NOTCH1 PEST domain mutants stimulate HES1 transcription

Stable Identifier
R-HSA-2220979
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
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NOTCH1 PEST domain mutants stimulate HES1 transcription
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NICD1 PEST domain mutants are expected to stimulate HES1 transcription in a similar manner to wild-type NICD1 (Jarriault et al. 1995).

Literature References
PubMed ID Title Journal Year
7566092 Signalling downstream of activated mammalian Notch

Jarriault, S, Brou, C, Logeat, F, Schroeter, EH, Kopan, R, Israel, A

Nature 1995
Participants
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Output
Participant Of
hasEvent
This event is regulated
Positively by
Normal reaction
NOTCH1 stimulates HES1 transcription (Homo sapiens)
Disease
Name Identifier Synonyms
T-cell leukemia 715
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M  (2013-01-04)
Reviewed
Haw, R  (2013-02-10)
Created
Orlic-Milacic, M  (2012-05-03)