Reactome | COLEC11 [extracellular region]

COLEC11 [extracellular region]

Stable Identifier

R-HSA-2203477

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Collectin-11, COL11_HUMAN, CL-K1

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Complement cascade (Homo sapiens)
    - Initial triggering of complement (Homo sapiens)
      - Conversion of C2 into C2a and C2b (Homo sapiens)
        
        C4 activators [plasma membrane] (Homo sapiens)
        
        CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Homo sapiens)
        
        CL-LK:MASP1 dimer:MASP2 dimer [extracellular region] (Homo sapiens)
        
        CL-LK [extracellular region] (Homo sapiens)
        
        COLEC11 [extracellular region] (Homo sapiens)
      - Conversion of C4 into C4a and C4b (Homo sapiens)
        
        C4 activators [plasma membrane] (Homo sapiens)
        
        CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Homo sapiens)
        
        CL-LK:MASP1 dimer:MASP2 dimer [extracellular region] (Homo sapiens)
        
        CL-LK [extracellular region] (Homo sapiens)
        
        COLEC11 [extracellular region] (Homo sapiens)
      - Creation of C4 and C2 activators (Homo sapiens)
        
        Lectin pathway of complement activation (Homo sapiens)
        
        CL-LK binds carbohydrates on target cell surface (Homo sapiens)
        
        CL-LK:MASP1 dimer:MASP2 dimer [extracellular region] (Homo sapiens)
        
        CL-LK [extracellular region] (Homo sapiens)
        
        COLEC11 [extracellular region] (Homo sapiens)
        
        CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Homo sapiens)
        
        CL-LK:MASP1 dimer:MASP2 dimer [extracellular region] (Homo sapiens)
        
        CL-LK [extracellular region] (Homo sapiens)
        
        COLEC11 [extracellular region] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Binding and Uptake of Ligands by Scavenger Receptors (Homo sapiens)
  - Scavenging by Class A Receptors (Homo sapiens)
    - COLEC11 binds ligands (Homo sapiens)
      - COLEC11:Ligand [extracellular region] (Homo sapiens)
        
        COLEC11:MASP1 [extracellular region] (Homo sapiens)
        
        COLEC11 Oligomer [extracellular region] (Homo sapiens)
        
        COLEC11 Trimer [extracellular region] (Homo sapiens)
        
        COLEC11 [extracellular region] (Homo sapiens)
      - COLEC11:MASP1 [extracellular region] (Homo sapiens)
        
        COLEC11 Oligomer [extracellular region] (Homo sapiens)
        
        COLEC11 Trimer [extracellular region] (Homo sapiens)
        
        COLEC11 [extracellular region] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
17179669	Identification and characterization of a novel human collectin CL-K1 Fukuda, M, Sakamoto, T, Keshi, H, Jang, SJ, Kawai, T, Yoshizaki, T, Koyama, S, Motomura, W, Fukuzawa, J, Yoshida, I, Fukuoh, A, Ohtani, K, Wakamiya, N, Suzuki, Y, Katoh, T	Microbiol Immunol	2006

External Reference Information

External Reference

UniProt:Q9BWP8 COLEC11

Gene Names

COLEC11, UNQ596/PRO1182

Chain

signal peptide:1-25, chain:26-271

Reference Genes

BioGPS Gene:78989 COLEC11

COSMIC (genes):COLEC11 COLEC11

CTD Gene:78989 COLEC11

dbSNP Gene:78989 COLEC11

ENSEMBL:ENSG00000118004 COLEC11

ENSEMBL_homo_sapiens_GENE:ENSG00000118004.18 COLEC11

HGNC:17213 COLEC11

KEGG Gene (Homo sapiens):78989 COLEC11

Monarch:78989 COLEC11

NCBI Gene:78989 COLEC11

OMIM:612502 COLEC11

UCSC:Q9BWP8 COLEC11

Reference Transcript

Other Identifiers

11730000_a_at

16876670

219873_PM_at

219873_at

2467212

2467213

2467214

2467215

2467217

2467218

2467222

2467226

2467234

2467239

2467240

2467241

2467242

64244_at

78989

8040045

A_23_P120125

A_24_P388322

GO:0001867

GO:0002376

GO:0002682

GO:0002752

GO:0003677

GO:0005509

GO:0005515

GO:0005537

GO:0005576

GO:0005581

GO:0005615

GO:0005886

GO:0006508

GO:0006956

GO:0009897

GO:0012501

GO:0016192

GO:0019730

GO:0023052

GO:0030246

GO:0032502

GO:0042802

GO:0042806

GO:0045087

GO:0046872

GO:0070492

GO:0097194

GO:0098542

GO:0120153

GO:1903028

GO:1905370

HMNXSV003023786

HMNXSV003031062

ILMN_1735192

ILMN_2298189

ILMN_2414268

PH_hs_0002751

PH_hs_0031146

TC02000023.hg

g13128971_3p_at

Participates

as a component of

Inferred To

COLEC11 [extracellular region] (Bos taurus)

COLEC11 [extracellular region] (Gallus gallus)

COLEC11 [extracellular region] (Mus musculus)

COLEC11 [extracellular region] (Sus scrofa)

Ghost homologue of COLEC11 [extracellular region] (Canis familiaris)

Ghost homologue of COLEC11 [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_954705.1, NP_001242911.1, NP_001242913.1, NP_001242916.1, NP_001242912.1, NP_001242918.1, NP_001242915.1, NP_001242917.1, NP_076932.1, NP_001242914.1

OpenTargets

ENSG00000118004

GeneCards

Q9BWP8

HPA

ENSG00000118004-COLEC11

Ensembl

ENSP00000385130, ENSP00000339168, ENST00000404205, ENSP00000411770, ENSP00000385827, ENSP00000371494, ENSP00000385653, ENST00000402794, ENST00000349077, ENSG00000118004, ENSP00000236693, ENSP00000384882, ENST00000382062, ENST00000403096, ENST00000236693, ENST00000418971, ENST00000402922

PRO

Q9BWP8

Pharos - Targets

Q9BWP8

Orphanet

19845

PDB

4YLI, 4YMD