HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer

Stable Identifier
R-HSA-2396337
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Perlecan binds multiple ECM components
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Perlecan (HSPG2) is a modular proteoglycan primarily located in the basement membranes of vascular tissues. It is involved in several developmental processes, both during embryogenesis and in human diseases such as cancer and diabetes (Iozzo et al. 1994). HSPG2 can self-aggregate into dimeric or multimeric forms (Yurchenco et al. 1987) and is involved in heterotypic interactions with numerous extracellular macromolecules (Whitelock et al. 2008, Perlecan entry in MatrixDB). HSPG2's GAG chains mediate interactions with fibroblast growth factor-2 (Vigny et al. 1988, Knox et al. 2002), and nidogens (Entactins, represented elsewhere). The core protein binds fibronectin (Isemura et al. 1987, Heremans et al. 1990, Vlodavsky et al. 1991), transthyretin (Smeland et al. 1997) and platelet-derived growth factor A and B homodimers (Göhring et al. 1998).

Literature References
PubMed ID Title Journal Year
11847221 Not all perlecans are created equal: interactions with fibroblast growth factor (FGF) 2 and FGF receptors

Knox, S, Merry, C, Stringer, S, Melrose, J, Whitelock, J

J. Biol. Chem. 2002
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created
Cite Us!