SETD8 is a protein-lysine N-methyltransferase that monomethylates H4 histone to produce H4K20me1 (Nishioka et al. 2002, Wu et al. 2010). SETD8 levels peak at G2/M transition, and regulated SETD8 activity is required for normal cell cycle progression (Rice et al. 2002, Wu et al. 2010).
Wu, S, Wang, W, Kong, X, Congdon, LM, Yokomori, K, Kirschner, MW, Rice, JC
Nishioka, K, Rice, JC, Sarma, K, Erdjument-Bromage, H, Werner, J, Wang, Y, Chuikov, S, Valenzuela, P, Tempst, P, Steward, R, Lis, JT, Allis, CD, Reinberg, D
Rice, JC, Nishioka, K, Sarma, K, Steward, R, Reinberg, D, Allis, CD
© 2020 Reactome
