Reactome | PDPK1 binds PIP2

PDPK1 binds PIP2

Stable Identifier

R-HSA-2219524

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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PDPK1 (PDK1) possesses low affinity for PIP2, so small amounts of PDPK1 are always present at the membrane, in the absence of PI3K activity (Currie et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
9895304	Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1 Alessi, DR, Cohen, P, Downes, CP, Casamayor, A, Lucocq, J, Currie, RA, Deak, M, Gray, A, Walker, KS	Biochem J	1999