Reactome | GGC-PalmC-RAC1 [plasma membrane]

GGC-PalmC-RAC1 [plasma membrane]

Stable Identifier

R-HSA-2316446

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

RAC1, Ras-related C3 botulinum toxin substrate 1, RAC1_HUMAN

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Literature References

PubMed ID	Title	Journal	Year
1903399	Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA Kinsella, BT, Erdman, RA, Maltese, WA	J. Biol. Chem.	1991
22157745	A palmitoylation switch mechanism regulates Rac1 function and membrane organization Navarro-Lérida, I, Sánchez-Perales, S, Calvo, M, Rentero, C, Zheng, Y, Enrich, C, Del Pozo, MA	EMBO J.	2012

External Reference Information

External Reference

UniProt:P63000 RAC1

Gene Names

RAC1, TC25, MIG5

Chain

chain:1-189, propeptide:190-192

Reference Genes

BioGPS Gene:5879 RAC1

COSMIC (genes):RAC1 RAC1

CTD Gene:5879 RAC1

dbSNP Gene:5879 RAC1

ENSEMBL:ENSG00000136238 RAC1

HGNC:9801 RAC1

KEGG Gene (Homo sapiens):5879 RAC1

Monarch:5879 RAC1

NCBI Gene:5879 RAC1

OMIM:602048 RAC1

UCSC:P63000 RAC1

Reference Transcript

Other Identifiers

0002850037

0004060369

11715576_at

11715577_x_at

11715578_s_at

11725303_a_at

11725304_s_at

11753603_s_at

1567458_3p_s_at

1567458_s_at

17043405

1E96

1FOE

1G4U

1HE1

1HH4

1I4D

1I4L

1I4T

1MH1

1RYF

1RYH

2050_s_at

208640_at

208641_s_at

2768033

2768035

2768036

2768037

2768038

2780942

2989052

2989053

2989054

2989055

2989057

2989061

2989062

2989068

2989070

2989073

2989076

2989077

2989078

2989079

2FJU

2H7V

2NZ8

2P2L

2RMK

2VRW

2WKP

2WKQ

2WKR

2YIN

35994

3B13

3BJI

3RYT

3SBD

3SBE

3SU8

3SUA

3TH5

40864_at

47820

4GZL

4GZM

4YON

5879

5FI0

5HZH

5N6O

5O33

6BC1

8131406

8180341

8180342

8180343

A4D2P0

A4D2P1

A_23_P215406

A_32_P217709

AAA36537

AAA36544

AAD30547

AAH04247

AAH50687

AAI07749

AAM21111

AAP35785

AAQ16632

AAS07511

AAS07512

AAZ80485

AB451238

AB451363

AC009412

AF136373

AF498964

AJ132694

AJ132695

AK054993

AK291806

AK291815

AY279384

BAF84495

BAF84504

BAG51447

BAG70052

BAG70177

BC004247

BC050687

BC107748

BT007121

CAA10732

CAA10733

CAB035994

CAB53579

CCDS5348

CCDS5349

CH236963

CH878731

D25274_at

DQ165078

EAL23718

EAL23719

EAW55039

EAW55044

ENSG00000136238

ENSP00000258737

ENSP00000348461

ENST00000348035

ENST00000348035.8

ENST00000356142

ENST00000356142.4

EntrezGene:5879

EntrezGene:RAC1

g13279010_3p_a_at

GE57124

GE79176

GO:0000139

GO:0000166

GO:0000902

GO:0001764

GO:0001934

GO:0002376

GO:0002551

GO:0003674

GO:0003924

GO:0005515

GO:0005525

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005737

GO:0005768

GO:0005783

GO:0005789

GO:0005794

GO:0005802

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005925

GO:0006464

GO:0006810

GO:0006935

GO:0006950

GO:0006954

GO:0007010

GO:0007015

GO:0007155

GO:0007160

GO:0007165

GO:0007264

GO:0007266

GO:0007267

GO:0007596

GO:0008045

GO:0008150

GO:0008283

GO:0008361

GO:0009058

GO:0009611

GO:0009653

GO:0010310

GO:0010591

GO:0010592

GO:0010811

GO:0016020

GO:0016192

GO:0016477

GO:0016601

GO:0017137

GO:0019899

GO:0019901

GO:0022607

GO:0030027

GO:0030031

GO:0030032

GO:0030036

GO:0030041

GO:0030154

GO:0030334

GO:0030667

GO:0031116

GO:0031295

GO:0031410

GO:0031529

GO:0031996

GO:0032587

GO:0032707

GO:0032991

GO:0034330

GO:0034446

GO:0034641

GO:0035025

GO:0035556

GO:0035774

GO:0036464

GO:0038095

GO:0038096

GO:0040011

GO:0042470

GO:0042592

GO:0042826

GO:0042995

GO:0043167

GO:0043197

GO:0043226

GO:0043312

GO:0044403

GO:0044877

GO:0045428

GO:0045453

GO:0045740

GO:0048010

GO:0048012

GO:0048013

GO:0048261

GO:0048856

GO:0048870

GO:0050690

GO:0051022

GO:0051056

GO:0051117

GO:0051186

GO:0051492

GO:0051496

GO:0051668

GO:0051894

GO:0051897

GO:0055038

GO:0060071

GO:0060263

GO:0065003

GO:0070062

GO:0071260

GO:0071526

GO:0090023

GO:0097178

GO:0098794

GO:0098978

GO:0101003

GO:1900026

GO:1902622

HGNC:9801

HPA047820

Hs.173737.0.A2_3p_at

Hs2.413489.1.S1_3p_s_at

ILMN_1652445

ILMN_2359789

IPR001806

IPR003578

IPR005225

IPR027417

M29870

M31467

MIM:602048

MIM:617751

NM_006908

NM_018890

NP_008839

NP_061485

PF00071

PH_hs_0033233

PR00449

RAC1

RAC1-201

RAC1-202

SM00173

SM00174

SM00175

TC04001163.hg

TC07000065.hg

UPI000000060F

UPI000002B20E

Participant Of

hasComponent

Other forms of this molecule

RAC1 [endoplasmic reticulum membrane]

RAC1 [ficolin-1-rich granule membrane]

RAC1 [secretory granule membrane]

RAC1 [cytosol]

RAC1 [plasma membrane]

Inferred To

GGC-PalmC-RAC1 [plasma membrane] (Bos taurus)

GGC-PalmC-RAC1 [plasma membrane] (Caenorhabditis elegans)

GGC-PalmC-RAC1 [plasma membrane] (Danio rerio)

GGC-PalmC-RAC1 [plasma membrane] (Dictyostelium discoideum)

GGC-PalmC-RAC1 [plasma membrane] (Drosophila melanogaster)

GGC-PalmC-RAC1 [plasma membrane] (Gallus gallus)

GGC-PalmC-RAC1 [plasma membrane] (Mus musculus)

GGC-PalmC-RAC1 [plasma membrane] (Rattus norvegicus)

GGC-PalmC-RAC1 [plasma membrane] (Sus scrofa)

GGC-PalmC-RAC1 [plasma membrane] (Xenopus tropicalis)

Ghost homologue of GGC-PalmC-RAC1 [plasma membrane] (Canis familiaris)

Modified Residues

Name

S-palmitoyl-L-cysteine at 178

Coordinate

178

PsiMod Name

S-palmitoyl-L-cysteine [MOD:00115]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.

Name

S-geranylgeranyl-L-cysteine at 189

Coordinate

189

PsiMod Name

S-geranylgeranyl-L-cysteine [MOD:00113]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.

Cross References

RefSeq

NP_008839.2, NP_061485.1

OpenTargets

ENSG00000136238

IntEnz

3.6.5.2

ZINC - Substances

RAC1_HUMAN

GeneCards

P63000

ZINC - Biogenic

RAC1_HUMAN

ZINC target

P63000

PRO

P63000

Orphanet

24845

ZINC - Predictions - Purchasable

RAC1_HUMAN

HMDB Protein

HMDBP01778

PDB

2FJU, 2H7V, 3SBD, 3SU8, 6AGP, 3SBE, 3TH5, 2P2L, 4YON, 2VRW, 1MH1, 3B13, 2RMK, 1I4D, 1G4U, 1RYF, 1FOE, 3SUA, 6BC1, 5HZH, 4GZM, 1RYH, 5FI0, 1E96, 2YIN, 4GZL, 2NZ8, 1HE1, 2WKR, 1I4L, 3RYT, 1HH4, 5O33, 2WKQ, 5N6O, 3BJI, 2WKP, 1I4T

Interactors (54)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13153 PAK1	6	p-S144-PAK1 [cytosol] (R-HSA-451339) Active PAK1 [cytosol] (R-HSA-8964622) PAK1 [plasma membrane] (R-HSA-3928409) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) PAK1 [cytosol] (R-HSA-162629) p-S144,T423-PAK1 [cytosol] (R-HSA-399819)	0.976	27
UniProt:P52565 ARHGDIA	1	ARHGDIA [cytosol] (R-HSA-194478)	0.919	9
UniProt:P53365 ARFIP2	1	ARFIP2 [cytosol] (R-HSA-6813848)	0.913	13
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2(1-524) [plasma membrane] (R-HSA-164946) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524)	0.78	4
UniProt:P46940 IQGAP1	3	IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [plasma membrane] (R-HSA-381681)	0.78	5
UniProt:Q14185 DOCK1	1	DOCK1 [cytosol] (R-HSA-372654)	0.734	10
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.728	4
UniProt:Q01105 SET	1	SET [nucleoplasm] (R-HSA-451201)	0.684	8
UniProt:Q14155 ARHGEF7	1	ARHGEF7 [cytosol] (R-HSA-430346)	0.676	8
UniProt:P19878 NCF2	2	p-T233-NCF2 [phagolysosome] (R-HSA-1996211) NCF2 [cytosol] (R-HSA-1222600)	0.658	3
UniProt:P19174 PLCG1	6	p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.639	7
UniProt:Q98PK8 Q98PK8			0.628	5
UniProt:P52757 CHN2	1	CHN2 [cytosol] (R-HSA-2980572)	0.61	4
GTP [ChEBI:15996]	13	GTP [early endosome membrane] (R-ALL-2130170) GTP [cilium] (R-ALL-5617813) GTP [lysosomal membrane] (R-ALL-2213216) GTP [platelet dense granule lumen] (R-ALL-114625) GTP [cytoplasmic vesicle membrane] (R-ALL-1996291) GTP [extracellular region] (R-ALL-114626) GTP [Golgi lumen] (R-ALL-8851242) GTP [endocytic vesicle lumen] (R-ALL-8851508) GTP [ER to Golgi transport vesicle membrane] (R-ALL-983318) GTP [mitochondrial matrix] (R-ALL-113573) GTP [Golgi membrane] (R-ALL-1806221) GTP [nucleoplasm] (R-ALL-113571) GTP [cytosol] (R-ALL-29438)	0.609	2
UniProt:Q7Z6J0 SH3RF1	1	SH3RF1 [cytosol] (R-HSA-5688968)	0.592	2
UniProt:P98170 XIAP	3	K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366) XIAP [cytosol] (R-HSA-50849)	0.591	3
UniProt:Q92608 DOCK2	3	DOCK2 [extracellular region] (R-HSA-6806310) DOCK2 [specific granule lumen] (R-HSA-6799558) DOCK2 [cytosol] (R-HSA-200938)	0.589	3
UniProt:Q92619 ARHGAP45	4	HMHA1 [secretory granule lumen] (R-HSA-6800902) HMHA1 [cytosol] (R-HSA-200621) HMHA1 [extracellular region] (R-HSA-6806219) HMHA1 [azurophil granule lumen] (R-HSA-6799228)	0.571	3
UniProt:Q9BYG5 PARD6B	2	PARD6B [cytosol] (R-HSA-419973) PARD6B [plasma membrane] (R-HSA-418193)	0.567	3
UniProt:Q92556 ELMO1	1	ELMO1 [cytosol] (R-HSA-200932)	0.564	4
UniProt:P15498 VAV1	5	p-Y142,Y160,Y174-VAV1 [plasma membrane] (R-HSA-389323) p-Y-VAV1 [cytosol] (R-HSA-9029087) VAV1 [cytosol] (R-HSA-195066) p-Y174-VAV1 [cytosol] (R-HSA-437946) VAV1 [plasma membrane] (R-HSA-1045153)	0.558	2
UniProt:Q01968 OCRL	4	OCRL [cytoplasmic vesicle membrane] (R-HSA-434214) OCRL [Golgi membrane] (R-HSA-434339) OCRL [plasma membrane] (R-HSA-3769049) OCRL [cytosol] (R-HSA-1806196)	0.556	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.556	5
UniProt:Q9Y6N9 USH1C			0.556	3
UniProt:Q9UJX2 CDC23	2	CDC23 [cytosol] (R-HSA-174137) CDC23 [nucleoplasm] (R-HSA-174228)	0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:P41743 PRKCI	3	PRKCI [cytosol] (R-HSA-58206) PRKCI [nucleoplasm] (R-HSA-9021345) PRKCI [plasma membrane] (R-HSA-420005)	0.548	3
UniProt:Q53QZ3 ARHGAP15	1	ARHGAP15 [cytosol] (R-HSA-195145)	0.544	2
UniProt:Q8TEJ3 SH3R3			0.544	6
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P48039 MTNR1A	1	MTNR1A [plasma membrane] (R-HSA-419316)	0.527	2
UniProt:Q13490 BIRC2	5	BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(373-618) [cytosol] (R-HSA-202931) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2 [cytosol] (R-HSA-50847)	0.525	2
UniProt:Q6P589 TNFAIP8L2	1	TNFAIP8L2 [cytosol] (R-HSA-8874472)	0.524	2
UniProt:O75914 PAK3	3	p-S154,T436-PAK3 [cytosol] (R-HSA-5357471) p-S154,T436-PAK3 [plasma membrane] (R-HSA-3928479) PAK3 [cytosol] (R-HSA-428457)	0.524	2
UniProt:P09669 COX6C	1	COX6C(3-75) [mitochondrial inner membrane] (R-HSA-164298)	0.508	2
UniProt:Q13576 IQGAP2	3	IQGAP2 [plasma membrane] (R-HSA-6804811) IQGAP2 [cytosol] (R-HSA-5625975) IQGAP2 [secretory granule membrane] (R-HSA-6804779)	0.508	2
UniProt:Q9BYG4 PARD6G	2	PARD6G [cytosol] (R-HSA-419967) PARD6G [plasma membrane] (R-HSA-418192)	0.508	2
UniProt:P42704 LRPPRC	1	LRPPRC [mitochondrial matrix] (R-HSA-5336174)	0.508	2
UniProt:P60660 MYL6	2	MYL6 [cytosol] (R-HSA-419186) p-S20-MYL6 [cytosol] (R-HSA-445778)	0.508	2
UniProt:Q86VI3 IQGAP3	1	IQGAP3 [cytosol] (R-HSA-5625977)	0.508	2
UniProt:P14649 MYL6B	2	p-S20-MYL6B [cytosol] (R-HSA-445763) MYL6B [cytosol] (R-HSA-445776)	0.508	2
UniProt:Q9NPB6 PARD6A	4	p-S345-PARD6A [plasma membrane] (R-HSA-2134533) PARD6A [cell junction] (R-HSA-2134480) PARD6A [plasma membrane] (R-HSA-418187) PARD6A [cytosol] (R-HSA-420001)	0.508	2
UniProt:P62158 CALM			0.508	2
UniProt:P27105 STOM	4	STOM [azurophil granule membrane] (R-HSA-6800997) STOM [tertiary granule membrane] (R-HSA-6800960) STOM [plasma membrane] (R-HSA-6806258) STOM [specific granule membrane] (R-HSA-6799569)	0.508	2
UniProt:Q9H9P5 UNKL	1	UNKL [cytosol] (R-HSA-8850900)	0.508	2
UniProt:Q03135 CAV1	5	CAV1 [early endosome membrane] (R-HSA-5368451) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009)	0.499	2
UniProt:O75369 FLNB	1	FLNB [cytosol] (R-HSA-354163)	0.499	2
UniProt:Q99750 MDFI			0.488	2
UniProt:Q8N9S9-2 SNX31			0.488	2
UniProt:Q8WUI4-6 HDAC7			0.488	2
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]	7	PI(3,5)P2 [plasma membrane] (R-ALL-1806224) PI(3,5)P2 [phagophore assembly site membrane] (R-ALL-5692959) PI(3,5)P2 [Golgi membrane] (R-ALL-1806290) PI(3,5)P2 [early endosome membrane] (R-ALL-1806205) PI(3,5)P2 [late endosome membrane] (R-ALL-1806289) PI(3,5)P2 [endoplasmic reticulum membrane] (R-ALL-6809774) PI(3,5)P2 [lysosomal membrane] (R-ALL-5334668)	0.462	2
UniProt:P27986 PIK3R1	15	PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.462	5
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]	6	PI(4,5)P2 [Golgi membrane] (R-ALL-1806165) PI(4,5)P2 [plasma membrane] (R-ALL-179856) PI(4,5)P2 [endoplasmic reticulum membrane] (R-ALL-2023856) PI(4,5)P2 [nucleoplasm] (R-ALL-6810412) PI(4,5)P2 [cytoplasmic vesicle membrane] (R-ALL-8874467) PI(4,5)P2 [early endosome membrane] (R-ALL-8849966)	0.462	2