Formation of hydroxylysino-5-ketonorleucine cross-links

Stable Identifier
R-HSA-2395302
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Hydroxyallysine and hydroxylysine can react forming the Schiff base, which spontaneously undergoes an Amadori rearrangement resulting in the ketoimine cross-link hydroxylysino-5-ketonorleucine (HLKNL). This is much more stable than the aldimine crosslinks (Bailey et al. 1998).

Literature References
PubMed ID Title Journal Year
3992061 Skeletal muscle injury--molecular changes in the collagen during healing

Lehto, M, Sims, TJ, Bailey, AJ

Res Exp Med (Berl) 1985
1348714 Enzymatic and nonenzymatic cross-linking of collagen and elastin

Reiser, K, McCormick, RJ, Rucker, RB

FASEB J. 1992
Participants
Participant Of
Orthologous Events
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