NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML

Stable Identifier
R-HSA-2220964
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NICD1 PEST domain mutants in complex with RBPJ and SNW1 are expected, similar to the wild-type NICD1:RBPJ:SNW1 complex, to recruit MAML and histone acetylatransferases to form the NOTCH1 PEST domain mutants coactivator complex (Fryer et al. 2002, Wallberg et al. 2002, Nam et al. 2006).

Literature References
PubMed ID Title Journal Year
12391150 p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro

Wallberg, AE, Pedersen, K, Lendahl, U, Roeder, RG

Mol Cell Biol 2002
12050117 Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex

Fryer, CJ, Lamar, E, Turbachova, I, Kintner, C, Jones, KA

Genes Dev 2002
16530044 Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes

Nam, Y, Sliz, P, Song, L, Aster, JC, Blacklow, SC

Cell 2006
Participants
Participant Of
Normal reaction
Disease
Name Identifier Synonyms
T-cell leukemia 715
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created