PMEPA1 sequesters unphosphorylated SMAD2/3

Stable Identifier
R-HSA-2187358
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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PMEPA1 sequesters unphosphorylated SMAD2/3
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PMEPA1 binds unphosphorylated SMAD2 and SMAD3 and prevents their phosphorylation in response to TGF-beta stimulation (Watanabe et al. 2010).
Literature References
PubMed ID Title Journal Year
20129061 TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling

Yang, W, Shibuya, H, Itoh, S, Shi, L, Goto, T, Satoh, K, Kato, M, Tanaka, A, Inamitsu, M, Watanabe, Y, Wiercinska, E, ten Dijke, P, Ohnishi, E, Mommaas, AM, Nakano, N, Itoh, F

Mol Cell 2010
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Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Created
Orlic-Milacic, M  (2012-04-09)
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