RALA releases GDP and binds GTP, producing the active form of RALA. The reaction is accelerated by guanine nucleotide exchange factors (GEFs) and opposed by GTPase-activating proteins (GAPs) which enhance the conversion of RALA:GTP back to RALA:GDP by activating the GTPase activity of RALA.
Weber, RF, Snyderman, R, Evans, T, Didsbury, JR, Polakis, PG, Nevins, B
Weinberg, RA, Liu, J, Albright, CF, Giddings, BW, Vito, M
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