PTGS2 dimer binds celecoxib

Stable Identifier
R-HSA-2309779
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

While closely similar, PTGS1 and 2 differ sufficiently in the structures of their active sites so that the latter enzyme selectively binds and is inhibited by celecoxib (Luong et al. 1996; Smith et al. 2000; Dong et al. 2011).

Literature References
PubMed ID Title Journal Year
10966456 Cyclooxygenases: structural, cellular, and molecular biology

Smith, WL, DeWitt, DL, Garavito, RM

Annu Rev Biochem 2000
21467029 Human cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimer

Dong, L, Vecchio, AJ, Sharma, NP, Jurban, BJ, Malkowski, MG, Smith, WL

J. Biol. Chem. 2011
8901870 Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2

Luong, C, Miller, A, Barnett, J, Chow, J, Ramesha, C, Browner, MF

Nat. Struct. Biol. 1996
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