Formation of lysyl-pyrrole cross-links

Stable Identifier
R-HSA-2250301
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Trivalent collagen cross-links can also form as pyrroles. Lysyl-Pyrrole (L-Pyrrole) is formed when Lysino-ketonorleucine (LKNL) reacts with Hydroxylysino-norleucine (deH-HLNL) (Eyre et al. 2008), with structures based on a 3-hydroxypyrrole, believed to be the core structure of the pyrrole cross-links in bone collagen, rather than a pyrrole lacking a hydroxyl on the ring as depicted earlier.

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Orthologous Events