Interaction of DAP12 and KIR2DS4

Stable Identifier
R-HSA-2272753
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
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Summation

Killer cell immunoglobulin-like two-domain short-tail receptor 4 (KIR2DS4) is the most prevalent lineage III-activating KIR receptor. It interacts weakly but specifically with HLA-Cw3 and HLA-Cw4 and may also bind to an uncharacterised non-MHC molecule. It can associate with DAP12, activating NK cells.

Literature References
PubMed ID Title Journal Year
15265913 MHC class I-independent recognition of NK-activating receptor KIR2DS4

Katz, G, Gazit, R, Arnon, TI, Gonen-Gross, T, Tarcic, G, Markel, G, Gruda, R, Achdout, H, Drize, O, Merims, S, Mandelboim, O

J. Immunol. 2004
19858347 KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C

Graef, T, Moesta, AK, Norman, PJ, Abi-Rached, L, Vago, L, Older Aguilar, AM, Gleimer, M, Hammond, JA, Guethlein, LA, Bushnell, DA, Robinson, PJ, Parham, P

J. Exp. Med. 2009
Participants
Input
Output
Participant Of
hasEvent
Authored
Garapati, P V  (2012-05-25)
Reviewed
Lanier, LL  (2012-08-09)
Created
Garapati, P V  (2012-05-25)