Anchoring fibril formation

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R-HSA-2214320
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Pathway
Species
Homo sapiens
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Collagen VII forms anchoring fibrils, composed of antiparallel dimers that connect the dermis to the epidermis (Bruckner-Tuderman 2009, Has & Kern 2010). During fibrillogenesis, the nascent type VII procollagen molecules dimerize in an antiparallel manner. The C-propeptide is then removed by Bone morphogenetic protein 1 (Rattenholl et al. 2002) and the processed antiparallel dimers laterally aggregate (Villone et al. 2008, Gordon & Hahn 2010).

Literature References
PubMed ID Title Journal Year
19945621 Type VII collagen: the anchoring fibril protein at fault in dystrophic epidermolysis bullosa

Chung, HJ, Uitto, J

Dermatol Clin 2010
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