STUB1 (CHIP) ubiquitinates SMAD3

Stable Identifier
R-HSA-2187368
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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STUB1 (CHIP) ubiquitinates SMAD3
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STUB1 (CHIP) ubiquitinates SMAD3 in the absence of TGF-beta stimulation (Li et al. 2004, Xin et al. 2005).
Literature References
PubMed ID Title Journal Year
14701756 CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription

Zhang, S, Fu, XY, Xin, H, Li, L, Zhang, X, Chang, Z, Chen, Y, Xu, X, Huang, M

Mol Cell Biol 2004
15781469 CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation

Fu, XY, Xin, H, Li, L, Chang, Z, Rong, Y, Xu, X, Ning, H, Shang, Y, Wang, Y

J Biol Chem 2005
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Catalyst Activity

ubiquitin-protein transferase activity of SMAD3:STUB1 [cytosol]

Physical Entity
SMAD3:STUB1 [cytosol] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
STUB1 (CHIP) ubiquitinates SMAD3 (Bos taurus)
STUB1 (CHIP) ubiquitinates SMAD3 (Caenorhabditis elegans)
STUB1 (CHIP) ubiquitinates SMAD3 (Canis familiaris)
STUB1 (CHIP) ubiquitinates SMAD3 (Drosophila melanogaster)
STUB1 (CHIP) ubiquitinates SMAD3 (Gallus gallus)
STUB1 (CHIP) ubiquitinates SMAD3 (Mus musculus)
STUB1 (CHIP) ubiquitinates SMAD3 (Rattus norvegicus)
STUB1 (CHIP) ubiquitinates SMAD3 (Sus scrofa)
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Created
Orlic-Milacic, M  (2012-04-09)
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