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LY96 [endosome membrane]
Stable Identifier
R-HSA-2201307
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endosome membrane
Synonyms
MD2
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
Endocytosis of TLR4:LY96:LPS:CD14 (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Homo sapiens)
SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Homo sapiens)
Auto-ubiquitination of TRAF3 (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
IKKε (IKBKE) is phosphorylated within the activated TLR4 complex (Homo sapiens)
IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Homo sapiens)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Homo sapiens)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Homo sapiens)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Homo sapiens)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
Recruitment of IKKε (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Homo sapiens)
IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 (Homo sapiens)
IKKε (IKBKE) is ubiquitinated within the activated TLR4 (Homo sapiens)
IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
K63polyUb-IKBKE:K63polyUb-TANK:K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
OPTN binds TBK1 within the activated TLR4 complex (Homo sapiens)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Homo sapiens)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Homo sapiens)
K63polyUb-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4 (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TANK:K63-poly-Ub-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TANK:K63-poly-Ub-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TBK1 is phosphorylated within the activated TLR4 complex (Homo sapiens)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Homo sapiens)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TRAF3 binds TICAM1:activated TLR4 complex (Homo sapiens)
SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
IKK complex recruitment mediated by RIP1 (Homo sapiens)
IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Homo sapiens)
CHUK:IKBKB:IKBKG:K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Homo sapiens)
K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TRIF:activated TLR3/TLR4 complex recruits RIP1 (Homo sapiens)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Homo sapiens)
Activated TLR4:TICAM1 recruits TRAF6 (Homo sapiens)
SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Homo sapiens)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
Activation of TAK1 complex bound to activated TLR4 complex (Homo sapiens)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
Phosphorylated TAK1 leaves activated TLR receptor complex (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TRIF-mediated programmed cell death (Homo sapiens)
Caspase-8 processing within TLR4 complex (Homo sapiens)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
RIP3 binds TRIF to mediate necroptosis (Homo sapiens)
RIP3:TICAM1:activated TLR4 [endosome membrane] (Homo sapiens)
RIP3:RIP1:TICAM1:activated TLR4 [endosome membrane] (Homo sapiens)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
RIP3:TICAM1:activated TLR4 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TRIF:activated TLR4 [endosome membrane] (Homo sapiens)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TLR4-induced ripoptosome assembly (Homo sapiens)
K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Homo sapiens)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Homo sapiens)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
Caspase activation via Death Receptors in the presence of ligand (Homo sapiens)
Caspase-8 processing within TLR4 complex (Homo sapiens)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96 [endosome membrane] (Homo sapiens)
LY96 [endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y6Y9 LY96
Gene Names
LY96, ESOP1, MD2
Chain
signal peptide:1-18, chain:19-160
Reference Genes
BioGPS Gene:23643 LY96
COSMIC (genes):LY96 LY96
CTD Gene:23643 LY96
dbSNP Gene:23643 LY96
ENSEMBL:ENSG00000154589 LY96
ENSEMBL_homo_sapiens_GENE:ENSG00000154589.7 LY96
HGNC:17156 LY96
KEGG Gene (Homo sapiens):23643 LY96
Monarch:23643 LY96
NCBI Gene:23643 LY96
OMIM:605243 LY96
UCSC:Q9Y6Y9 LY96
Reference Transcript
RefSeq:NM_015364.4 LY96
RefSeq:NM_001195797.1 LY96
Other Identifiers
11728507_at
17070061
206584_PM_at
206584_at
23643
3103525
3103526
3103530
3103531
3103532
3103534
3103536
33956_at
8146934
A_23_P94230
GE53507
GO:0001530
GO:0001875
GO:0002224
GO:0002376
GO:0005515
GO:0005576
GO:0005768
GO:0005886
GO:0006954
GO:0006968
GO:0007166
GO:0008289
GO:0010008
GO:0015026
GO:0023052
GO:0031410
GO:0031663
GO:0031666
GO:0032496
GO:0032497
GO:0032760
GO:0034142
GO:0035662
GO:0043226
GO:0043235
GO:0045087
GO:0046696
GO:0060089
GO:0071222
GO:0098542
HMNXSV003041703
ILMN_1724533
PH_hs_0004099
TC08000487.hg
g7662503_3p_at
Participates
as a component of
TLR4:LY96 [endosome membrane] (Homo sapiens)
Other forms of this molecule
LY96 [extracellular region]
2xN4GlycoAsn-LY96 [plasma membrane]
Inferred To
Ly96 [endosome membrane]
(Mus musculus)
Ly96 [endosome membrane]
(Rattus norvegicus)
LY96 [endosome membrane]
(Bos taurus)
LY96 [endosome membrane]
(Canis familiaris)
LY96 [endosome membrane]
(Gallus gallus)
LY96 [endosome membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001182726.1
,
NP_056179.3
Guide to Pharmacology - Targets
2890
OpenTargets
ENSG00000154589
GeneCards
Q9Y6Y9
HPA
ENSG00000154589-LY96
Ensembl
ENSP00000284818
,
ENST00000284818
,
ENSG00000154589
,
ENST00000518893
,
ENSP00000430533
PRO
Q9Y6Y9
Pharos - Targets
Q9Y6Y9
HMDB Protein
HMDBP13763
PDB
3FXI
,
2E56
,
2Z65
,
4G8A
,
3ULA
,
2E59
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00206-1 TLR4
0.822
5
UniProt:O00206 TLR4
2
TLR4 [endosome membrane]
(R-HSA-2201285)
2xN4GlycoAsn-TLR4 [plasma membrane]
(R-HSA-166045)
0.743
7
UniProt:Q14696 MESD
0.556
3
UniProt:P80188 LCN2
2
LCN2 [specific granule lumen]
(R-HSA-6799614)
LCN2 [extracellular region]
(R-HSA-5215934)
0.556
3
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