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TGFB1(30-278) [extracellular region]
Stable Identifier
R-HSA-2395367
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
TGFB1, LAP1, Transforming Growth Factor beta 1 LAP
Icon
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Elastic fibre formation (Homo sapiens)
Molecules associated with elastic fibres (Homo sapiens)
LTBP1, LTBP3 bind TGF-Beta (Homo sapiens)
LTBP1, LTBP3:TGF betas:LAPs [extracellular region] (Homo sapiens)
TGF betas:LAPs [extracellular region] (Homo sapiens)
TGF-beta-1:LAP1 [extracellular region] (Homo sapiens)
TGFB1(30-278) [extracellular region] (Homo sapiens)
TGF betas:LAPs [extracellular region] (Homo sapiens)
TGF-beta-1:LAP1 [extracellular region] (Homo sapiens)
TGFB1(30-278) [extracellular region] (Homo sapiens)
LTBP4 binds TGF-Beta-1 (Homo sapiens)
LTBP4:TGF-beta-1:LAP1 [extracellular region] (Homo sapiens)
TGF-beta-1:LAP1 [extracellular region] (Homo sapiens)
TGFB1(30-278) [extracellular region] (Homo sapiens)
TGF-beta-1:LAP1 [extracellular region] (Homo sapiens)
TGFB1(30-278) [extracellular region] (Homo sapiens)
Latent TGF-beta-1 binds integrins (Homo sapiens)
TGF-beta-1:LAP1 [extracellular region] (Homo sapiens)
TGFB1(30-278) [extracellular region] (Homo sapiens)
TGF-beta-1:LAP1:LAP1-binding integrins [plasma membrane] (Homo sapiens)
TGF-beta-1:LAP1 [extracellular region] (Homo sapiens)
TGFB1(30-278) [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of STAT3-upregulated extracellular proteins (Homo sapiens)
STAT3-upregulated extracellular proteins [extracellular region] (Homo sapiens)
TGFB1(30-278) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01137 TGFB1
Gene Names
TGFB1, TGFB
Chain
signal peptide:1-29, chain:30-278, chain:279-390
Reference Genes
BioGPS Gene:7040 TGFB1
COSMIC (genes):TGFB1 TGFB1
CTD Gene:7040 TGFB1
dbSNP Gene:7040 TGFB1
ENSEMBL:ENSG00000105329 TGFB1
HGNC:11766 TGFB1
KEGG Gene (Homo sapiens):7040 TGFB1
Monarch:7040 TGFB1
NCBI Gene:7040 TGFB1
OMIM:190180 TGFB1
UCSC:P01137 TGFB1
Reference Transcript
RefSeq:NM_000660.6 TGFB1
Other Identifiers
0000360092
11716385_at
11723396_at
1634_s_at
16872551
1830_s_at
203084_at
203085_s_at
219766_at
361
3863028
3863029
3863030
3863032
3863033
3863035
3863036
3863037
3863038
3863039
3863040
3863047
3863048
41445_at
7040
73543
76345_r_at
8037005
A_23_P218476
A_24_P96171
CAB000361
CAB073543
CCDS33031
ENSG00000105329
ENSP00000221930
ENST00000221930
ENST00000221930.5
EntrezGene:7040
EntrezGene:TGFB1
g10863872_3p_at
g12652748_3p_a_at
g13385567_3p_at
GE59644
GO:0000003
GO:0000122
GO:0000165
GO:0000278
GO:0001570
GO:0001657
GO:0001666
GO:0001763
GO:0001775
GO:0001837
GO:0001843
GO:0001933
GO:0001934
GO:0002028
GO:0002062
GO:0002244
GO:0002248
GO:0002376
GO:0002460
GO:0002513
GO:0002576
GO:0003013
GO:0003179
GO:0003180
GO:0003674
GO:0003823
GO:0005114
GO:0005125
GO:0005160
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005794
GO:0005796
GO:0005886
GO:0005902
GO:0005975
GO:0006259
GO:0006464
GO:0006468
GO:0006611
GO:0006629
GO:0006754
GO:0006796
GO:0006810
GO:0006874
GO:0006913
GO:0006950
GO:0006954
GO:0007010
GO:0007049
GO:0007050
GO:0007093
GO:0007155
GO:0007165
GO:0007173
GO:0007179
GO:0007182
GO:0007183
GO:0007219
GO:0007406
GO:0007435
GO:0007492
GO:0007507
GO:0007565
GO:0007568
GO:0008083
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008285
GO:0008354
GO:0009056
GO:0009058
GO:0009314
GO:0009611
GO:0009749
GO:0009790
GO:0009817
GO:0009986
GO:0010033
GO:0010468
GO:0010575
GO:0010628
GO:0010629
GO:0010716
GO:0010718
GO:0010742
GO:0010763
GO:0010800
GO:0010862
GO:0010936
GO:0014003
GO:0014008
GO:0014070
GO:0016049
GO:0016192
GO:0016202
GO:0016477
GO:0017015
GO:0019049
GO:0019221
GO:0019899
GO:0021915
GO:0022408
GO:0022607
GO:0030141
GO:0030154
GO:0030198
GO:0030214
GO:0030217
GO:0030234
GO:0030279
GO:0030308
GO:0030316
GO:0030334
GO:0030335
GO:0030424
GO:0030501
GO:0030512
GO:0030879
GO:0031012
GO:0031065
GO:0031093
GO:0031100
GO:0031293
GO:0031334
GO:0031410
GO:0031536
GO:0031663
GO:0032270
GO:0032355
GO:0032570
GO:0032667
GO:0032700
GO:0032740
GO:0032801
GO:0032930
GO:0032943
GO:0032967
GO:0033138
GO:0033280
GO:0034330
GO:0034616
GO:0034641
GO:0034713
GO:0034714
GO:0035066
GO:0035307
GO:0035902
GO:0040007
GO:0040011
GO:0042060
GO:0042110
GO:0042127
GO:0042130
GO:0042306
GO:0042307
GO:0042482
GO:0042493
GO:0042552
GO:0042592
GO:0042802
GO:0042803
GO:0042981
GO:0043011
GO:0043025
GO:0043029
GO:0043065
GO:0043117
GO:0043226
GO:0043406
GO:0043408
GO:0043491
GO:0043536
GO:0043537
GO:0043539
GO:0043552
GO:0043932
GO:0044281
GO:0044403
GO:0045066
GO:0045216
GO:0045589
GO:0045591
GO:0045596
GO:0045599
GO:0045662
GO:0045786
GO:0045892
GO:0045893
GO:0045918
GO:0045930
GO:0045944
GO:0046716
GO:0046982
GO:0047485
GO:0048146
GO:0048298
GO:0048468
GO:0048535
GO:0048565
GO:0048642
GO:0048646
GO:0048839
GO:0048856
GO:0048870
GO:0050679
GO:0050680
GO:0050714
GO:0050731
GO:0050765
GO:0050777
GO:0050868
GO:0050900
GO:0050921
GO:0051092
GO:0051098
GO:0051101
GO:0051152
GO:0051276
GO:0051280
GO:0051301
GO:0051781
GO:0051897
GO:0055010
GO:0055085
GO:0060312
GO:0060325
GO:0060364
GO:0060389
GO:0060390
GO:0060391
GO:0060395
GO:0060744
GO:0060751
GO:0060762
GO:0060965
GO:0061035
GO:0061448
GO:0062023
GO:0065003
GO:0070168
GO:0070306
GO:0070374
GO:0070723
GO:0071158
GO:0071260
GO:0071363
GO:0071407
GO:0071479
GO:0071549
GO:0071560
GO:0071677
GO:0072562
GO:0085029
GO:0090190
GO:0097191
GO:0097421
GO:0140014
GO:1900126
GO:1900182
GO:1901203
GO:1901666
GO:1902074
GO:1902895
GO:1903077
GO:1903799
GO:1903800
GO:1903911
GO:1905313
GO:1990314
GO:1990402
GO:2000249
GO:2000679
GO:2000727
HGNC:11766
ILMN_1665766
ILMN_1806999
ILMN_2129668
IPR001111
IPR001839
IPR003939
IPR015615
IPR016319
IPR017948
IPR029034
M38449_s_at
MIM:131300
MIM:190180
MIM:219700
MIM:618213
NM_000660
NP_000651
PF00019
PF00688
PR01423
PR01424
SM00204
TC19001553.hg
TC19002485.hg
TGFB1
TGFB1-201
UPI000013C7E1
X05839_rna1_s_at
XM_011527242
XP_011525544
Participant Of
hasMember
STAT3-upregulated extracellular proteins [extracellular region]
hasComponent
TGF-beta-1:LAP1 [extracellular region]
Other forms of this molecule
TGFB1 [extracellular region]
TGFB1 [Golgi lumen]
TGFB1(30-390) [Golgi lumen]
TGFB1 [plasma membrane]
TGFB1(30-278) [platelet alpha granule lumen]
Inferred To
Homologues of TGFB1(30-278) [extracellular region] (Caenorhabditis elegans)
Homologues of TGFB1(30-278) [extracellular region] (Drosophila melanogaster)
TGFB1(30-278) [extracellular region] (Bos taurus)
TGFB1(30-278) [extracellular region] (Caenorhabditis elegans)
TGFB1(30-278) [extracellular region] (Canis familiaris)
TGFB1(30-278) [extracellular region] (Danio rerio)
TGFB1(30-278) [extracellular region] (Drosophila melanogaster)
TGFB1(30-278) [extracellular region] (Rattus norvegicus)
Tgfb1 [extracellular region] (Mus musculus)
Cross References
RefSeq
NP_000651.3
OpenTargets
ENSG00000105329
GeneCards
P01137
ZINC - Substances
TGFB1_HUMAN
ZINC target
P01137
PRO
P01137
ZINC - Predictions - Purchasable
TGFB1_HUMAN
Orphanet
15606
PDB
5FFO
,
1KLA
,
5VQP
,
3KFD
,
1KLC
,
1KLD
,
4KV5
Interactors (32)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P37173 TGFBR2
9
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 K128fs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 K128fs*35 [cytosol]
(R-HSA-3642166)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 [plasma membrane]
(R-HSA-170842)
0.811
6
UniProt:P05067 APP
20
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(672-711) [cytosol]
(R-HSA-877188)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.641
3
UniProt:Q14766-1 LTBP1
0.637
4
UniProt:Q14392 LRC32
0.564
2
UniProt:P11464 PSG1
1
PSG1 [extracellular region]
(R-HSA-8870766)
0.558
3
IntAct:EBI-10171584 80125
0.556
3
UniProt:P50222 MEOX2
0.556
3
UniProt:Q12841 FSTL1
3
FSTL1 [endoplasmic reticulum lumen]
(R-HSA-8956749)
p-FSTL1 [endoplasmic reticulum lumen]
(R-HSA-8957089)
FSTL1 [extracellular region]
(R-HSA-201832)
0.544
2
UniProt:P07996 THBS1
5
glc-fuc-THBS1 [endoplasmic reticulum lumen]
(R-HSA-5172997)
THBS1 [endoplasmic reticulum lumen]
(R-HSA-5173263)
O-fuc-THBS1 [endoplasmic reticulum lumen]
(R-HSA-5173278)
THBS1 [platelet alpha granule lumen]
(R-HSA-114701)
THBS1 [extracellular region]
(R-HSA-66518)
0.525
2
UniProt:P01137 TGFB1
6
TGFB1 [Golgi lumen]
(R-HSA-177108)
TGFB1 [extracellular region]
(R-HSA-170838)
TGFB1(30-390) [Golgi lumen]
(R-HSA-114705)
TGFB1 [plasma membrane]
(R-HSA-5146781)
TGFB1(30-278) [extracellular region]
(R-HSA-2395367)
TGFB1(30-278) [platelet alpha granule lumen]
(R-HSA-65936)
0.522
2
UniProt:O60711 LPXN
0.488
2
IntAct:EBI-12416678 RAPGEF3
0.488
2
UniProt:Q5TA81 LCE2C
1
LCE2C [cytosol]
(R-HSA-6814284)
0.488
2
UniProt:O14633 LCE2B
1
LCE2B [cytosol]
(R-HSA-6814295)
0.488
2
UniProt:Q8NEC5 CATSPER1
1
CATSPER1 [plasma membrane]
(R-HSA-2534335)
0.488
2
UniProt:P06756 ITGAV
3
ITGAV(31-1048) [specific granule membrane]
(R-HSA-6806145)
ITGAV(31-1048) [phagocytic vesicle]
(R-HSA-1236773)
ITGAV(31-1048) [plasma membrane]
(R-HSA-210013)
0.488
2
UniProt:Q9BYE3 LCE3D
1
LCE3D [cytosol]
(R-HSA-6814297)
0.488
2
UniProt:Q5T751 LCE1C
1
LCE1C [cytosol]
(R-HSA-6814267)
0.488
2
UniProt:Q5T752 LCE1D
1
LCE1D [cytosol]
(R-HSA-6814283)
0.488
2
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.488
2
UniProt:Q07627 KRTAP1-1
1
KRTAP1-1 [cytosol]
(R-HSA-6809855)
0.488
2
UniProt:Q5T7P2 LCE1A
1
LCE1A [cytosol]
(R-HSA-6814305)
0.488
2
UniProt:Q5TA76 LCE3A
1
LCE3A [cytosol]
(R-HSA-6814296)
0.488
2
UniProt:A0A0C3SFZ9 A0A0C3SFZ9
0.488
2
IntAct:EBI-11749135 KRTAP13
0.488
2
UniProt:Q6UY14-3 ADAMTSL4
0.488
2
UniProt:Q9BYQ6 KRTAP4-11
1
KRTAP4-11 [cytosol]
(R-HSA-6809960)
0.488
2
UniProt:Q5TA77 LCE3B
1
LCE3B [cytosol]
(R-HSA-6814269)
0.488
2
UniProt:Q12837 POU4F2
1
POU4F2 [nucleoplasm]
(R-HSA-6804414)
0.488
2
UniProt:P07237 P4HB
3
p-P4HB [endoplasmic reticulum lumen]
(R-HSA-8956902)
P4HB [endoplasmic reticulum lumen]
(R-HSA-174692)
HC53,56-P4HB [endoplasmic reticulum lumen]
(R-HSA-3341287)
0.488
2
UniProt:A8MQ03 CRTP1
0.488
2
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.488
2
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