RAB8A,10,13,14 exchange GDP for GTP

Stable Identifier
R-HSA-2255343
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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RAB8A/10/13/14 release GDP and bind GTP to yield the active complex. Guanine nucleotide exchange factors (GEFs) stimulate the reaction. GTPase-activating proteins (GAPs) oppose the reaction by stimulating the intrinsic GTPase activity of the RAB proteins.

Literature References
PubMed ID Title Journal Year
20631154 Interaction of retinitis pigmentosa GTPase regulator (RPGR) with RAB8A GTPase: implications for cilia dysfunction and photoreceptor degeneration

Murga-Zamalloa, CA, Atkins, SJ, Peranen, J, Swaroop, A, Khanna, H

Hum. Mol. Genet. 2010
20937701 Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors

Yoshimura, S, Gerondopoulos, A, Linford, A, Rigden, DJ, Barr, FA

J. Cell Biol. 2010
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