Reactome | CALR [extracellular region]

CALR [extracellular region]

Stable Identifier

R-HSA-2197641

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Calreticulin, CALR_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P27797 CALR

Gene Names

CALR, CRTC

Chain

signal peptide:1-17, chain:18-417

Reference Genes

BioGPS Gene:811 CALR

COSMIC (genes):CALR CALR

CTD Gene:811 CALR

dbSNP Gene:811 CALR

ENSEMBL:ENSG00000179218 CALR

HGNC:1455 CALR

KEGG Gene (Homo sapiens):811 CALR

Monarch:811 CALR

NCBI Gene:811 CALR

OMIM:109091 CALR

Reference Transcript

RefSeq:NM_004343.3 CALR

Other Identifiers

0003450132

11715374_a_at

11715375_x_at

16858774

1752_at

200935_at

212953_x_at

214315_x_at

32543_at

3822050

3822051

3822053

3822054

3822055

3822056

3822057

3822058

3822059

3822060

3822065

3822066

3822067

3822068

3822069

3822070

3822071

3822072

3822073

8026106

811

A_14_P107778

A_23_P67288

A_33_P3292854

GE79860

GO:0000003

GO:0000122

GO:0000902

GO:0001669

GO:0001849

GO:0002376

GO:0002474

GO:0002479

GO:0002502

GO:0003674

GO:0003677

GO:0003723

GO:0003729

GO:0005178

GO:0005506

GO:0005509

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005635

GO:0005737

GO:0005783

GO:0005788

GO:0005789

GO:0005790

GO:0005794

GO:0005829

GO:0005844

GO:0005886

GO:0005925

GO:0006355

GO:0006412

GO:0006457

GO:0006611

GO:0006810

GO:0006874

GO:0006898

GO:0006913

GO:0006950

GO:0007010

GO:0007049

GO:0007155

GO:0007165

GO:0007283

GO:0007568

GO:0008134

GO:0008150

GO:0008219

GO:0008270

GO:0008283

GO:0008284

GO:0009058

GO:0009897

GO:0009986

GO:0010033

GO:0010595

GO:0010628

GO:0015031

GO:0016020

GO:0016192

GO:0016529

GO:0017148

GO:0019899

GO:0022417

GO:0022607

GO:0030154

GO:0030246

GO:0030670

GO:0030866

GO:0030968

GO:0031012

GO:0031410

GO:0031625

GO:0032355

GO:0032991

GO:0033018

GO:0033116

GO:0033144

GO:0033574

GO:0034504

GO:0034641

GO:0034975

GO:0036500

GO:0040011

GO:0040020

GO:0042277

GO:0042493

GO:0042562

GO:0042592

GO:0042824

GO:0042921

GO:0042981

GO:0043167

GO:0043226

GO:0043231

GO:0044183

GO:0044322

GO:0045665

GO:0045787

GO:0045892

GO:0046872

GO:0048387

GO:0048471

GO:0048856

GO:0048870

GO:0050681

GO:0050766

GO:0050821

GO:0051082

GO:0051087

GO:0051208

GO:0051604

GO:0055007

GO:0061024

GO:0062023

GO:0065003

GO:0070062

GO:0071157

GO:0071285

GO:0071310

GO:0071556

GO:0071682

GO:0090398

GO:1900026

GO:1901164

GO:1901224

GO:1990668

GO:2000510

Hs.16488.2.A1_3p_x_at

Hs.16488.3.A1_3p_x_at

ILMN_1736256

M84739_at

PH_hs_0017137

TC19000232.hg

g5921996_3p_a_at

Participant Of

hasMember

Other forms of this molecule

CALR [endoplasmic reticulum lumen]

CALR [integral component of lumenal side of endoplasmic reticulum membrane]

CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]

CALR [phagocytic vesicle membrane]

CALR [endocytic vesicle lumen]

Inferred To

CALR [extracellular region] (Gallus gallus)

CALR [extracellular region] (Sus scrofa)

Calr [extracellular region] (Mus musculus)

Calr [extracellular region] (Rattus norvegicus)

calr [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_004334.1

Target Pathogen

5b354852be737e166372e7b4

OpenTargets

ENSG00000179218

HPA

ENSG00000179218-CALR

GeneCards

P27797

Ensembl

ENSG00000179218, ENST00000316448, ENSP00000320866

PRO

P27797

Orphanet

22642

HMDB Protein

HMDBP07533

PDB

3POW, 3POS, 5V90, 6ENY, 5LK5, 3DOW, 2CLR

Interactors (87)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.75	5
UniProt:O95166 GABARAP	3	GABARAP(1-117) [cytosol] (R-HSA-5682696) GABARAP [cytosol] (R-HSA-975521) GABARAP [autophagosome membrane] (R-HSA-5683634)	0.71	4
UniProt:P48039 MTNR1A	1	MTNR1A [plasma membrane] (R-HSA-419316)	0.659	3
UniProt:Q12824 SMARCB1	1	SMARCB1 [nucleoplasm] (R-HSA-389261)	0.613	5
UniProt:P30101 PDIA3	3	PDIA3 [recycling endosome membrane] (R-HSA-8863849) PDIA3 [phagocytic vesicle] (R-HSA-1236870) PDIA3 [endoplasmic reticulum lumen] (R-HSA-901028)	0.589	2
UniProt:Q96EF9 ZHX1R			0.556	3
UniProt:P09471 GNAO1	1	GNAO1 [plasma membrane] (R-HSA-2997536)	0.556	3
UniProt:Q68CL5-3 TPGS2			0.556	3
UniProt:O75175 CNOT3	1	CNOT3 [cytosol] (R-HSA-429872)	0.556	3
UniProt:Q9NX07 TSAP1			0.556	3
IntAct:EBI-25833913 CCSB			0.556	3
UniProt:Q7Z698 SPRED2	2	SPRED2 [plasma membrane] (R-HSA-5658229) SPRED2 [cytosol] (R-HSA-5654211)	0.556	3
UniProt:Q3SY56 SP6			0.556	3
IntAct:EBI-25831691 CCSB			0.556	3
UniProt:Q96E17 RAB3C	2	RAB3C [cytosol] (R-HSA-8873684) GGC-RAB3C [cytosol] (R-HSA-8874012)	0.556	3
UniProt:Q9NVM1 EVA1B			0.556	3
UniProt:O94983-5 CAMTA2			0.556	3
UniProt:Q9HC98-4 NEK6			0.556	3
UniProt:P36382 GJA5	1	GJA5 [endoplasmic reticulum membrane] (R-HSA-190648)	0.556	3
UniProt:Q7Z780 Q7Z780			0.556	3
UniProt:Q96GK7 FAH2A			0.556	3
UniProt:Q02978 SLC25A11	1	SLC25A11 [mitochondrial inner membrane] (R-HSA-198451)	0.556	3
UniProt:Q8TAB5 CA216			0.556	3
UniProt:P49184 DNASE1L1	2	DNASE1L1 [extracellular region] (R-HSA-6806320) DNASE1L1 [specific granule lumen] (R-HSA-6799554)	0.556	3
UniProt:Q9H2S6-2 TNMD			0.556	3
UniProt:Q96L03 SPT17			0.556	3
UniProt:F6Y2X3 F6Y2X3			0.556	3
UniProt:Q96I25 RBM17	1	RBM17 [nucleoplasm] (R-HSA-8865891)	0.556	3
UniProt:A2RUH7 MBPHL			0.556	3
UniProt:Q8N1W1-4 ARHGEF28			0.556	3
UniProt:Q9BT49 THAP7			0.556	3
UniProt:Q9Y617 PSAT1	1	PXLP-K200-PSAT1 [cytosol] (R-HSA-977330)	0.556	3
UniProt:Q9BQ29 Q9BQ29			0.556	3
UniProt:O15499 GSC2			0.556	3
UniProt:Q8TB02 Q8TB02			0.556	3
UniProt:P43356 MAGA2			0.556	3
UniProt:Q96JJ7-2 Q96JJ72			0.556	3
UniProt:P14060 HSD3B1	1	HSD3B1 [endoplasmic reticulum membrane] (R-HSA-192072)	0.556	3
UniProt:P79483 HLA-DRB3	9	HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [clathrin-coated endocytic vesicle membrane] (R-HSA-2130515) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [transport vesicle membrane] (R-HSA-2130559) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [endocytic vesicle membrane] (R-HSA-2130377) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-2130432) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-2130513) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [Golgi membrane] (R-HSA-2214381) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [trans-Golgi network membrane] (R-HSA-2130452) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lysosomal membrane] (R-HSA-2130676) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [plasma membrane] (R-HSA-197577)	0.556	3
UniProt:Q6P4D5-2 FAM122C			0.556	3
UniProt:Q6P5S2 LEG1H			0.556	3
UniProt:Q7Z434 MAVS	2	K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463) MAVS [mitochondrial outer membrane] (R-HSA-913730)	0.556	3
IntAct:EBI-25834143 CCSB			0.556	3
UniProt:O75317 USP12	1	USP12 [nucleoplasm] (R-HSA-5696907)	0.556	3
IntAct:EBI-25833532 RZPDO839F06154			0.556	3
UniProt:O75874 IDH1	10	IDH1 R132L mutant [cytosol] (R-HSA-880000) IDH1 R132H mutant [cytosol] (R-HSA-880015) IDH1 R132S mutant [cytosol] (R-HSA-880048) IDH1 R132C mutant [cytosol] (R-HSA-880031) IDH1 [cytosol] (R-HSA-389549) IDH1 [peroxisomal matrix] (R-HSA-389546) IDH1 [ficolin-1-rich granule lumen] (R-HSA-6800977) IDH1 [secretory granule lumen] (R-HSA-6800980) IDH1 [extracellular region] (R-HSA-6806433) IDH1 [tertiary granule lumen] (R-HSA-6800163)	0.556	3
UniProt:Q13636 RAB31	5	GGC-RAB31 [cytosol] (R-HSA-8873974) GGC-RAB31 [early endosome membrane] (R-HSA-8877278) RAB31 [cytosol] (R-HSA-8873690) RAB31 [plasma membrane] (R-HSA-6804813) RAB31 [secretory granule membrane] (R-HSA-6804797)	0.556	3
UniProt:Q8NBT0 POC1A			0.556	3
UniProt:Q96EQ0 SGTB			0.556	3
UniProt:Q96EY8 MMAB	4	MMAB R191W [mitochondrial matrix] (R-HSA-3322112) MMAB E193K [mitochondrial matrix] (R-HSA-3322150) MMAB R186W [mitochondrial matrix] (R-HSA-3322128) MMAB [mitochondrial matrix] (R-HSA-2980970)	0.556	3
UniProt:P49746 THBS3	1	THBS3 [extracellular region] (R-HSA-66522)	0.556	3
UniProt:P48775 TDO2	1	TDO2 [cytosol] (R-HSA-71184)	0.556	3
UniProt:A0JP07 A0JP07			0.556	3
UniProt:P43686 PSMC4	2	PSMC4 [cytosol] (R-HSA-68777) PSMC4 [nucleoplasm] (R-HSA-174315)	0.556	3
UniProt:O00214-2 LGALS8			0.556	3
UniProt:Q9Y3Y4 PYGO1	1	PYGO1 [nucleoplasm] (R-HSA-201705)	0.556	3
UniProt:Q96QH2 PRAM			0.556	3
UniProt:O14829 PPEF1	1	PPEF1 [cytosol] (R-HSA-2632517)	0.556	3
UniProt:Q99944 EGFL8			0.556	3
UniProt:Q8NCF5-2 NFATC2IP			0.556	3
UniProt:P50749 RASF2			0.556	3
UniProt:Q8NCR3 MFI			0.556	3
UniProt:P09382 LGALS1	2	LGALS1 [endoplasmic reticulum lumen] (R-HSA-8956711) p-LGALS1 [endoplasmic reticulum lumen] (R-HSA-8957003)	0.556	3
IntAct:EBI-25833762 CCSB			0.556	3
IntAct:EBI-25833683 CCSB			0.556	3
UniProt:Q8IY82 DRC7			0.556	3
UniProt:Q13200 PSMD2	5	PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435) PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [cytosol] (R-HSA-68796)	0.556	3
UniProt:Q9NPC7 MYNN			0.556	3
UniProt:Q8N323 NXPE1			0.556	3
UniProt:Q6UXH1-2 CRELD2			0.556	3
UniProt:Q7Z6Z7-2 HUWE1			0.556	3
UniProt:P07437 TUBB	3	TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [cytosol] (R-HSA-9020816) TUBB [extracellular region] (R-HSA-380317)	0.556	3
UniProt:Q9ULR0 ISY1	1	ISY1 [nucleoplasm] (R-HSA-6781963)	0.556	3
UniProt:Q8N2W9 PIAS4	2	SUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415) PIAS4 [nucleoplasm] (R-HSA-2993789)	0.556	3
UniProt:P52756 RBM5	1	RBM5 [nucleoplasm] (R-HSA-72049)	0.556	3
UniProt:Q10981 FUT2	1	FUT2 [Golgi membrane] (R-HSA-2980904)	0.556	3
UniProt:P16422 EPCAM	1	EPCAM [plasma membrane] (R-HSA-375068)	0.556	3
UniProt:Q53T94 TAF1B	2	Ac-TAF1B [nucleoplasm] (R-HSA-5138530) TAF1B [nucleoplasm] (R-HSA-73691)	0.556	3
UniProt:Q9ULW0 TPX2	2	TPX2 [cytosol] (R-HSA-8853407) TPX2 [nucleoplasm] (R-HSA-2564700)	0.556	3
UniProt:P26715 KLRC1	1	KLRC1 [plasma membrane] (R-HSA-3006545)	0.556	3
UniProt:P61224 RAP1B	2	RAP1B [plasma membrane] (R-HSA-377590) RAP1B [azurophil granule membrane] (R-HSA-6804972)	0.556	3
UniProt:Q96P20 NLRP3	2	NLRP3 [cytosol] (R-HSA-561189) K63polyUb-NLRP3 [cytosol] (R-HSA-6783288)	0.556	3
UniProt:Q96GX1 TCTN2	1	TCTN2 [ciliary membrane] (R-HSA-5626661)	0.508	2
UniProt:P04792 HSPB1	3	p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) HSPB1 [cytosol] (R-HSA-450563) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.508	2
UniProt:Q03518 TAP1	3	TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863953) TAP1 [phagocytic vesicle membrane] (R-HSA-1236845) TAP1 [endoplasmic reticulum membrane] (R-HSA-947474)	0.499	2
UniProt:P29991-PRO_0000037946			0.488	2
UniProt:P04578 env	7	Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Surface protein gp120 (P04578) [cytosol] (R-HIV-189269) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211)	0.462	4

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