RAB8A,10,13,14 exchange GDP for GTP

Stable Identifier
R-HSA-2255343
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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RAB8A/10/13/14 release GDP and bind GTP to yield the active complex. Guanine nucleotide exchange factors (GEFs) stimulate the reaction. GTPase-activating proteins (GAPs) oppose the reaction by stimulating the intrinsic GTPase activity of the RAB proteins.
Literature References
PubMed ID Title Journal Year
20937701 Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors

Linford, A, Rigden, DJ, Barr, FA, Gerondopoulos, A, Yoshimura, S

J. Cell Biol. 2010
20631154 Interaction of retinitis pigmentosa GTPase regulator (RPGR) with RAB8A GTPase: implications for cilia dysfunction and photoreceptor degeneration

Peranen, J, Murga-Zamalloa, CA, Khanna, H, Swaroop, A, Atkins, SJ

Hum. Mol. Genet. 2010
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