Formation of hydroxylysino-5-ketonorleucine cross-links

Stable Identifier
R-HSA-2395302
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Hydroxyallysine and hydroxylysine can react forming the Schiff base, which spontaneously undergoes an Amadori rearrangement resulting in the ketoimine cross-link hydroxylysino-5-ketonorleucine (HLKNL). This is much more stable than the aldimine crosslinks (Bailey et al. 1998).

Literature References
PubMed ID Title Journal Year
3992061 Skeletal muscle injury--molecular changes in the collagen during healing

Lehto, M, Sims, TJ, Bailey, AJ

Res Exp Med (Berl) 1985
1348714 Enzymatic and nonenzymatic cross-linking of collagen and elastin

Reiser, K, McCormick, RJ, Rucker, RB

FASEB J. 1992
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created