CDK8 phosphorylates NICD1 PEST domain mutants

Stable Identifier
R-HSA-2220971
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CDK8 phosphorylates NICD1 PEST domain mutants
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

While CDK8 can probably phosphorylate the TAD domain of NICD1 PEST domain mutants, it cannot phosphorylate the PEST domain of these mutants as it is partially or completely truncated (Fryer et al. 2004).

Literature References
PubMed ID Title Journal Year
15546612 Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

Fryer, CJ, White, JB, Jones, KA

Mol Cell 2004
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
cyclin-dependent protein serine/threonine kinase activity of NOTCH1 PEST Domain Mutants Coactivator Complex:CDK8:CCNC [nucleoplasm]
Physical Entity
NOTCH1 PEST Domain Mutants Coactivator Complex:CDK8:CCNC [nucleoplasm]
Activity
cyclin-dependent protein serine/threonine kinase activity (0004693)
Normal reaction
NICD1 is phosphorylated by CDK8 (Homo sapiens)
Disease
Name Identifier Synonyms
T-cell leukemia 715
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M  (2013-01-04)
Reviewed
Haw, R  (2013-02-10)
Created
Orlic-Milacic, M  (2012-05-03)
Cite Us!