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ZNF669 [nucleoplasm]
Stable Identifier
R-HSA-2248869
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Zinc finger protein 669, ZN669_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Regulation of endogenous retroelements (Homo sapiens)
Regulation of endogenous retroelements by KRAB-ZFP proteins (Homo sapiens)
ATF7IP:SETDB1 binds SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin (Homo sapiens)
ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
ZNF669 [nucleoplasm] (Homo sapiens)
SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
ZNF669 [nucleoplasm] (Homo sapiens)
CBX5 (HP-1alpha) binds TRIM28 (KAP1) in SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin (Homo sapiens)
CBX5:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement [nucleoplasm] (Homo sapiens)
SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
ZNF669 [nucleoplasm] (Homo sapiens)
SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
ZNF669 [nucleoplasm] (Homo sapiens)
KRAB-ZFP binds retroelement DNA in chromatin (Homo sapiens)
KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
ZNF669 [nucleoplasm] (Homo sapiens)
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
ZNF669 [nucleoplasm] (Homo sapiens)
NuRD complex binds SUMO2-6K-TRIM28:KRAB-ZNF:retroelement (Homo sapiens)
NuRD:SUMO2-6K-TRIM28:KRAB-ZNF:retroelement chromatin [nucleoplasm] (Homo sapiens)
SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
ZNF669 [nucleoplasm] (Homo sapiens)
SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
ZNF669 [nucleoplasm] (Homo sapiens)
SETDB1 in ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement trimethylates lysine-9 of histone H3 in nucleosomes (Homo sapiens)
ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
ZNF669 [nucleoplasm] (Homo sapiens)
ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin with H3K9me3 [nucleoplasm] (Homo sapiens)
KRAB-ZFP:retroelement chromatin with H3K9me3 [nucleoplasm] (Homo sapiens)
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
ZNF669 [nucleoplasm] (Homo sapiens)
TRIM28 (KAP1) binds KRAB-ZFP in KRAB-ZFP:retroelement chromatin (Homo sapiens)
KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
ZNF669 [nucleoplasm] (Homo sapiens)
TRIM28:KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
ZNF669 [nucleoplasm] (Homo sapiens)
TRIM28 in TRIM28:KRAB-ZFP:retroelement chromatin autoSUMOylates with SUMO2 (Homo sapiens)
SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
ZNF669 [nucleoplasm] (Homo sapiens)
TRIM28:KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFP:retroelement chromatin [nucleoplasm] (Homo sapiens)
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
ZNF669 [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
KRAB-ZNF / KAP Interaction (Homo sapiens)
KRAB-ZNF / KAP Complex [nucleoplasm] (Homo sapiens)
KRAB-ZNF [nucleoplasm] (Homo sapiens)
ZNF669 [nucleoplasm] (Homo sapiens)
KRAB-ZNF [nucleoplasm] (Homo sapiens)
ZNF669 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96BR6 ZNF669
Gene Names
ZNF669
Chain
chain:1-464
Reference Genes
BioGPS Gene:79862 ZNF669
COSMIC (genes):ZNF669 ZNF669
CTD Gene:79862 ZNF669
dbSNP Gene:79862 ZNF669
ENSEMBL:ENSG00000188295 ZNF669
HGNC:25736 ZNF669
KEGG:hsa:79862 ZNF669
Monarch:79862 ZNF669
NCBI Gene:79862 ZNF669
UCSC:Q96BR6 ZNF669
Reference Transcript
RefSeq:NM_001142572.1 ZNF669
RefSeq:NM_024804.2 ZNF669
Other Identifiers
11740878_x_at
11755064_x_at
16701503
220215_3p_at
220215_PM_at
220215_at
2465523
2465524
2465525
2465526
2465527
2465528
2465529
2465530
2465531
2465532
2465533
2465534
3821586
7925677
79862
82218_at
88497_at
A_23_P86386
A_33_P3339687
GE82949
GO:0000977
GO:0000981
GO:0003677
GO:0005515
GO:0005634
GO:0006355
GO:0006357
GO:0043226
GO:0046872
GO:0140110
HMNXSV003054672
ILMN_1770172
ILMN_2093748
PH_hs_0029287
PH_hs_0031942
TC01004064.hg
Participates
as a candidate of
KRAB-ZFPs that bind, repress retroelements [nucleoplasm] (Homo sapiens)
KRAB-ZNF [nucleoplasm] (Homo sapiens)
Inferred To
sens-2 [nucleoplasm]
(Drosophila melanogaster)
Homologues of ZNF669 [nucleoplasm]
(Drosophila melanogaster)
Homologues of ZNF669 [nucleoplasm]
(Gallus gallus)
ZNF669 [nucleoplasm]
(Drosophila melanogaster)
ZNF669 [nucleoplasm]
(Gallus gallus)
ZNF669 [nucleoplasm]
(Sus scrofa)
ZNF77 [nucleoplasm]
(Bos taurus)
Cross References
ENSEMBL
ENSP00000342818
,
ENST00000343381
,
ENSP00000404370
,
ENST00000448299
OpenTargets
ENSG00000188295
HPA
ENSG00000188295-ZNF669
PRO
Q96BR6
Pharos - Targets
Q96BR6
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.556
3
UniProt:Q9NYA4 MTMR4
2
MTMR4 [cytosol]
(R-HSA-1604658)
MTMR4 [early endosome membrane]
(R-HSA-2187404)
0.527
2
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.527
2
UniProt:O95749 GGPS1
1
GGPS1 [cytosol]
(R-HSA-191415)
0.527
2
UniProt:Q14999 CUL7
1
CUL7 [cytosol]
(R-HSA-535534)
0.527
2
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