Reactome | NCKIPSD [cytosol]

NCKIPSD [cytosol]

Stable Identifier

R-HSA-2197671

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

WISH, NCK-interacting protein with SH3 domain, SPN90_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Parasite infection (Homo sapiens)
        
        Leishmania phagocytosis (Homo sapiens)
        
        FCGR3A-mediated phagocytosis (Homo sapiens)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)
        
        Detachment of WASP/WAVE (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)
        
        Src phosphorylate WASP,N-WASP (Homo sapiens)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)
        
        WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)
        
        WIP binds WASP,N-WASP, activating them (Homo sapiens)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
    - Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)
      - Detachment of WASP/WAVE (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)
      - Src phosphorylate WASP,N-WASP (Homo sapiens)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)
      - WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)
      - WIP binds WASP,N-WASP, activating them (Homo sapiens)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)
        
        Detachment of WASP/WAVE (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)
        
        Src phosphorylate WASP,N-WASP (Homo sapiens)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)
        
        WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)
        
        WIP binds WASP,N-WASP, activating them (Homo sapiens)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)
        
        SH3 domain proteins [cytosol] (Homo sapiens)
        
        NCKIPSD [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NZQ3 NCKIPSD

Gene Names

NCKIPSD, AF3P21, SPIN90

Chain

chain:1-722

Reference Genes

BioGPS Gene:51517 NCKIPSD

COSMIC (genes):NCKIPSD NCKIPSD

CTD Gene:51517 NCKIPSD

dbSNP Gene:51517 NCKIPSD

ENSEMBL:ENSG00000213672 NCKIPSD

HGNC:15486 NCKIPSD

KEGG:hsa:51517 NCKIPSD

Monarch:51517 NCKIPSD

NCBI Gene:51517 NCKIPSD

OMIM:606671 NCKIPSD

UCSC:Q9NZQ3 NCKIPSD

Reference Transcript

Participates

as a member of

SH3 domain proteins [cytosol] (Homo sapiens)

Inferred To

Dmel\CG2258 [cytosol] (Drosophila melanogaster)

NCKIPSD [cytosol] (Bos taurus)

NCKIPSD [cytosol] (Caenorhabditis elegans)

NCKIPSD [cytosol] (Canis familiaris)

NCKIPSD [cytosol] (Gallus gallus)

NCKIPSD [cytosol] (Sus scrofa)

Nckipsd [cytosol] (Mus musculus)

Nckipsd [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_909119.1, NP_057537.1

ENSEMBL

ENST00000416649, ENSP00000294129, ENSP00000389059, ENSG00000213672, ENST00000294129

OpenTargets

ENSG00000213672

GeneCards

NCKIPSD

HPA

ENSG00000213672-NCKIPSD

PRO

Q9NZQ3

Pharos - Targets

Q9NZQ3

GlyGen

Q9NZQ3

PDB

6DEC, 6DED, 6DEE

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.678	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.669	3
UniProt:O00233 PSMD9	1	PSMD9 [cytosol] (R-HSA-68810)	0.666	4
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.659	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.643	3
UniProt:P06241 FYN	6	FYN [cytosol] (R-HSA-200917) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y531-FYN [cytosol] (R-HSA-391819) p-S21,Y420-FYN [cytosol] (R-HSA-5218745)	0.573	2
UniProt:P62994 Grb2	3	Grb2 [cytosol] (R-RNO-55929) Grb2 [plasma membrane] (R-RNO-202993) Grb2 [cytosol] (R-RNO-74686)	0.544	2
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.527	2
UniProt:Q9Y2X7 GIT1	2	GIT1 [cytosol] (R-HSA-430326) p-Y383-GIT1 [cytosol] (R-HSA-3928463)	0.527	2
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.527	2
UniProt:Q14155 ARHGEF7	1	ARHGEF7 [cytosol] (R-HSA-430346)	0.527	2
UniProt:Q9UBC2 EPS15L1	2	EPS15L1 [plasma membrane] (R-HSA-182937) EPS15L1 [cytosol] (R-HSA-8935900)	0.527	2
UniProt:Q15811 ITSN1	1	ITSN1 [cytosol] (R-HSA-3006481)	0.527	2
UniProt:P48729 CSNK1A1	3	CSNK1A1 [nucleoplasm] (R-HSA-9943726) CSNK1A1 [cytosol] (R-HSA-195263) CSNK1A1 [cilium] (R-HSA-5632507)	0.527	2

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