617681)
CREBBP-S-S-FOXO4 [nucleoplasm]
(R-HSA-9617679)
SOH-C481-FOXO4 [nucleoplasm]
(R-HSA-9617655)
p-T32,S197,S262-FOXO4 [cytosol]
(R-HSA-9614415)
p-T32,S197,S262-FOXO4 [nucleoplasm]
(R-HSA-199314)
FOXO4 [nucleoplasm]
(R-HSA-5690183)
0.524
2
UniProt:P23769 GATA2
1
GATA2 [nucleoplasm]
(R-HSA-996735)
0.508
2
IntAct:EBI-11165649 P21
0.499
2
UniProt:P70056 FOXH1
0.499
2
UniProt:Q15915 ZIC1
0.488
2
UniProt:O15198-2 SMAD9
0.488
2
UniProt:P43268-3 ETV4
0.488
2
UniProt:Q8NI38 IKBD
0.488
2
UniProt:Q96F07 CYFIP2
1
CYFIP2 [cytosol]
(R-HSA-1671642)
0.488
2
UniProt:Q08117-2 TLE5
0.488
2
© 2019
Reactome