Latent TGF-beta-3 binds integrins

Stable Identifier
R-HSA-2396029
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The LAPs of TGF-beta1 and TGF-beta3 contain RGD sequences near the carboxyl termini that are bound by RGD-binding integrins. LAP3 binds alphaVBeta1, 3, 5 and 6 (Ludbrook et al. 2003) and 8 (Kitamura et al. 2011). Binding to integrins alphaVBeta6 and alphaVBeta8 leads to TGF-beta activation.

Literature References
PubMed ID Title Journal Year
12358597 The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3

Ludbrook, SB, Barry, ST, Delves, CJ, Horgan, CM

Biochem. J. 2003
21646718 Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin ?v?8-mediated activation of TGF-?

Kitamura, H, Cambier, S, Somanath, S, Barker, T, Minagawa, S, Markovics, J, Goodsell, A, Publicover, J, Reichardt, L, Jablons, D, Wolters, P, Hill, A, Marks, JD, Lou, J, Pittet, JF, Gauldie, J, Baron, JL, Nishimura, SL

J. Clin. Invest. 2011
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