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MyrG-p-S16-TICAM2 [endosome membrane]
Stable Identifier
R-HSA-2201336
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endosome membrane
Synonyms
TRAM
Icon
Locations in the PathwayBrowser for interactor UniProt:O00206
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
Endocytosis of TRAM (TICAM2) (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) (Homo sapiens)
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86XR7 TICAM2
Gene Names
TICAM2, TIRAP3, TIRP, TRAM
Chain
initiator methionine:1, chain:2-235
Reference Genes
BioGPS Gene:100302736 TICAM2
BioGPS Gene:353376 TICAM2
COSMIC (genes):TICAM2 TICAM2
CTD Gene:100302736 TICAM2
CTD Gene:353376 TICAM2
dbSNP Gene:100302736 TICAM2
dbSNP Gene:353376 TICAM2
ENSEMBL:ENSG00000243414 TICAM2
HGNC:21354 TICAM2
KEGG Gene (Homo sapiens):100302736 TICAM2
KEGG Gene (Homo sapiens):353376 TICAM2
Monarch:100302736 TICAM2
Monarch:353376 TICAM2
NCBI Gene:100302736 TICAM2
NCBI Gene:353376 TICAM2
OMIM:608321 TICAM2
UCSC:Q86XR7 TICAM2
Reference Transcript
RefSeq:NM_001164469.3 TICAM2
RefSeq:NM_021649.7 TICAM2
RefSeq:NM_001164468.3 TICAM2
Other Identifiers
0004610546
11730553_a_at
11745544_a_at
11758448_s_at
228234_at
239431_at
2871828
2871829
2871830
2871831
2871832
2871833
2871834
2871835
2871836
2871837
2871846
2871847
2871848
2871849
353376
61865_at
85251_at
A_33_P3327270
GE62694
GO:0001891
GO:0002376
GO:0002756
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005768
GO:0005769
GO:0005770
GO:0005783
GO:0005793
GO:0005794
GO:0005886
GO:0006810
GO:0006886
GO:0006888
GO:0006909
GO:0006950
GO:0006954
GO:0007030
GO:0007165
GO:0007249
GO:0008150
GO:0008219
GO:0010008
GO:0015031
GO:0016020
GO:0016192
GO:0030134
GO:0030667
GO:0031410
GO:0031901
GO:0031902
GO:0034128
GO:0034142
GO:0034145
GO:0035666
GO:0035669
GO:0042995
GO:0043123
GO:0043226
GO:0043312
GO:0045087
GO:0070266
GO:0071222
GO:0071651
GO:0097190
GO:2000494
HMNXSV003015098
Hs.114055.0.A1_3p_at
Hs.184418.0.A1_3p_at
ILMN_1651346
PH_hs_0034823
Participates
as an output of
Endocytosis of TRAM (TICAM2) (Homo sapiens)
as an input of
TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) (Homo sapiens)
as a component of
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
Other forms of this molecule
MyrG-p-S16-TICAM2 [plasma membrane]
MyrG-p-S16-TICAM2 [secretory granule membrane]
Inferred To
Ghost homologue of MyrG-p-S16-TICAM2 [endosome membrane]
(Canis familiaris)
Ghost homologue of MyrG-p-S16-TICAM2 [endosome membrane]
(Gallus gallus)
Ghost homologue of MyrG-p-S16-TICAM2 [endosome membrane]
(Mus musculus)
Ghost homologue of MyrG-p-S16-TICAM2 [endosome membrane]
(Sus scrofa)
Modified Residues
Name
N-myristoylglycine at 2
Coordinate
2
PsiMod Name
N-myristoylglycine [MOD:00068]
PsiMod Definition
A protein modification that effectively converts a glycine residue to N-myristoylglycine.
Name
O-phospho-L-serine at 16
Coordinate
16
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_067681.1
,
NP_001157941.1
,
NP_001157940.1
OpenTargets
ENSG00000243414
HPA
ENSG00000243414-TICAM2
GeneCards
Q86XR7
Ensembl
ENSG00000243414
,
ENSP00000415139
,
ENST00000427199
PRO
Q86XR7
PDB
2M1W
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00206 TLR4
2
2xN4GlycoAsn-TLR4 [plasma membrane]
(R-HSA-166045)
TLR4 [endosome membrane]
(R-HSA-2201285)
0.678
3
UniProt:Q6SZW1 SARM1
0.592
2
UniProt:P50222 MEOX2
0.556
3
UniProt:Q96HA8 NTAQ1
0.556
3
UniProt:P0C6I1-PRO_0000324727 C
0.463
2
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