Formation of hydroxyallysine by LOX

Stable Identifier
R-HSA-2395340
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Formation of hydroxyallysine by LOX
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Hydroxylysines residues can be converted to hydroxyallysines by lysyl oxidase. In this representative reaction a single hydroxylysine residue in each collagen chain is shown as converted to hydroxyallysine (Pinnell et al. 1968, Siegel 1979).
Literature References
PubMed ID Title Journal Year
5246001 The cross-linking of collagen and elastin: enzymatic conversion of lysine in peptide linkage to alpha-aminoadipic-delta-semialdehyde (allysine) by an extract from bone

Martin, GR, Pinnell, SR

Proc Natl Acad Sci U S A 1968
41816 Lysyl oxidase

Siegel, RC

Int Rev Connect Tissue Res 1979
Participants
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Output
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as an event of
Catalyst Activity

protein-lysine 6-oxidase activity of Lysyl oxidases:Cu2+ [extracellular region]

Physical Entity
Lysyl oxidases:Cu2+ [extracellular region] (Homo sapiens)
Activity
protein-lysine 6-oxidase activity (GO:0004720)
Orthologous Events
Formation of hydroxyallysine by LOX (Bos taurus)
Formation of hydroxyallysine by LOX (Canis familiaris)
Formation of hydroxyallysine by LOX (Danio rerio)
Formation of hydroxyallysine by LOX (Gallus gallus)
Formation of hydroxyallysine by LOX (Mus musculus)
Formation of hydroxyallysine by LOX (Rattus norvegicus)
Formation of hydroxyallysine by LOX (Sus scrofa)
Formation of hydroxyallysine by LOX (Xenopus tropicalis)
Authored
Jupe, S  (2012-04-30)
Reviewed
Raleigh, S  (2012-10-08)
Ricard-Blum, S  (2012-11-19)
Kalamajski, S  (2012-10-08)
Created
Jupe, S  (2012-06-29)
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