Aspirin acetylates PTGS2

Stable Identifier
R-HSA-2314686
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Aspirin (acetylsalicylate) reacts spontaneously with one subunit of PTGS2 dimer (Dong et al. 2011) to acetylate serine residue 516 (Lecomte et al. 1994). The modified enzyme is no longer capable of catalyzing the conversion of arachidonic acid to PGH2, but acquires the ability to convert it to 15R-HETE.

Literature References
PubMed ID Title Journal Year
8175750 Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin

Lecomte, M, Laneuville, O, Ji, C, DeWitt, DL, Smith, WL

J. Biol. Chem. 1994
21467029 Human cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimer

Dong, L, Vecchio, AJ, Sharma, NP, Jurban, BJ, Malkowski, MG, Smith, WL

J. Biol. Chem. 2011
Participants
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