RALA:GTP binds MYO1C:CALM1 and activates MYO1C

Stable Identifier
R-HSA-2316349
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytoplasmic vesicle membrane, cytosol
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RALA:GTP binds MYO1C:CALM1 and activates MYO1C
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As inferred from mouse, insulin causes phosphorylation and inactivation of the Ral GTPase activating complex RGC, causing RALA:GTP to accumulate and associate with the unconventional myosin MYO1C. MYO1C, with calmodulin as a light chain, motors across cortical actin and interacts with the exocyst complex to tether vesicles at the plasma membrane (Chen et al. 2007).

Participants
Input
Output
Participant Of
hasEvent
Inferred From
RalA:GTP binds Myo1c:Calm1 and F-actin (Mus musculus)
Authored
May, B  (2012-05-27)
Reviewed
Klip, A  (2012-08-21)
Created
May, B  (2012-06-08)