GGC-PalmC-RAC1 [plasma membrane]

Stable Identifier
R-HSA-2316446
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
RAC1, Ras-related C3 botulinum toxin substrate 1, RAC1_HUMAN
GGC-PalmC-RAC1 [plasma membrane] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
1903399 Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA

Kinsella, BT, Erdman, RA, Maltese, WA

J. Biol. Chem. 1991
22157745 A palmitoylation switch mechanism regulates Rac1 function and membrane organization

Navarro-Lérida, I, Sánchez-Perales, S, Calvo, M, Rentero, C, Zheng, Y, Enrich, C, Del Pozo, MA

EMBO J. 2012
External Reference Information
External Reference
Gene Names
RAC1, TC25, MIG5
Chain
chain:1-189, propeptide:190-192
Other Identifiers
0002850037
0004060369
11715576_at
11715577_x_at
11715578_s_at
11725303_a_at
11725304_s_at
11753603_s_at
1567458_3p_s_at
1567458_s_at
17043405
2050_s_at
208640_at
208641_s_at
2768033
2768035
2768036
2768037
2768038
2780942
2989052
2989053
2989054
2989055
2989057
2989061
2989062
2989068
2989070
2989073
2989076
2989077
2989078
2989079
40864_at
5879
8131406
8180341
8180342
8180343
A_23_P215406
A_32_P217709
D25274_at
GE57124
GE79176
GO:0000139
GO:0000166
GO:0000902
GO:0001764
GO:0001934
GO:0002376
GO:0002551
GO:0003674
GO:0003924
GO:0005515
GO:0005525
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005768
GO:0005789
GO:0005794
GO:0005802
GO:0005829
GO:0005856
GO:0005884
GO:0005886
GO:0005925
GO:0005938
GO:0006464
GO:0006810
GO:0006935
GO:0006950
GO:0006954
GO:0007010
GO:0007015
GO:0007155
GO:0007160
GO:0007163
GO:0007165
GO:0007264
GO:0007266
GO:0007267
GO:0007596
GO:0008045
GO:0008150
GO:0008283
GO:0008360
GO:0008361
GO:0009058
GO:0009611
GO:0009653
GO:0010310
GO:0010591
GO:0010592
GO:0010811
GO:0015031
GO:0016020
GO:0016192
GO:0016601
GO:0016787
GO:0017137
GO:0019899
GO:0019901
GO:0022607
GO:0030027
GO:0030031
GO:0030032
GO:0030036
GO:0030041
GO:0030154
GO:0030334
GO:0030667
GO:0030865
GO:0031116
GO:0031295
GO:0031410
GO:0031529
GO:0031996
GO:0032587
GO:0032707
GO:0032956
GO:0034330
GO:0034446
GO:0034641
GO:0035025
GO:0035556
GO:0035774
GO:0036464
GO:0038095
GO:0038096
GO:0040011
GO:0042470
GO:0042592
GO:0042826
GO:0042995
GO:0043167
GO:0043197
GO:0043226
GO:0043231
GO:0043312
GO:0043652
GO:0044403
GO:0044877
GO:0045428
GO:0045453
GO:0045740
GO:0048010
GO:0048012
GO:0048013
GO:0048261
GO:0048856
GO:0048870
GO:0050690
GO:0051022
GO:0051056
GO:0051117
GO:0051186
GO:0051492
GO:0051496
GO:0051668
GO:0051894
GO:0051897
GO:0055038
GO:0060071
GO:0060263
GO:0061024
GO:0065003
GO:0070062
GO:0071260
GO:0071526
GO:0090023
GO:0097178
GO:0098794
GO:0098978
GO:0101003
GO:1900026
GO:1902622
Hs.173737.0.A2_3p_at
Hs2.413489.1.S1_3p_s_at
ILMN_1652445
ILMN_2359789
PH_hs_0033233
TC04001163.hg
TC07000065.hg
g13279010_3p_a_at
Participant Of
Other forms of this molecule
Inferred To
Modified Residues
Name
S-palmitoyl-L-cysteine at 178
Coordinate
178
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.
Name
S-geranylgeranyl-L-cysteine at 189
Coordinate
189
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.
Cross References
OpenTargets
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
GeneCards
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (56)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q13153 PAK1  6 0.976 27
 UniProt:P52565 ARHGDIA  1 0.927 11
 UniProt:P53365 ARFIP2  1 0.913 13
 UniProt:P46940 IQGAP1  3 0.893 11
 UniProt:Q13177 PAK2  11 0.78 4
 UniProt:Q14185 DOCK1  1 0.734 10
 UniProt:Q9UQB8 BAIAP2  1 0.728 4
 UniProt:Q01105 SET  1 0.684 8
 UniProt:Q14155 ARHGEF7  1 0.676 8
 UniProt:P19878 NCF2  2 0.658 3
 UniProt:P19174 PLCG1  6 0.639 7
 UniProt:Q98PK8 Q98PK8      0.628 5
 UniProt:P52757 CHN2  1 0.61 4
 GTP [ChEBI:15996]  13 0.609 2
 UniProt:Q8WUI4-6 HDAC7      0.601 4
 UniProt:Q7Z6J0 SH3RF1  1 0.592 2
 UniProt:P98170 XIAP  3 0.591 3
 UniProt:Q92608 DOCK2  3 0.589 3
 UniProt:Q92619 ARHGAP45  4 0.571 3
 UniProt:Q9BYG5 PARD6B  2 0.567 3
 UniProt:Q92556 ELMO1  1 0.564 4
 UniProt:P15498 VAV1  5 0.558 2
 UniProt:Q99750 MDFI      0.556 3
 UniProt:Q01968 OCRL  4 0.556 3
 UniProt:Q9Y6N9 USH1C      0.556 3
 UniProt:Q9UJX2 CDC23  2 0.556 3
 UniProt:Q6A162 KRT40  1 0.556 3
 UniProt:Q9BRK4 LZTS2      0.556 3
 UniProt:Q5S007 LRRK2  1 0.556 5
 UniProt:P41743 PRKCI  3 0.548 3
 UniProt:P52306 GDS1      0.547 2
 UniProt:P0CG48 UBC  325 0.547 2
 UniProt:Q53QZ3 ARHGAP15  1 0.544 2
 UniProt:Q8TEJ3 SH3R3      0.544 6
 UniProt:P48039 MTNR1A  1 0.527 2
 UniProt:P19320 VCAM1  1 0.527 4
 UniProt:Q13490 BIRC2  5 0.525 2
 UniProt:Q6P589 TNFAIP8L2  1 0.524 2
 UniProt:O75914 PAK3  3 0.524 2
 UniProt:P09669 COX6C  1 0.508 2
 UniProt:Q13576 IQGAP2  3 0.508 2
 UniProt:Q9BYG4 PARD6G  2 0.508 2
 UniProt:P42704 LRPPRC  1 0.508 2
 UniProt:P60660 MYL6  2 0.508 2
 UniProt:Q86VI3 IQGAP3  1 0.508 2
 UniProt:P14649 MYL6B  2 0.508 2
 UniProt:Q9NPB6 PARD6A  4 0.508 2
 UniProt:P27105 STOM  4 0.508 2
 UniProt:Q9H9P5 UNKL  1 0.508 2
 UniProt:P0DP23 CALM1  5 0.508 2
 UniProt:O75369 FLNB  1 0.499 2
 UniProt:Q03135 CAV1  5 0.499 2
 UniProt:Q8N9S9-2 SNX31      0.488 2
 UniProt:P27986 PIK3R1  15 0.462 5
 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]  7 0.462 2
 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]  6 0.462 2
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