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NCKIPSD [cytosol]
Stable Identifier
R-HSA-2197671
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
WISH, NCK-interacting protein with SH3 domain, SPN90_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
Attachment of preexisting mother filament and initiation of branching (Homo sapiens)
Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
SH3 domain proteins [cytosol] (Homo sapiens)
NCKIPSD [cytosol] (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
SH3 domain proteins [cytosol] (Homo sapiens)
NCKIPSD [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
SH3 domain proteins [cytosol] (Homo sapiens)
NCKIPSD [cytosol] (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
SH3 domain proteins [cytosol] (Homo sapiens)
NCKIPSD [cytosol] (Homo sapiens)
Src family kinases (SFKs) phosphorylate WASP/N-WASP (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
SH3 domain proteins [cytosol] (Homo sapiens)
NCKIPSD [cytosol] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
SH3 domain proteins [cytosol] (Homo sapiens)
NCKIPSD [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
SH3 domain proteins [cytosol] (Homo sapiens)
NCKIPSD [cytosol] (Homo sapiens)
Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
SH3 domain proteins [cytosol] (Homo sapiens)
NCKIPSD [cytosol] (Homo sapiens)
WIP binds WASP/N-WASP, activating them (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
SH3 domain proteins [cytosol] (Homo sapiens)
NCKIPSD [cytosol] (Homo sapiens)
SH3 domain proteins [cytosol] (Homo sapiens)
NCKIPSD [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
Attachment of preexisting mother filament and initiation of branching (Homo sapiens)
Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
SH3 domain proteins [cytosol] (Homo sapiens)
NCKIPSD [cytosol] (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
SH3 domain proteins [cytosol] (Homo sapiens)
NCKIPSD [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
SH3 domain proteins [cytosol] (Homo sapiens)
NCKIPSD [cytosol] (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
SH3 domain proteins [cytosol] (Homo sapiens)
NCKIPSD [cytosol] (Homo sapiens)
Src family kinases (SFKs) phosphorylate WASP/N-WASP (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
SH3 domain proteins [cytosol] (Homo sapiens)
NCKIPSD [cytosol] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
SH3 domain proteins [cytosol] (Homo sapiens)
NCKIPSD [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
SH3 domain proteins [cytosol] (Homo sapiens)
NCKIPSD [cytosol] (Homo sapiens)
Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
Activated WAVE2 and WASP/N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
SH3 domain proteins [cytosol] (Homo sapiens)
NCKIPSD [cytosol] (Homo sapiens)
WIP binds WASP/N-WASP, activating them (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
SH3 domain proteins [cytosol] (Homo sapiens)
NCKIPSD [cytosol] (Homo sapiens)
SH3 domain proteins [cytosol] (Homo sapiens)
NCKIPSD [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NZQ3 NCKIPSD
Gene Names
NCKIPSD, AF3P21, SPIN90
Chain
chain:1-722
Reference Genes
BioGPS Gene:51517 NCKIPSD
COSMIC (genes):NCKIPSD NCKIPSD
CTD Gene:51517 NCKIPSD
dbSNP Gene:51517 NCKIPSD
ENSEMBL:ENSG00000213672 NCKIPSD
HGNC:15486 NCKIPSD
KEGG Gene (Homo sapiens):51517 NCKIPSD
Monarch:51517 NCKIPSD
NCBI Gene:51517 NCKIPSD
OMIM:606671 NCKIPSD
UCSC:Q9NZQ3 NCKIPSD
Reference Transcript
RefSeq:NM_016453.3 NCKIPSD
RefSeq:NM_184231.2 NCKIPSD
Other Identifiers
0001770215
11720419_at
11749405_a_at
16953679
19267
218697_at
2673655
2673656
2673657
2673659
2673660
2673662
2673663
2673664
2673665
2673666
2673668
2673669
2673670
2673672
2673673
2673675
2673676
2673677
50005
51517
56174_at
6DEC
6DED
6DEE
8087182
A_23_P29638
A_33_P3288023
AAF35985
AAH16052
AAH26280
AAK09094
AAR83735
AB069981
AB069982
AC141002
AF178432
AF303581
AJ242655
AK294151
AY453794
BAB63204
BAB63205
BAG57476
BC016052
BC026280
C9JC20
C9JMQ4
C9JSC3
CAB019267
CAB65089
CCDS2776
CCDS46827
ENSG00000213672
ENSP00000294129
ENSP00000389059
ENST00000294129
ENST00000294129.6
ENST00000416649
ENST00000416649.6
EntrezGene:51517
EntrezGene:NCKIPSD
F8WCR8
g7705265_3p_at
GE54941
GO:0002376
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0005882
GO:0006810
GO:0007010
GO:0007165
GO:0008092
GO:0008150
GO:0008180
GO:0010976
GO:0016192
GO:0017124
GO:0030154
GO:0032991
GO:0038096
GO:0043226
GO:0048856
H7C0T9
HGNC:15486
HPA050005
ILMN_1736623
ILMN_2382271
IPR001452
IPR018556
IPR035514
IPR036028
MIM:606671
NCKIPSD
NCKIPSD-201
NCKIPSD-204
NM_016453
NM_184231
NP_057537
NP_909119
PF00018
PF09431
PH_hs_0029063
SM00326
TC03001387.hg
UPI0000000DFA
UPI0000135D86
XM_017006594
XM_017006595
XM_017006596
XM_017006597
XM_017006598
XM_017006599
XM_017006600
XP_016862083
XP_016862084
XP_016862085
XP_016862086
XP_016862087
XP_016862088
XP_016862089
XR_002959541
Participant Of
hasMember
SH3 domain proteins [cytosol]
Inferred To
NCKIPSD [cytosol] (Bos taurus)
NCKIPSD [cytosol] (Canis familiaris)
NCKIPSD [cytosol] (Danio rerio)
NCKIPSD [cytosol] (Drosophila melanogaster)
NCKIPSD [cytosol] (Gallus gallus)
NCKIPSD [cytosol] (Mus musculus)
NCKIPSD [cytosol] (Rattus norvegicus)
NCKIPSD [cytosol] (Sus scrofa)
NCKIPSD [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_057537.1
,
NP_909119.1
OpenTargets
ENSG00000213672
GeneCards
Q9NZQ3
PRO
Q9NZQ3
PDB
6DEE
,
6DEC
,
6DED
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06241 FYN
6
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y531-FYN [cytosol]
(R-HSA-391819)
p-Y420-FYN [cytosol]
(R-HSA-391821)
FYN [cytosol]
(R-HSA-200917)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
0.573
2
UniProt:Q9UQB8 BAIAP2
1
BAIAP2 [cytosol]
(R-HSA-442574)
0.573
2
UniProt:P62994 Grb2
3
GRB2-1 [plasma membrane]
(R-RNO-202993)
Grb2 [cytosol]
(R-RNO-55929)
GRB2-1 [cytosol]
(R-RNO-74686)
0.544
2
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