RAB4A:GTP binds KIF3 and activates KIF3

Stable Identifier
R-HSA-2316347
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytoplasmic vesicle membrane, cytosol
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RAB4A:GTP binds KIF3 and activates KIF3
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As inferred from mouse adipocytes, insulin signals via PKC-lambda to cause Rab4 to load GTP and associate with Kif3, which then has higher affinity for microtubules. Motor activity of Kif3 along microtubules is believed to transport vesicles containing Glut4 (Slc2a4) across the cytosol to the cortical actin network.

Participants
Input
Output
Participant Of
hasEvent
Inferred From
Rab4a:GTP Activates Kif3 (Mus musculus)
Authored
May, B  (2012-05-27)
Reviewed
Klip, A  (2012-08-21)
Created
May, B  (2012-06-08)