Reactome: A Curated Pathway Database

Fibrillins bind BMPs

Stable Identifier
R-HSA-2396399
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Fibrillins can bind the prodomains of TGF-beta superfamily members bone morphogenic factor (BMP) 2, 4, 7, 10, and growth and differentiation factor (GDF) 5 (Sengle et al. 2008). Prodomain binding by ECM constituents may be a targeting mechanism for TGF family members (Sengle et al. 2011).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events