Formation of lysyl-pyrrole cross-links

Stable Identifier
R-HSA-2250301
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

Trivalent collagen cross-links can also form as pyrroles. Lysyl-Pyrrole (L-Pyrrole) is formed when Lysino-ketonorleucine (LKNL) reacts with Hydroxylysino-norleucine (deH-HLNL) (Eyre et al. 2008), with structures based on a 3-hydroxypyrrole, believed to be the core structure of the pyrrole cross-links in bone collagen, rather than a pyrrole lacking a hydroxyl on the ring as depicted earlier.

Literature References
PubMed ID Title Journal Year
12211432 Mechanical properties of adult vertebral cancellous bone: correlation with collagen intermolecular cross-links

Banse, X, Sims, TJ, Bailey, AJ

J. Bone Miner. Res. 2002
A collagen-associated Ehrlich chromogen: a pyrrolic cross-link?

Scott, JE, Hughes, EW, Shuttleworth, A

Bioscience Reports 1981
1567360 Identification of the loci of the collagen-associated Ehrlich chromogen in type I collagen confirms its role as a trivalent cross-link

Kuypers, R, Tyler, M, Kurth, LB, Jenkins, ID, Horgan, DJ

Biochem J 1992
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