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TGFB1(30-278) [extracellular region]
Stable Identifier
R-HSA-2395367
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
TGFB1, LAP1, Transforming Growth Factor beta 1 LAP
Icon
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Elastic fibre formation (Homo sapiens)
Molecules associated with elastic fibres (Homo sapiens)
LTBP1, LTBP3 bind TGF-Beta (Homo sapiens)
LTBP1, LTBP3:TGF betas:LAPs [extracellular region] (Homo sapiens)
TGF betas:LAPs [extracellular region] (Homo sapiens)
TGF-beta-1:LAP1 [extracellular region] (Homo sapiens)
TGFB1(30-278) [extracellular region] (Homo sapiens)
TGF betas:LAPs [extracellular region] (Homo sapiens)
TGF-beta-1:LAP1 [extracellular region] (Homo sapiens)
TGFB1(30-278) [extracellular region] (Homo sapiens)
LTBP4 binds TGF-Beta-1 (Homo sapiens)
LTBP4:TGF-beta-1:LAP1 [extracellular region] (Homo sapiens)
TGF-beta-1:LAP1 [extracellular region] (Homo sapiens)
TGFB1(30-278) [extracellular region] (Homo sapiens)
TGF-beta-1:LAP1 [extracellular region] (Homo sapiens)
TGFB1(30-278) [extracellular region] (Homo sapiens)
Latent TGF-beta-1 binds integrins (Homo sapiens)
TGF-beta-1:LAP1 [extracellular region] (Homo sapiens)
TGFB1(30-278) [extracellular region] (Homo sapiens)
TGF-beta-1:LAP1:LAP1-binding integrins [plasma membrane] (Homo sapiens)
TGF-beta-1:LAP1 [extracellular region] (Homo sapiens)
TGFB1(30-278) [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of STAT3-upregulated extracellular proteins (Homo sapiens)
STAT3-upregulated extracellular proteins [extracellular region] (Homo sapiens)
TGFB1(30-278) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01137 TGFB1
Gene Names
TGFB1, TGFB
Chain
signal peptide:1-29, chain:30-278, chain:279-390
Reference Genes
BioGPS Gene:7040 TGFB1
COSMIC (genes):TGFB1 TGFB1
CTD Gene:7040 TGFB1
dbSNP Gene:7040 TGFB1
ENSEMBL:ENSG00000105329 TGFB1
HGNC:11766 TGFB1
KEGG Gene (Homo sapiens):7040 TGFB1
Monarch:7040 TGFB1
NCBI Gene:7040 TGFB1
OMIM:190180 TGFB1
UCSC:P01137 TGFB1
Reference Transcript
RefSeq:NM_000660.6 TGFB1
Participates
as a member of
STAT3-upregulated extracellular proteins [extracellular region] (Homo sapiens)
as a component of
TGF-beta-1:LAP1 [extracellular region] (Homo sapiens)
Other forms of this molecule
TGFB1 [extracellular region]
TGFB1 [Golgi lumen]
TGFB1(30-390) [Golgi lumen]
TGFB1 [plasma membrane]
TGFB1(30-278) [platelet alpha granule lumen]
Inferred To
TGFB1 [extracellular region]
(Canis familiaris)
mav [extracellular region]
(Drosophila melanogaster)
Homologues of TGFB1(30-278) [extracellular region]
(Caenorhabditis elegans)
Homologues of TGFB1(30-278) [extracellular region]
(Drosophila melanogaster)
bmp3 [extracellular region]
(Xenopus tropicalis)
tgfb3 [extracellular region]
(Danio rerio)
dbl-1 [extracellular region]
(Caenorhabditis elegans)
Tgfb1 [extracellular region]
(Mus musculus)
Tgfb1 [extracellular region]
(Rattus norvegicus)
gbb [extracellular region]
(Drosophila melanogaster)
scw [extracellular region]
(Drosophila melanogaster)
unc-129 [extracellular region]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_000651.3
Target Pathogen
5b354852be737e166372e764
OpenTargets
ENSG00000105329
GeneCards
P01137
ZINC - Substances
TGFB1_HUMAN
HPA
ENSG00000105329-TGFB1
ZINC target
P01137
PRO
P01137
ZINC - Predictions - Purchasable
TGFB1_HUMAN
Orphanet
15606
PDB
4KV5
,
3KFD
,
6P7J
,
5FFO
,
1KLC
,
1KLD
,
1KLA
,
5VQP
,
6OM2
Interactors (32)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P37173 TGFBR2
9
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 K128fs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 K128fs*35 [cytosol]
(R-HSA-3642166)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 [plasma membrane]
(R-HSA-170842)
0.811
6
UniProt:Q14766-1 LTBP1
0.637
4
UniProt:P05067 APP
20
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.604
3
UniProt:Q14392 LRC32
0.564
2
UniProt:P11464 PSG1
1
PSG1 [extracellular region]
(R-HSA-8870766)
0.558
3
UniProt:O60711 LPXN
0.556
3
UniProt:Q5TA81 LCE2C
1
LCE2C [cytosol]
(R-HSA-6814284)
0.556
3
UniProt:O14633 LCE2B
1
LCE2B [cytosol]
(R-HSA-6814295)
0.556
3
IntAct:EBI-22335676 CCSB ORF ID
0.556
3
UniProt:Q8NEC5 CATSPER1
1
CATSPER1 [plasma membrane]
(R-HSA-2534335)
0.556
3
UniProt:Q9BYE3 LCE3D
1
LCE3D [cytosol]
(R-HSA-6814297)
0.556
3
UniProt:Q5T751 LCE1C
1
LCE1C [cytosol]
(R-HSA-6814267)
0.556
3
UniProt:Q5T752 LCE1D
1
LCE1D [cytosol]
(R-HSA-6814283)
0.556
3
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:Q07627 KRTAP1-1
1
KRTAP1-1 [cytosol]
(R-HSA-6809855)
0.556
3
UniProt:Q5T7P2 LCE1A
1
LCE1A [cytosol]
(R-HSA-6814305)
0.556
3
UniProt:Q5TA76 LCE3A
1
LCE3A [cytosol]
(R-HSA-6814296)
0.556
3
UniProt:A0A0C3SFZ9 A0A0C3SFZ9
0.556
3
UniProt:Q6UY14-3 ADAMTSL4
0.556
3
UniProt:Q9BYQ6 KRTAP4-11
1
KRTAP4-11 [cytosol]
(R-HSA-6809960)
0.556
3
UniProt:P50222 MEOX2
0.556
3
UniProt:Q5TA77 LCE3B
1
LCE3B [cytosol]
(R-HSA-6814269)
0.556
3
UniProt:Q12837 POU4F2
1
POU4F2 [nucleoplasm]
(R-HSA-6804414)
0.556
3
IntAct:EBI-22310722 CCSB ORF ID
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
IntAct:EBI-10171584 80125
0.556
3
UniProt:P07237 P4HB
3
p-P4HB [endoplasmic reticulum lumen]
(R-HSA-8956902)
P4HB [endoplasmic reticulum lumen]
(R-HSA-174692)
HC53,56-P4HB [endoplasmic reticulum lumen]
(R-HSA-3341287)
0.556
3
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.556
3
UniProt:Q12841 FSTL1
3
p-FSTL1 [endoplasmic reticulum lumen]
(R-HSA-8957089)
FSTL1 [extracellular region]
(R-HSA-201832)
FSTL1 [endoplasmic reticulum lumen]
(R-HSA-8956749)
0.544
2
UniProt:P07996 THBS1
5
glc-fuc-THBS1 [endoplasmic reticulum lumen]
(R-HSA-5172997)
THBS1 [endoplasmic reticulum lumen]
(R-HSA-5173263)
O-fuc-THBS1 [endoplasmic reticulum lumen]
(R-HSA-5173278)
THBS1 [platelet alpha granule lumen]
(R-HSA-114701)
THBS1 [extracellular region]
(R-HSA-66518)
0.525
2
UniProt:P01137 TGFB1
6
TGFB1 [Golgi lumen]
(R-HSA-177108)
TGFB1 [extracellular region]
(R-HSA-170838)
TGFB1(30-390) [Golgi lumen]
(R-HSA-114705)
TGFB1 [plasma membrane]
(R-HSA-5146781)
TGFB1(30-278) [extracellular region]
(R-HSA-2395367)
TGFB1(30-278) [platelet alpha granule lumen]
(R-HSA-65936)
0.522
2
UniProt:P06756 ITGAV
3
ITGAV(31-1048) [specific granule membrane]
(R-HSA-6806145)
ITGAV(31-1048) [phagocytic vesicle]
(R-HSA-1236773)
ITGAV(31-1048) [plasma membrane]
(R-HSA-210013)
0.488
2
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