NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants

Stable Identifier
R-HSA-2220988
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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NEXT1 PEST domain mutant fragments are expected to be cleaved by the gamma-secretase complex at the S3 site in a similar manner to wild-type NEXT1 (Schroeter et al. 1998, De Strooper et al. 1999, Huppert et al. 2000, Fortini 2002, Rustighi et al. 2009).

Literature References
PubMed ID Title Journal Year
19151708 The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer

Rustighi, A, Tiberi, L, Soldano, A, Napoli, M, Nuciforo, P, Rosato, A, Kaplan, F, Capobianco, A, Pece, S, Di Fiore, PP, Del Sal, G

Nat Cell Biol 2009
10879540 Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1

Huppert, SS, Le, A, Schroeter, EH, Mumm, JS, Saxena, MT, Milner, LA, Kopan, R

Nature 2000
12209127 Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling

Fortini, ME

Nat Rev Mol Cell Biol 2002
9620803 Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

Schroeter, EH, Kisslinger, JA, Kopan, R

Nature 1998
10206645 A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

De Strooper, B, Annaert, W, Cupers, P, Saftig, P, Craessaerts, K, Mumm, JS, Schroeter, EH, Schrijvers, V, Wolfe, MS, Ray, WJ, Goate, A, Kopan, R

Nature 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]
Physical Entity
Activity
Normal reaction
Disease
Name Identifier Synonyms
T-cell leukemia 715
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created