Auto-ubiquitination of TRAF3

Stable Identifier
R-HSA-2213017
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

TRIF signaling activates TRAF3 self-mediated polyubiquitination trough Lys-63 of ubiquitin. The ubiquitinated TRAF3 in turn activates the interferon response (Tseng PH et al. 2010).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
Physical Entity
Activity
Orthologous Events