RALA exchanges GDP for GTP

Stable Identifier
R-HSA-2255342
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytoplasmic vesicle membrane
Synonyms
Activation of RALA
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RALA exchanges GDP for GTP
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RALA releases GDP and binds GTP, producing the active form of RALA. The reaction is accelerated by guanine nucleotide exchange factors (GEFs) and opposed by GTPase-activating proteins (GAPs) which enhance the conversion of RALA:GTP back to RALA:GDP by activating the GTPase activity of RALA.

Literature References
PubMed ID Title Journal Year
8094051 Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase

Albright, CF, Giddings, BW, Liu, J, Vito, M, Weinberg, RA

EMBO J. 1993
2550440 Identification of the ral and rac1 gene products, low molecular mass GTP-binding proteins from human platelets

Polakis, PG, Weber, RF, Nevins, B, Didsbury, JR, Evans, T, Snyderman, R

J. Biol. Chem. 1989
Participants
Input
Output
Participant Of
hasEvent
Inferred From
RalA Exchanges GDP for GTP (Mus musculus)
Authored
May, B  (2012-05-16)
Reviewed
Klip, A  (2012-08-21)
Created
May, B  (2012-05-19)