Interaction of DAP12 and KIR2DS5

Stable Identifier
R-HSA-2272668
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
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Summation

Killer cell immunoglobulin-like two-domain short-tail receptor 5 (KIR2DS5) is an activating KIR receptor expressed on natural killer (NK) cells and subpopulations of T lymphocytes (Nowak et al. 2010). KIR2DS5 has two Ig domains of the D1-D2 type, a short cytoplasmic tail and a positive charged transmembrane (TM) portion.
No physiological ligand has yet been identified for KIR2DS5 but it is able to associate with DAP12 and induce both cytotoxicity and cytokine release when KIR2DS5 is cross-linked with monoclonal antibody (Della Chiesa et al. 2008).

Literature References
PubMed ID Title Journal Year
20865034 Does the KIR2DS5 gene protect from some human diseases?

Nowak, I, Majorczyk, E, Wi?niewski, A, Pawlik, A, Magott-Procelewska, M, Passowicz-Muszy?ska, E, Malejczyk, J, P?oski, R, Giebel, S, Barcz, E, Zo?-Giebel, A, Malinowski, A, Tchórzewski, H, Chlebicki, A, ?uszczek, W, Kurpisz, M, Grybo?, M, Wilczy?ski, J, Wiland, P, Senitzer, D, Sun, JY, Jankowska, R, Klinger, M, Ku?nierczyk, P

PLoS ONE 2010
18624290 Evidence that the KIR2DS5 gene codes for a surface receptor triggering natural killer cell function

Della Chiesa, M, Romeo, E, Falco, M, Balsamo, M, Augugliaro, R, Moretta, L, Bottino, C, Moretta, A, Vitale, M

Eur. J. Immunol. 2008
Participants
Input
Output
Participant Of
hasEvent
Authored
Garapati, P V  (2012-05-25)
Reviewed
Lanier, LL  (2012-08-09)