Auto-ubiquitination of TRAF3

Stable Identifier
R-HSA-2213017
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

TRIF signaling activates TRAF3 self-mediated polyubiquitination trough Lys-63 of ubiquitin. The ubiquitinated TRAF3 in turn activates the interferon response (Tseng PH et al. 2010).

Literature References
PubMed ID Title Journal Year
19898473 Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

Tseng, PH, Matsuzawa, A, Zhang, W, Mino, T, Vignali, DA, Karin, M

Nat Immunol 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed