NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC

Stable Identifier
R-HSA-2220957
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC
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MAML is expected to recruit CDK8 to NICD1 PEST domain mutants like it recruits CDK8 to wild-type NICD1 (Fryer et al. 2004).

Literature References
PubMed ID Title Journal Year
15546612 Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

Fryer, CJ, White, JB, Jones, KA

Mol Cell 2004
Participants
Input
Output
Participant Of
hasEvent
Normal reaction
MAML in complex with NICD1 recruits CDK8 (Homo sapiens)
Disease
Name Identifier Synonyms
T-cell leukemia 715
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M  (2013-01-04)
Reviewed
Haw, R  (2013-02-10)
Created
Orlic-Milacic, M  (2012-05-03)