Anchoring fibril formation

Stable Identifier
R-HSA-2214320
Type
Pathway
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Anchoring fibril formation
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Collagen VII forms anchoring fibrils, composed of antiparallel dimers that connect the dermis to the epidermis (Bruckner-Tuderman 2009, Has & Kern 2010). During fibrillogenesis, the nascent type VII procollagen molecules dimerize in an antiparallel manner. The C-propeptide is then removed by Bone morphogenetic protein 1 (Rattenholl et al. 2002) and the processed antiparallel dimers laterally aggregate (Villone et al. 2008, Gordon & Hahn 2010).
Literature References
PubMed ID Title Journal Year
19945621 Type VII collagen: the anchoring fibril protein at fault in dystrophic epidermolysis bullosa

Uitto, J, Chung, HJ

Dermatol Clin 2010
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Events
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as an event of
Event Information
Go Biological Process
collagen fibril organization (0030199)
Orthologous Events
Anchoring fibril formation (Caenorhabditis elegans)
Anchoring fibril formation (Mus musculus)
Anchoring fibril formation (Rattus norvegicus)
Anchoring fibril formation (Sus scrofa)
Anchoring fibril formation (Xenopus tropicalis)
Authored
Jupe, S  (2012-04-30)
Reviewed
Raleigh, S  (2012-10-08)
Ricard-Blum, S  (2012-11-19)
Kalamajski, S  (2012-10-08)
Created
Jupe, S  (2012-04-30)
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