HSPG2 (perlecan) binds alpha-dystroglycan

Stable Identifier
R-HSA-2396395
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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HSPG2 (perlecan) binds alpha-dystroglycan
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HSPG2 (perlecan) is a modular proteoglycan primarily located in the basement membranes of vascularized tissues. It is involved in several developmental processes, both during embryogenesis and in human disease such as cancer and diabetes (Iozzo et al. 1994). Domain V of the core protein binds alpha-dystroglycan (Talts et al. 1999), which in vivo forms a membrane-associated heterodimer with beta-dystroglycan (Peng et al. 1998).
Literature References
PubMed ID Title Journal Year
10022829 Binding of the G domains of laminin alpha1 and alpha2 chains and perlecan to heparin, sulfatides, alpha-dystroglycan and several extracellular matrix proteins

Brancaccio, A, Timpl, R, Talts, JF, Göhring, W, Andac, Z

EMBO J. 1999
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Orthologous Events
HSPG2 (perlecan) binds alpha-dystroglycan (Caenorhabditis elegans)
HSPG2 (perlecan) binds alpha-dystroglycan (Drosophila melanogaster)
Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2012-07-09)
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