Reactome | LAMA4 [extracellular region]

LAMA4 [extracellular region]

Stable Identifier

R-HSA-2328105

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Laminin alpha-4 chain, LAMA4_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by MET (Homo sapiens)
    - MET promotes cell motility (Homo sapiens)
      - MET activates PTK2 signaling (Homo sapiens)
        
        PTK2 binds activated MET (Homo sapiens)
        
        Integrin alpha2beta1,alpha3:beta1:(collagen,laminin,fibronectin) [plasma membrane] (Homo sapiens)
        
        Collagen, laminin, fibronectin [extracellular region] (Homo sapiens)
        
        Laminins [extracellular region] (Homo sapiens)
        
        Laminin-411 [extracellular region] (Homo sapiens)
        
        LAMA4 [extracellular region] (Homo sapiens)
        
        Laminin-421 [extracellular region] (Homo sapiens)
        
        LAMA4 [extracellular region] (Homo sapiens)
        
        Laminin-423 [extracellular region] (Homo sapiens)
        
        LAMA4 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16363 LAMA4

Gene Names

LAMA4

Chain

signal peptide:1-24, chain:25-1823

Reference Genes

BioGPS Gene:3910 LAMA4

COSMIC (genes):LAMA4 LAMA4

CTD Gene:3910 LAMA4

dbSNP Gene:3910 LAMA4

ENSEMBL:ENSG00000112769 LAMA4

ENSEMBL_homo_sapiens_GENE:ENSG00000112769.20 LAMA4

HGNC:6484 LAMA4

KEGG Gene (Homo sapiens):3910 LAMA4

Monarch:3910 LAMA4

NCBI Gene:3910 LAMA4

OMIM:600133 LAMA4

UCSC:Q16363 LAMA4

Reference Transcript

Other Identifiers

11722282_a_at

210089_PM_s_at

210089_s_at

2970195

2970196

2970197

2970198

2970199

2970200

2970201

2970203

2970204

3910

A_33_P3391603

GO:0005102

GO:0005198

GO:0005201

GO:0005515

GO:0005576

GO:0005604

GO:0005615

GO:0007155

GO:0030155

GO:0030312

GO:0030334

GO:0031012

GO:0043226

GO:0045995

GO:0048856

GO:0048870

GO:0062023

GO:0070062

GO:0120163

HMNXSV003005884

g13278992_3p_at

Participates

as a component of

Inferred To

LAMA4 [extracellular region] (Bos taurus)

LAMA4 [extracellular region] (Canis familiaris)

LAMA4 [extracellular region] (Sus scrofa)

Lama4 [extracellular region] (Mus musculus)

Lama4 [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_002281.3, XP_005267041.2, NP_001098679.1, NP_001098676.2, NP_001098677.2, XP_005267040.2, NP_001098678.1

OpenTargets

ENSG00000112769

GeneCards

Q16363

HPA

ENSG00000112769-LAMA4

Ensembl

ENSP00000408604, ENST00000453937, ENSP00000398226, ENSG00000112769, ENST00000368638, ENST00000455073, ENSP00000357627

PRO

Q16363

Pharos - Targets

Q16363

Orphanet

22041

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.519	2