Formation of lysino-5-ketonorleucine cross-links

Stable Identifier
R-HSA-2395314
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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In bone, cross-links are formed between telopeptide hydroxallysine residues and helical lysines (Robins & Bailey 1975). The resulting Schiff base undergoes Amadori rearrangement to form lysino-5-ketonorleucine (LKNL).

Literature References
PubMed ID Title Journal Year
  Dynamics of Bone and Cartilage Metabolism

Seibel, MJ, Robins, SP, Bilezikian, JP

  2006
1237296 The chemistry of the collagen cross-links. The mechanism of stabilization of the reducible intermediate cross-links

Robins, SP, Bailey, AJ

Biochem. J. 1975
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