NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML

Stable Identifier
R-HSA-2220964
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML
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NICD1 PEST domain mutants in complex with RBPJ and SNW1 are expected, similar to the wild-type NICD1:RBPJ:SNW1 complex, to recruit MAML and histone acetylatransferases to form the NOTCH1 PEST domain mutants coactivator complex (Fryer et al. 2002, Wallberg et al. 2002, Nam et al. 2006).
Literature References
PubMed ID Title Journal Year
12050117 Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex

Fryer, CJ, Lamar, E, Jones, KA, Kintner, C, Turbachova, I

Genes Dev 2002
12391150 p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro

Lendahl, U, Wallberg, AE, Pedersen, K, Roeder, RG

Mol Cell Biol 2002
16530044 Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes

Blacklow, SC, Nam, Y, Aster, JC, Song, L, Sliz, P

Cell 2006
Participants
Input
Output
Participates
as an event of
Normal reaction
NICD1 in complex with RBPJ (CSL) recruits MAML (Homo sapiens)
Functional status

Gain of function of NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
T-cell acute lymphoblastic leukemia DOID:5603
Authored
Orlic-Milacic, M  (2013-01-04)
Reviewed
Haw, R  (2013-02-10)
Created
Orlic-Milacic, M  (2012-05-03)
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