NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC

Stable Identifier
R-HSA-2220957
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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MAML is expected to recruit CDK8 to NICD1 PEST domain mutants like it recruits CDK8 to wild-type NICD1 (Fryer et al. 2004).

Literature References
PubMed ID Title Journal Year
15546612 Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

Fryer, CJ, White, JB, Jones, KA

Mol Cell 2004
Participants
Participant Of
Normal reaction
Disease
Name Identifier Synonyms
T-cell leukemia 715
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created