Reactome | Condensin II complex binds H4K20me1-containing nucleosomes

Condensin II complex binds H4K20me1-containing nucleosomes

Stable Identifier

R-HSA-2288097

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Condensin II complex binds H4K20me1-containing nucleosomes

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Accumulation of monomethylated histone H4 (H4K20me1) is necessary for loading of the condensin II complex on chromatin. Condensin II binds H4K20me1 through HEAT repeats of two condensin II subunits, NCAPD3 and NCAPG2 (Liu et al. 2010). RB1 is required, at least partially, for the successful association of condensin II with chromatin (Longworth et al. 2008). The precise role of RB1 in condensin II loading and the connection, if any, between histone H4 monomethylation and RB1-facilitated loading of the condensin II complex on chromatin has not, however, been elucidated. RB1 family proteins are known to interact with H4K20 trimethylating enzymes Suv4-20h1 and Suv4-20h2 and promote H4K20 trimethylation at pericentric and telomeric heterochromatin (Gonzalo et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15750587	Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin Gonzalo, S, García-Cao, M, Fraga, MF, Schotta, G, Peters, AH, Cotter, SE, Eguía, R, Dean, DC, Esteller, M, Jenuwein, T, Blasco, MA	Nat. Cell Biol.	2005
20622854	PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression Liu, W, Tanasa, B, Tyurina, OV, Zhou, TY, Gassmann, R, Liu, WT, Ohgi, KA, Benner, C, Garcia-Bassets, I, Aggarwal, AK, Desai, A, Dorrestein, PC, Glass, CK, Rosenfeld, MG	Nature	2010
18367646	RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3 Longworth, MS, Herr, A, Ji, JY, Dyson, NJ	Genes Dev	2008