Reactome | FDXR transfers electrons to FDX1,2 (FDX1L)

FDXR transfers electrons to FDX1,2 (FDX1L)

Stable Identifier

R-HSA-2395512

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

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FDXR transfers electrons to FDX1,2 (FDX1L)

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Two electrons are transferred from reduced ferredoxin reductase (FDXR, adrenodoxin reductase) to two ferredoxin-1 or ferredoxin-1L (FDX1, FDX1L) molecules, each of which binds one electron. Two protons are released during the reaction.

Literature References

PubMed ID	Title	Journal	Year
20547883	Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis Hobler, A, Webert, H, Pierik, AJ, Lill, R, Elsässer, HP, Bernhardt, R, Stehling, O, Sheftel, AD, Hannemann, F, Mühlenhoff, U	Proc. Natl. Acad. Sci. U.S.A.	2010
22101253	Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis Shi, Y, Kovtunovych, G, Crooks, DR, Ghosh, M, Rouault, TA	Biochim. Biophys. Acta	2012