Formation of hydroxylysyl-pyrrole cross-links

Stable Identifier
R-HSA-2395324
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

Trivalent collagen cross-links can form as pyrroles. Hydroxylysyl-Pyrrole (HL-Pyrrole) is formed when Hydroxylysino-ketonorleucine (HLKNL) reacts with hydroxylysino-norleucine (deH-HLNL) (Eyre et al. 2008). The mechanism of pyrrole cross-links has been revised to a structure based on 3-hydroxypyrrole, rather than a pyrrole lacking a hydroxyl on the ring as depicted earlier (Bailey et al. 1998).

Literature References
PubMed ID Title Journal Year
12211432 Mechanical properties of adult vertebral cancellous bone: correlation with collagen intermolecular cross-links

Banse, X, Sims, TJ, Bailey, AJ

J. Bone Miner. Res. 2002
A collagen-associated Ehrlich chromogen: a pyrrolic cross-link?

Scott, JE, Hughes, EW, Shuttleworth, A

Bioscience Reports 1981
1567360 Identification of the loci of the collagen-associated Ehrlich chromogen in type I collagen confirms its role as a trivalent cross-link

Kuypers, R, Tyler, M, Kurth, LB, Jenkins, ID, Horgan, DJ

Biochem J 1992
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