Formation of hydroxyallysine by LOX

Stable Identifier
R-HSA-2395340
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Hydroxylysines residues can be converted to hydroxyallysines by lysyl oxidase. In this representative reaction a single hydroxylysine residue in each collagen chain is shown as converted to hydroxyallysine (Pinnell et al. 1968, Siegel 1979).

Literature References
PubMed ID Title Journal Year
41816 Lysyl oxidase

Siegel, RC

Int Rev Connect Tissue Res 1979
5246001 The cross-linking of collagen and elastin: enzymatic conversion of lysine in peptide linkage to alpha-aminoadipic-delta-semialdehyde (allysine) by an extract from bone

Pinnell, SR, Martin, GR

Proc Natl Acad Sci U S A 1968
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein-lysine 6-oxidase activity of Lysyl oxidases:Cu2+ [extracellular region]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed