Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP

Stable Identifier
R-HSA-2393954
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
ADP-ribose + H2O => AMP + D-ribose 5-phosphate (mitochondrial)
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Mitochondrial NUDT9 (ADP-ribose pyrophosphatase) catalyzes the hydrolysis of ADP-ribose to form AMP and D-ribose 5-phosphate. The active enzyme is the longer of two isoforms generated by alternative splicing and is a monomer complexed with two magnesium ions (Perraud et al. 2003; Shen et al. 2003).

Literature References
PubMed ID Title Journal Year
12948489 The crystal structure and mutational analysis of human NUDT9

Shen, BW, Perraud, AL, Scharenberg, AM, Stoddard, BL

J. Mol. Biol. 2003
12427752 NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase

Perraud, AL, Shen, BW, Dunn, CA, Rippe, K, Smith, MK, Bessman, MJ, Stoddard, BL, Scharenberg, AM

J. Biol. Chem. 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ADP-ribose diphosphatase activity of NUDT9 [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created