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CALR [extracellular region]
Stable Identifier
R-HSA-2197641
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Calreticulin, CALR_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Binding and Uptake of Ligands by Scavenger Receptors (Homo sapiens)
Scavenging by Class A Receptors (Homo sapiens)
MSR1 (SCARA1, SR-A) binds ligands (Homo sapiens)
Ligands of MSR1 [extracellular region] (Homo sapiens)
CALR [extracellular region] (Homo sapiens)
MSR1:Ligand [plasma membrane] (Homo sapiens)
Ligands of MSR1 [extracellular region] (Homo sapiens)
CALR [extracellular region] (Homo sapiens)
MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Homo sapiens)
MSR1:Ligand [plasma membrane] (Homo sapiens)
Ligands of MSR1 [extracellular region] (Homo sapiens)
CALR [extracellular region] (Homo sapiens)
Scavenging by Class F Receptors (Homo sapiens)
SCARF1 (SREC-I) binds ligands (Homo sapiens)
Ligands of SCARF1 [extracellular region] (Homo sapiens)
CALR [extracellular region] (Homo sapiens)
SCARF1:Ligand [plasma membrane] (Homo sapiens)
Ligands of SCARF1 [extracellular region] (Homo sapiens)
CALR [extracellular region] (Homo sapiens)
SCARF1:ligand is endocytosed (Homo sapiens)
SCARF1:Ligand [plasma membrane] (Homo sapiens)
Ligands of SCARF1 [extracellular region] (Homo sapiens)
CALR [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P27797 CALR
Gene Names
CALR, CRTC
Chain
signal peptide:1-17, chain:18-417
Reference Genes
BioGPS Gene:811 CALR
COSMIC (genes):CALR CALR
CTD Gene:811 CALR
dbSNP Gene:811 CALR
ENSEMBL:ENSG00000179218 CALR
HGNC:1455 CALR
KEGG Gene (Homo sapiens):811 CALR
Monarch:811 CALR
NCBI Gene:811 CALR
OMIM:109091 CALR
Reference Transcript
RefSeq:NM_004343.3 CALR
Other Identifiers
0003450132
11715374_a_at
11715375_x_at
16858774
1752_at
200935_at
212953_x_at
214315_x_at
32543_at
3822050
3822051
3822053
3822054
3822055
3822056
3822057
3822058
3822059
3822060
3822065
3822066
3822067
3822068
3822069
3822070
3822071
3822072
3822073
8026106
811
A_14_P107778
A_23_P67288
A_33_P3292854
GE79860
GO:0000003
GO:0000122
GO:0000902
GO:0001669
GO:0001849
GO:0002376
GO:0002474
GO:0002479
GO:0002502
GO:0003674
GO:0003677
GO:0003723
GO:0003729
GO:0005178
GO:0005506
GO:0005509
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005635
GO:0005737
GO:0005783
GO:0005788
GO:0005789
GO:0005790
GO:0005794
GO:0005829
GO:0005844
GO:0005886
GO:0005925
GO:0006355
GO:0006412
GO:0006457
GO:0006611
GO:0006810
GO:0006874
GO:0006898
GO:0006913
GO:0006950
GO:0007010
GO:0007049
GO:0007155
GO:0007165
GO:0007283
GO:0007568
GO:0008134
GO:0008150
GO:0008219
GO:0008270
GO:0008283
GO:0008284
GO:0009058
GO:0009897
GO:0009986
GO:0010033
GO:0010595
GO:0010628
GO:0015031
GO:0016020
GO:0016192
GO:0016529
GO:0017148
GO:0019899
GO:0022417
GO:0022607
GO:0030133
GO:0030154
GO:0030246
GO:0030670
GO:0030866
GO:0030968
GO:0031012
GO:0031410
GO:0031625
GO:0032355
GO:0032991
GO:0033018
GO:0033116
GO:0033144
GO:0033574
GO:0034504
GO:0034641
GO:0034975
GO:0036500
GO:0040011
GO:0040020
GO:0042277
GO:0042493
GO:0042562
GO:0042592
GO:0042824
GO:0042921
GO:0042981
GO:0043167
GO:0043226
GO:0043231
GO:0044183
GO:0044322
GO:0045665
GO:0045787
GO:0045892
GO:0046872
GO:0048387
GO:0048471
GO:0048856
GO:0048870
GO:0050681
GO:0050766
GO:0050821
GO:0051082
GO:0051087
GO:0051208
GO:0051604
GO:0055007
GO:0060473
GO:0061024
GO:0062023
GO:0065003
GO:0070062
GO:0071157
GO:0071285
GO:0071310
GO:0071556
GO:0071682
GO:0090398
GO:1900026
GO:1901164
GO:1901224
GO:1990668
GO:2000510
HMNXSV003044478
Hs.16488.2.A1_3p_x_at
Hs.16488.3.A1_3p_x_at
ILMN_1736256
M84739_at
PH_hs_0017137
TC19000232.hg
g5921996_3p_a_at
Participates
as a member of
Ligands of MSR1 [extracellular region] (Homo sapiens)
Ligands of SCARF1 [extracellular region] (Homo sapiens)
Other forms of this molecule
CALR [endoplasmic reticulum lumen]
CALR [integral component of lumenal side of endoplasmic reticulum membrane]
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
CALR [phagocytic vesicle membrane]
CALR [endocytic vesicle lumen]
Inferred To
CALR [extracellular region]
(Gallus gallus)
CALR [extracellular region]
(Sus scrofa)
CALR [extracellular region]
(Xenopus tropicalis)
Calr [extracellular region]
(Mus musculus)
Calr [extracellular region]
(Rattus norvegicus)
calr [extracellular region]
(Danio rerio)
Cross References
RefSeq
NP_004334.1
OpenTargets
ENSG00000179218
GeneCards
P27797
HPA
ENSG00000179218-CALR
Ensembl
ENSP00000320866
,
ENST00000316448
,
ENSG00000179218
PRO
P27797
Pharos - Targets
P27797
GlyGen
P27797
Orphanet
22642
PDB
3POS
,
5LK5
,
3DOW
,
5V90
,
3POW
,
6ENY
,
2CLR
HMDB Protein
HMDBP07533
Interactors (87)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05067 APP
20
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.737
5
UniProt:O95166 GABARAP
3
GABARAP(1-117) [cytosol]
(R-HSA-5682696)
GABARAP [cytosol]
(R-HSA-975521)
GABARAP [autophagosome membrane]
(R-HSA-5683634)
0.71
4
UniProt:P48039 MTNR1A
1
MTNR1A [plasma membrane]
(R-HSA-419316)
0.659
3
UniProt:Q12824 SMARCB1
1
SMARCB1 [nucleoplasm]
(R-HSA-389261)
0.594
5
UniProt:P30101 PDIA3
3
PDIA3 [recycling endosome membrane]
(R-HSA-8863849)
PDIA3 [phagocytic vesicle]
(R-HSA-1236870)
PDIA3 [endoplasmic reticulum lumen]
(R-HSA-901028)
0.589
2
UniProt:Q96EF9 ZHX1R
0.556
3
UniProt:P09471 GNAO1
1
GNAO1 [plasma membrane]
(R-HSA-2997536)
0.556
3
UniProt:Q68CL5-3 TPGS2
0.556
3
UniProt:O75175 CNOT3
1
CNOT3 [cytosol]
(R-HSA-429872)
0.556
3
UniProt:Q9NX07 TSAP1
0.556
3
IntAct:EBI-25833913 CCSB
0.556
3
UniProt:Q7Z698 SPRED2
2
SPRED2 [plasma membrane]
(R-HSA-5658229)
SPRED2 [cytosol]
(R-HSA-5654211)
0.556
3
UniProt:Q3SY56 SP6
0.556
3
IntAct:EBI-25831691 CCSB
0.556
3
UniProt:Q96E17 RAB3C
2
RAB3C [cytosol]
(R-HSA-8873684)
GGC-RAB3C [cytosol]
(R-HSA-8874012)
0.556
3
UniProt:Q9NVM1 EVA1B
0.556
3
UniProt:O94983-5 CAMTA2
0.556
3
UniProt:Q9HC98-4 NEK6
0.556
3
UniProt:P36382 GJA5
1
GJA5 [endoplasmic reticulum membrane]
(R-HSA-190648)
0.556
3
UniProt:Q7Z780 Q7Z780
0.556
3
UniProt:Q96GK7 FAH2A
0.556
3
UniProt:Q02978 SLC25A11
1
SLC25A11 [mitochondrial inner membrane]
(R-HSA-198451)
0.556
3
UniProt:Q8TAB5 CA216
0.556
3
UniProt:P49184 DNASE1L1
2
DNASE1L1 [specific granule lumen]
(R-HSA-6799554)
DNASE1L1 [extracellular region]
(R-HSA-6806320)
0.556
3
UniProt:Q9H2S6-2 TNMD
0.556
3
UniProt:Q96L03 SPT17
0.556
3
UniProt:F6Y2X3 F6Y2X3
0.556
3
UniProt:Q96I25 RBM17
1
RBM17 [nucleoplasm]
(R-HSA-8865891)
0.556
3
UniProt:A2RUH7 MBPHL
0.556
3
UniProt:Q8N1W1-4 ARHGEF28
0.556
3
UniProt:Q9BT49 THAP7
0.556
3
UniProt:Q9Y617 PSAT1
1
PXLP-K200-PSAT1 [cytosol]
(R-HSA-977330)
0.556
3
UniProt:Q9BQ29 Q9BQ29
0.556
3
UniProt:O15499 GSC2
0.556
3
UniProt:Q8TB02 Q8TB02
0.556
3
UniProt:P43356 MAGA2
0.556
3
UniProt:Q8N2W9 PIAS4
2
SUMO1-K35-PIAS4 [nucleoplasm]
(R-HSA-3968415)
PIAS4 [nucleoplasm]
(R-HSA-2993789)
0.556
3
UniProt:Q96JJ7-2 Q96JJ72
0.556
3
UniProt:P14060 HSD3B1
1
HSD3B1 [endoplasmic reticulum membrane]
(R-HSA-192072)
0.556
3
UniProt:P79483 HLA-DRB3
9
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [ER to Golgi transport vesicle membrane]
(R-HSA-2130432)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-2130513)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [Golgi membrane]
(R-HSA-2214381)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [trans-Golgi network membrane]
(R-HSA-2130452)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [transport vesicle membrane]
(R-HSA-2130559)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130515)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [endocytic vesicle membrane]
(R-HSA-2130377)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lysosomal membrane]
(R-HSA-2130676)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [plasma membrane]
(R-HSA-197577)
0.556
3
UniProt:P26715 KLRC1
1
KLRC1 [plasma membrane]
(R-HSA-3006545)
0.556
3
UniProt:Q6P4D5-2 PABIR3
0.556
3
UniProt:Q6P5S2 LEG1H
0.556
3
UniProt:P16422 EPCAM
1
EPCAM [plasma membrane]
(R-HSA-375068)
0.556
3
IntAct:EBI-25834143 CCSB
0.556
3
UniProt:O75317 USP12
1
USP12 [nucleoplasm]
(R-HSA-5696907)
0.556
3
IntAct:EBI-25833532 RZPDO839F06154
0.556
3
UniProt:O75874 IDH1
10
IDH1 R132L mutant [cytosol]
(R-HSA-880000)
IDH1 R132H mutant [cytosol]
(R-HSA-880015)
IDH1 R132S mutant [cytosol]
(R-HSA-880048)
IDH1 R132C mutant [cytosol]
(R-HSA-880031)
IDH1 [ficolin-1-rich granule lumen]
(R-HSA-6800977)
IDH1 [secretory granule lumen]
(R-HSA-6800980)
IDH1 [extracellular region]
(R-HSA-6806433)
IDH1 [tertiary granule lumen]
(R-HSA-6800163)
IDH1 [peroxisomal matrix]
(R-HSA-389546)
IDH1 [cytosol]
(R-HSA-389549)
0.556
3
UniProt:Q8NBT0 POC1A
0.556
3
UniProt:P52756 RBM5
1
RBM5 [nucleoplasm]
(R-HSA-72049)
0.556
3
UniProt:Q13636 RAB31
5
GGC-RAB31 [cytosol]
(R-HSA-8873974)
GGC-RAB31 [early endosome membrane]
(R-HSA-8877278)
RAB31 [cytosol]
(R-HSA-8873690)
RAB31 [plasma membrane]
(R-HSA-6804813)
RAB31 [secretory granule membrane]
(R-HSA-6804797)
0.556
3
UniProt:Q96EQ0 SGTB
0.556
3
UniProt:Q96EY8 MMAB
4
MMAB R191W [mitochondrial matrix]
(R-HSA-3322112)
MMAB E193K [mitochondrial matrix]
(R-HSA-3322150)
MMAB R186W [mitochondrial matrix]
(R-HSA-3322128)
MMAB [mitochondrial matrix]
(R-HSA-2980970)
0.556
3
UniProt:P49746 THBS3
1
THBS3 [extracellular region]
(R-HSA-66522)
0.556
3
UniProt:P48775 TDO2
1
TDO2 [cytosol]
(R-HSA-71184)
0.556
3
UniProt:A0JP07 A0JP07
0.556
3
UniProt:P43686 PSMC4
2
PSMC4 [cytosol]
(R-HSA-68777)
PSMC4 [nucleoplasm]
(R-HSA-174315)
0.556
3
UniProt:O00214-2 LGALS8
0.556
3
UniProt:Q9ULR0 ISY1
1
ISY1 [nucleoplasm]
(R-HSA-6781963)
0.556
3
UniProt:Q9Y3Y4 PYGO1
1
PYGO1 [nucleoplasm]
(R-HSA-201705)
0.556
3
UniProt:Q96QH2 PRAM
0.556
3
UniProt:O14829 PPEF1
1
PPEF1 [cytosol]
(R-HSA-2632517)
0.556
3
UniProt:Q99944 EGFL8
0.556
3
UniProt:P61224 RAP1B
2
RAP1B [plasma membrane]
(R-HSA-377590)
RAP1B [azurophil granule membrane]
(R-HSA-6804972)
0.556
3
UniProt:Q8NCF5-2 NFATC2IP
0.556
3
UniProt:P50749 RASF2
0.556
3
UniProt:Q8NCR3 MFI
0.556
3
UniProt:P09382 LGALS1
2
LGALS1 [endoplasmic reticulum lumen]
(R-HSA-8956711)
p-LGALS1 [endoplasmic reticulum lumen]
(R-HSA-8957003)
0.556
3
IntAct:EBI-25833762 CCSB
0.556
3
IntAct:EBI-25833683 CCSB
0.556
3
UniProt:Q8IY82 DRC7
0.556
3
UniProt:Q13200 PSMD2
5
PSMD2 [extracellular region]
(R-HSA-6806479)
PSMD2 [ficolin-1-rich granule lumen]
(R-HSA-6800435)
PSMD2 [secretory granule lumen]
(R-HSA-6800919)
PSMD2 [nucleoplasm]
(R-HSA-174311)
PSMD2 [cytosol]
(R-HSA-68796)
0.556
3
UniProt:Q9NPC7 MYNN
0.556
3
UniProt:Q8N323 NXPE1
0.556
3
UniProt:Q6UXH1-2 CRELD2
0.556
3
UniProt:Q7Z6Z7-2 HUWE1
0.556
3
UniProt:Q10981 FUT2
1
FUT2 [Golgi membrane]
(R-HSA-2980904)
0.556
3
UniProt:Q53T94 TAF1B
2
Ac-TAF1B [nucleoplasm]
(R-HSA-5138530)
TAF1B [nucleoplasm]
(R-HSA-73691)
0.556
3
UniProt:P07437 TUBB
3
TUBB [azurophil granule lumen]
(R-HSA-6799370)
TUBB [cytosol]
(R-HSA-9020816)
TUBB [extracellular region]
(R-HSA-380317)
0.556
3
UniProt:Q7Z434 MAVS
2
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
0.556
3
UniProt:Q9ULW0 TPX2
2
TPX2 [nucleoplasm]
(R-HSA-2564700)
TPX2 [cytosol]
(R-HSA-8853407)
0.556
3
UniProt:Q96P20 NLRP3
2
NLRP3 [cytosol]
(R-HSA-561189)
K63polyUb-NLRP3 [cytosol]
(R-HSA-6783288)
0.556
3
UniProt:Q96GX1 TCTN2
1
TCTN2 [ciliary membrane]
(R-HSA-5626661)
0.508
2
UniProt:P04792 HSPB1
3
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
HSPB1 [cytosol]
(R-HSA-450563)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.508
2
UniProt:Q03518 TAP1
3
TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863953)
TAP1 [phagocytic vesicle membrane]
(R-HSA-1236845)
TAP1 [endoplasmic reticulum membrane]
(R-HSA-947474)
0.499
2
UniProt:P29991-PRO_0000037946
0.488
2
UniProt:P04578 env
7
Transmembrane protein gp41 (P04578) [cytosol]
(R-HIV-189359)
Surface protein gp120 (P04578) [cytosol]
(R-HIV-189269)
Glycosylated Envelope glycoprotein gp160 [Golgi membrane]
(R-HIV-3149443)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane]
(R-HIV-189343)
Transmembrane protein gp41 [viral envelope]
(R-HIV-171195)
Surface protein gp120 [viral envelope]
(R-HIV-171211)
ENV [viral envelope]
(R-HIV-173439)
0.462
4
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