NOTCH2 binds CNTN1

Stable Identifier
R-HSA-2220816
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

CNTN1 (F3, contactin-1) is a neuronal cell adhesion protein that can bind and activate NOTCH2, as well as NOTCH1, and these interactions are thought to play a role in oligodendrocyte maturation. While NOTCH1 activation by CNTN1 was shown to be deltex-dependent, the involvement of deltex in CNTN1-mediated activation of NOTCH2, although likely, has not been examined (Hu et al. 2003).

Literature References
Participants
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