Electron transport from NADPH to Ferredoxin

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R-HSA-2395516
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Pathway
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Homo sapiens
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NADPH, ferredoxin reductase (FDXR, Adrenodoxin reductase), and ferredoxins (FDX1, FDX1L) comprise a short electron transport chain that provides electrons for biosynthesis of iron-sulfur clusters and steroid hormones (Sheftel et al. 2010, Shi et al. 2012, reviewed in Grinberg et al. 2000, Lambeth et al. 1982).

Literature References
PubMed ID Title Journal Year
20547883 Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis

Sheftel, AD, Stehling, O, Pierik, AJ, Elsässer, HP, Mühlenhoff, U, Webert, H, Hobler, A, Hannemann, F, Bernhardt, R, Lill, R

Proc. Natl. Acad. Sci. U.S.A. 2010
10899784 Adrenodoxin: structure, stability, and electron transfer properties

Grinberg, AV, Hannemann, F, Schiffler, B, Müller, J, Heinemann, U, Bernhardt, R

Proteins 2000
7050653 Steroidogenic electron transport in adrenal cortex mitochondria

Lambeth, JD, Seybert, DW, Lancaster, JR, Salerno, JC, Kamin, H

Mol. Cell. Biochem. 1982
22101253 Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis

Shi, Y, Ghosh, M, Kovtunovych, G, Crooks, DR, Rouault, TA

Biochim. Biophys. Acta 2012
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