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Fibrillins bind BMPs

Stable Identifier
R-HSA-2396399
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Fibrillins can bind the prodomains of TGF-beta superfamily members bone morphogenic factor (BMP) 2, 4, 7, 10, and growth and differentiation factor (GDF) 5 (Sengle et al. 2008). Prodomain binding by ECM constituents may be a targeting mechanism for TGF family members (Sengle et al. 2011).

Literature References
PubMed ID Title Journal Year
18339631 Targeting of bone morphogenetic protein growth factor complexes to fibrillin J. Biol. Chem. 2008
Participants
Participant Of
Orthologous Events