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Formation of dehydro-hydroxylysino-norleucine cross-links
Stable Identifier
R-HSA-2395257
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Extracellular matrix organization (Homo sapiens)
Collagen formation (Homo sapiens)
Assembly of collagen fibrils and other multimeric structures (Homo sapiens)
Crosslinking of collagen fibrils (Homo sapiens)
Formation of dehydro-hydroxylysino-norleucine cross-links (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Allysine residues condense with hydroxylysine residues to form the aldimine dehydro-hydroxylysino-norleucine (deH-HLNL), first identified by Bailey & Peach (1968).
Literature References
PubMed ID
Title
Journal
Year
5723342
Isolation and structural identification of a labile intermolecular crosslink in collagen
Peach, CM
,
Bailey, AJ
Biochem Biophys Res Commun
1968
Participants
Input
Collagen type I fibril [extracellular region]
(Homo sapiens)
Collagen type I fibril with allysines [extracellular region]
(Homo sapiens)
Output
Collagen type I fibrils with deH-HLNL cross-links [extracellular region]
(Homo sapiens)
Participates
as an event of
Crosslinking of collagen fibrils (Homo sapiens)
Orthologous Events
Formation of dehydro-hydroxylysino-norleucine cross-links (Bos taurus)
Formation of dehydro-hydroxylysino-norleucine cross-links (Caenorhabditis elegans)
Formation of dehydro-hydroxylysino-norleucine cross-links (Canis familiaris)
Formation of dehydro-hydroxylysino-norleucine cross-links (Danio rerio)
Formation of dehydro-hydroxylysino-norleucine cross-links (Gallus gallus)
Formation of dehydro-hydroxylysino-norleucine cross-links (Mus musculus)
Formation of dehydro-hydroxylysino-norleucine cross-links (Rattus norvegicus)
Formation of dehydro-hydroxylysino-norleucine cross-links (Sus scrofa)
Formation of dehydro-hydroxylysino-norleucine cross-links (Xenopus tropicalis)
Authored
Jupe, S (2012-04-30)
Reviewed
Raleigh, S (2012-10-08)
Ricard-Blum, S (2012-11-19)
Kalamajski, S (2012-10-08)
Created
Jupe, S (2012-06-29)
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