Reactome: A Curated Pathway Database

Formation of lysino-5-ketonorleucine cross-links

Stable Identifier
R-HSA-2395314
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

In bone, cross-links are formed between telopeptide hydroxallysine residues and helical lysines (Robins & Bailey 1975). The resulting Schiff base undergoes Amadori rearrangement to form lysino-5-ketonorleucine (LKNL).

Literature References
PubMed ID Title Journal Year
  Dynamics of Bone and Cartilage Metabolism   2006
1237296 The chemistry of the collagen cross-links. The mechanism of stabilization of the reducible intermediate cross-links Biochem. J. 1975
Participants
Participant Of
Orthologous Events