Reactome | Hemoglobin:Haptoglobin:CD163 is endocytosed

Hemoglobin:Haptoglobin:CD163 is endocytosed

Stable Identifier

R-HSA-2230938

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, endocytic vesicle membrane

ReviewStatus

5/5

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Hemoglobin:Haptoglobin:CD163 is endocytosed

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The CD163:haptoglobin:hemoglobin complex is endocytosed (Schaer et al. 2006, Kristiansen et al. 2001) by monocytes or macrophages. CD163 is constitutively endocytosed by monocytes independently of ligand binding (Schaer et al. 2006). Upon endocytosis, the receptor–ligand complex enters early endosomes where haptoglobin:hemoglobin complexes are released from CD163. The receptor then recycles to the cell surface while haptoglobin:hemoglobin complexes continue through the endocytic pathway to end up in lysosomes where the protein moieties and the ligand are degraded.

Literature References

PubMed ID	Title	Journal	Year
17008602	Constitutive endocytosis of CD163 mediates hemoglobin-heme uptake and determines the noninflammatory and protective transcriptional response of macrophages to hemoglobin Schaer, CA, Schoedon, G, Imhof, A, Kurrer, MO, Schaer, DJ	Circ. Res.	2006
16189277	CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin Schaer, DJ, Schaer, CA, Buehler, PW, Boykins, RA, Schoedon, G, Alayash, AI, Schaffner, A	Blood	2006
11196644	Identification of the haemoglobin scavenger receptor Kristiansen, M, Graversen, JH, Jacobsen, C, Sonne, O, Hoffman, HJ, Law, SK, Moestrup, SK	Nature	2001