Reactome | SETD8 monomethylates histone H4

SETD8 monomethylates histone H4

Stable Identifier

R-HSA-2301205

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

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SETD8 is a protein-lysine N-methyltransferase that monomethylates H4 histone to produce H4K20me1 (Nishioka et al. 2002, Wu et al. 2010). SETD8 levels peak at G2/M transition, and regulated SETD8 activity is required for normal cell cycle progression (Rice et al. 2002, Wu et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20966048	Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression Wu, S, Wang, W, Kong, X, Congdon, LM, Yokomori, K, Kirschner, MW, Rice, JC	Genes Dev.	2010
12086618	PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin Nishioka, K, Rice, JC, Sarma, K, Erdjument-Bromage, H, Werner, J, Wang, Y, Chuikov, S, Valenzuela, P, Tempst, P, Steward, R, Lis, JT, Allis, CD, Reinberg, D	Mol. Cell	2002
12208845	Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes Rice, JC, Nishioka, K, Sarma, K, Steward, R, Reinberg, D, Allis, CD	Genes Dev.	2002